Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:81542
Official Symbol:TXNDC
Other Aliases:DKFZP564E1962|TMX|TXNDC1
See related:HGNC:15487|HPRD:15590
Chromosome:14
Location:14q22.1
Gene Description:thioredoxin domain containing
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0262
ORGANISM:human
Entrez Gene ID:81542
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
72736CBCerebellum6.406954288482676.45984888076782
72736CTXCerebral cortex0.7146264314651490.59021133184433
72736HIPHippocampal region5.56245660781865.1567964553833
72736HPFHippocampal formation4.24468708038333.75092959403992
72736HYHypothalamus7.21142005920415.77482032775879
72736LSXLateral septal complex0.6103936433792110.490728765726089
72736MBMidbrain2.35004973411562.36427092552185
72736MYMedulla4.917923927307134.77554416656494
72736OLFOlfactory bulb4.069604873657233.97257328033447
72736PPons3.350589036941533.38390278816223
72736PALPallidum2.723942995071412.31134510040283
72736RHPRetrohippocampal region1.91623806953431.77291083335876
72736sAMYStriatum-like amygdalar nuclei2.892963171005252.1390643119812
72736STRStriatum0.7977496981620790.706123530864716
72736STRdStriatum dorsal region0.619777441024780.655497014522552
72736STRvStriatum ventral region0.3574356436729430.251691073179245
72736THThalamus2.081611633300781.77520036697388
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
81542GO:0005624IDAComponentmembrane fraction
81542GO:0005789IDAComponentendoplasmic reticulum membrane
81542GO:0006118IEAProcesselectron transport
81542GO:0006260NASProcessDNA replication
81542GO:0006888TASProcessER to Golgi vesicle-mediated transport
81542GO:0006916IDAProcessanti-apoptosis
81542GO:0006950NASProcessresponse to stress
81542GO:0007165NASProcesssignal transduction
81542GO:0008283NASProcesscell proliferation
81542GO:0016020IEAComponentmembrane
81542GO:0016021IEAComponentintegral to membrane
81542GO:0030508IDAFunctionthiol-disulfide exchange intermediate activity
81542GO:0030612NASFunctionarsenate reductase (thioredoxin) activity
81542GO:0045321NASProcessimmune cell activation
81542GO:0045893NASProcesspositive regulation of transcription, DNA-dependent
81542GO:0045927NASProcesspositive regulation of growth
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
81542TXND1_HUMANQ9H3N1IPR006662ThioredThioredoxin-related
81542TXND1_HUMANQ9H3N1IPR013766Thioredoxin_domThioredoxin domain
81542TXND1_HUMANQ9H3N1IPR006663Thioredox_dom2Thioredoxin domain 2

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