Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:815
Official Symbol:CAMK2A
Other Aliases:CAMKA|KIAA0968
See related:HGNC:1460|MIM:114078|HPRD:06532
Chromosome:5
Location:5q33.1
Gene Description:calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0115
ORGANISM:human
Entrez Gene ID:815
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12322
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0536
ORGANISM:human
Entrez Gene ID:815
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25400
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12322CBCerebellum26.103017807006886.8929100036621
12322CTXCerebral cortex100.0100.0
12322HIPHippocampal region100.0100.0
12322HPFHippocampal formation100.0100.0
12322HYHypothalamus100.0100.0
12322LSXLateral septal complex100.0100.0
12322MBMidbrain91.969463348388797.7789573669434
12322MYMedulla68.344984054565488.2446899414062
12322OLFOlfactory bulb100.0100.0
12322PPons74.082729339599693.3967742919922
12322PALPallidum95.884033203125100.0
12322RHPRetrohippocampal region100.0100.0
12322sAMYStriatum-like amygdalar nuclei100.0100.0
12322STRStriatum100.0100.0
12322STRdStriatum dorsal region100.0100.0
12322STRvStriatum ventral region100.0100.0
12322THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
815GO:0000166IEAFunctionnucleotide binding
815GO:0004674IEAFunctionprotein serine/threonine kinase activity
815GO:0005524IEAFunctionATP binding
815GO:0005954TASComponentcalcium- and calmodulin-dependent protein kinase complex
815GO:0006468IEAProcessprotein amino acid phosphorylation
815GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD00697
-3706NP_002211.11D-myo-inositol-trisphosphate 3-kinase AHPRD00941
-8831NP_006763.1synaptic Ras GTPase activating protein 1HPRD16018
-2902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
-23604NP_055141.2death-associated protein kinase 2HPRD09905
-94032NP_150284.1CaM-KII inhibitory proteinHPRD16377
NP_057065.294032-CaMKII inhibitory proteinHPRD06532
NP_057065.223604-Death associated protein kinase 2HPRD06532
NP_057065.22902-Glutamate receptor ionotropic, N-methyl D-aspartate 1HPRD06532
NP_057065.22904-N-methyl D-aspartate receptor subunit 2BHPRD06532
NP_057065.23706-Inositol-trisphosphate 3-kinase AHPRD06532
NP_057065.28851-Cyclin dependent kinase 5, regulatory subunit 1HPRD06532
NP_057065.21739-Synapse associated protein 97HPRD06532
NP_057065.257554NP_065845.1leucine rich repeat containing 7HPRD06532
NP_057065.257554NP_065845.1leucine rich repeat containing 7HPRD09930
NP_057065.285461NP_203752.1TPR domain, ankyrin-repeat and coiled-coil-containingHPRD06532
NP_057065.285461NP_203752.1TPR domain, ankyrin-repeat and coiled-coil-containingHPRD18146
NP_057065.2155871NP_057853.1Tat--
NP_057065.2155871NP_057853.1Tat--
NP_741960.157554NP_065845.1leucine rich repeat containing 7BIND258909
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
815IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
815IPR002291Phosph_kin_gammaPhosphorylase kinase, gamma catalytic subunit
815IPR000719Prot_kinaseProtein kinase
815IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
815IPR013695WAKWall-associated kinase
815KCC2A_HUMANQ9UQM7IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
815KCC2A_HUMANQ9UQM7IPR002291Phosph_kin_gammaPhosphorylase kinase, gamma catalytic subunit
815KCC2A_HUMANQ9UQM7IPR000719Prot_kinaseProtein kinase
815KCC2A_HUMANQ9UQM7IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
815KCC2A_HUMANQ9UQM7IPR013695WAKWall-associated kinase

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.