Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:824
Official Symbol:CAPN2
Other Aliases:CANPL2|CANPml|mCANP
See related:HGNC:1479|MIM:114230|HPRD:00254
Chromosome:1
Location:1q41-q42
Gene Description:calpain 2, (m/II) large subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0565
ORGANISM:human
Entrez Gene ID:824
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29154
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12334CBCerebellum19.924451828002943.1625785827637
12334CTXCerebral cortex18.709184646606415.8562002182007
12334HIPHippocampal region9.7574160099029510.5669257640839
12334HPFHippocampal formation10.63955497741710.1643912792206
12334HYHypothalamus7.976603031158457.1148886680603
12334LSXLateral septal complex3.822538599371913.47541785985231
12334MBMidbrain15.97615861892717.8880262374878
12334MYMedulla32.46426200866747.2783279418945
12334OLFOlfactory bulb18.430470466613817.4785284996033
12334PPons26.388715744018634.3232583999634
12334PALPallidum15.55919647216816.934778213501
12334RHPRetrohippocampal region12.43773412704479.94048738479614
12334sAMYStriatum-like amygdalar nuclei5.776789426803595.03508591651917
12334STRStriatum5.112967252731324.9426486492157
12334STRdStriatum dorsal region4.494548678398134.70303654670715
12334STRvStriatum ventral region7.276066780090336.0544900894165
12334THThalamus19.31888675689718.2575373649597
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
824GO:0004198IEAFunctioncalpain activity
824GO:0005509IEAFunctioncalcium ion binding
824GO:0005622IEAComponentintracellular
824GO:0006508IEAProcessproteolysis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3827NP_000884.1kininogen 1HPRD01970
-2620NP_005247.1growth arrest-specific 2HPRD04158
-7145NP_072174.2tensinHPRD02512
-84290NP_115706.1calpain small subunit 2HPRD16682
NP_001739.13827-KininogenHPRD00254
NP_001739.17145-Tensin 1HPRD00254
NP_001739.12620-Growth arrest specific Protein 2HPRD00254
NP_001739.1826NP_001740.1calpain, small subunit 1HPRD00254
NP_001739.1826NP_001740.1calpain, small subunit 1HPRD00240
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
824CAN2_HUMANP17655IPR013567EF_hand_assoc_2EF hand associated, type-2
824CAN2_HUMANP17655IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
824CAN2_HUMANP17655IPR013684Miro-likeMiro-like
824CAN2_HUMANP17655IPR013623NADPH_OxNADPH oxidase Respiratory burst
824CAN2_HUMANP17655IPR001300Peptidase_C2Peptidase C2, calpain
824CAN2_HUMANP17655IPR000169Pept_cys_ASPeptidase, cysteine peptidase active site

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