Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8061
Official Symbol:FOSL1
Other Aliases:FRA1|fra-1
See related:HGNC:13718|MIM:136515|HPRD:00643
Chromosome:11
Location:11q13
Gene Description:FOS-like antigen 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0135
ORGANISM:human
Entrez Gene ID:8061
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.58 :: 3.25 :: 2.44 :: 1.36 :: -3.02 :: -2.75 :: -3.68
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14283CBCerebellum0.00.0
14283CTXCerebral cortex0.00.0
14283HIPHippocampal region0.00.0
14283HPFHippocampal formation0.00.0
14283HYHypothalamus0.00.0
14283LSXLateral septal complex0.00.0
14283MBMidbrain0.00.0
14283MYMedulla0.00.0
14283OLFOlfactory bulb0.00.0
14283PPons0.00.0
14283PALPallidum0.00.0
14283RHPRetrohippocampal region0.00.0
14283sAMYStriatum-like amygdalar nuclei0.00.0
14283STRStriatum0.00.0
14283STRdStriatum dorsal region0.00.0
14283STRvStriatum ventral region0.00.0
14283THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8061GO:0003700TASFunctiontranscription factor activity
8061GO:0005634TASComponentnucleus
8061GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
8061GO:0006935TASProcesschemotaxis
8061GO:0006968TASProcesscellular defense response
8061GO:0008284TASProcesspositive regulation of cell proliferation
8061GO:0009615TASProcessresponse to virus
8061GO:0043565IEAFunctionsequence-specific DNA binding
8061GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8061FOSL1_HUMANP15407IPR011616bZIP_1bZIP transcription factor, bZIP_1
8061FOSL1_HUMANP15407IPR011700bZIP_2Basic leucine zipper
8061FOSL1_HUMANP15407IPR001630Leuzip_CREBcAMP response element binding (CREB) protein
8061FOSL1_HUMANP15407IPR000837Leuzip_FosFos transforming protein
8061FOSL1_HUMANP15407IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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