Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:814
Official Symbol:CAMK4
Other Aliases:CaMK-GR|MGC36771
See related:HGNC:1464|MIM:114080|HPRD:07169
Chromosome:5
Location:5q21.3
Gene Description:calcium/calmodulin-dependent protein kinase IV
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0348
ORGANISM:human
Entrez Gene ID:814
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.71
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12326CBCerebellum80.72333145141694.7615623474121
12326CTXCerebral cortex79.944576263427774.1850624084473
12326HIPHippocampal region20.610961437225332.9009189605713
12326HPFHippocampal formation36.413580894470238.944206237793
12326HYHypothalamus2.231149762868881.12154120206833
12326LSXLateral septal complex12.08529448509228.48086810112
12326MBMidbrain2.157510966062551.49940004944801
12326MYMedulla2.735516667366032.49577641487122
12326OLFOlfactory bulb49.880419731140142.3430814743042
12326PPons2.158993512392041.10780061781406
12326PALPallidum13.248897790908811.6665906906128
12326RHPRetrohippocampal region55.128196716308644.8606567382812
12326sAMYStriatum-like amygdalar nuclei16.994491577148411.6850304603577
12326STRStriatum96.563915252685596.0734710693359
12326STRdStriatum dorsal region100.0100.0
12326STRvStriatum ventral region93.521766662597793.0231323242188
12326THThalamus18.450024127960210.6980211734772
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
814GO:0000166IEAFunctionnucleotide binding
814GO:0004674IEAFunctionprotein serine/threonine kinase activity
814GO:0004685TASFunctioncalcium- and calmodulin-dependent protein kinase activity
814GO:0005509IEAFunctioncalcium ion binding
814GO:0005516IEAFunctioncalmodulin binding
814GO:0005524IEAFunctionATP binding
814GO:0005634IEAComponentnucleus
814GO:0006468TASProcessprotein amino acid phosphorylation
814GO:0007165TASProcesssignal transduction
814GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-84254NP_757344.1calcium/calmodulin-dependent protein kinase 1 alpha isoform bHPRD13000
NP_001735.110645NP_006540.3calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1HPRD06467
NP_001735.110645NP_006540.3calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1HPRD07169
NP_001735.123523NP_036427.1calcineurin binding protein 1BIND301689
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
814KCC4_HUMANQ16566IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
814KCC4_HUMANQ16566IPR002291Phosph_kin_gammaPhosphorylase kinase, gamma catalytic subunit
814KCC4_HUMANQ16566IPR000719Prot_kinaseProtein kinase
814KCC4_HUMANQ16566IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
814KCC4_HUMANQ16566IPR001245Tyr_pkinaseTyrosine protein kinase
814KCC4_HUMANQ16566IPR013695WAKWall-associated kinase

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