Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:825
Official Symbol:CAPN3
Other Aliases:CANP3|CANPL3|LGMD2|LGMD2A|MGC10767|MGC11121|MGC14344|MGC4403|nCL-1|p94
See related:HGNC:1480|MIM:114240|HPRD:00255
Chromosome:15
Location:15q15.1-q21.1
Gene Description:calpain 3, (p94)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0844
ORGANISM:human
Entrez Gene ID:825
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12335CBCerebellum23.539165496826236.7517356872559
12335CTXCerebral cortex48.249477386474638.4703941345215
12335HIPHippocampal region20.701271057128922.3409042358398
12335HPFHippocampal formation23.212087631225622.2821464538574
12335HYHypothalamus7.563221454620366.10179996490479
12335LSXLateral septal complex3.059801578521732.1133599281311
12335MBMidbrain20.428569793701219.3518600463867
12335MYMedulla34.142353057861341.3087005615234
12335OLFOlfactory bulb46.361396789550840.6263313293457
12335PPons20.175790786743222.0724391937256
12335PALPallidum11.41000175476079.63096618652344
12335RHPRetrohippocampal region28.307834625244122.9415493011475
12335sAMYStriatum-like amygdalar nuclei10.02224159240726.49974584579468
12335STRStriatum10.25395202636727.39931201934814
12335STRdStriatum dorsal region9.106687545776376.76004934310913
12335STRvStriatum ventral region18.037273406982412.2293796539307
12335THThalamus31.604955673217826.4120979309082
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
825GO:0004198IEAFunctioncalpain activity
825GO:0004198TASFunctioncalpain activity
825GO:0004871TASFunctionsignal transducer activity
825GO:0005509IEAFunctioncalcium ion binding
825GO:0005622IEAComponentintracellular
825GO:0005622TASComponentintracellular
825GO:0006508IEAProcessproteolysis
825GO:0006508TASProcessproteolysis
825GO:0007517TASProcessmuscle development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000061.12318NP_001449.1gamma filaminHPRD00255
NP_000061.12318NP_001449.1gamma filaminHPRD00018
NP_000061.16709NP_003118.1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD00255
NP_000061.16709NP_003118.1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD01684
NP_000061.17273NP_003310.2titin isoform N2-BHPRD01787
NP_000061.17273NP_003310.2titin isoform N2-BHPRD00255
NP_000061.110971NP_006817.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptideHPRD00255
NP_000061.17532NP_036611.2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideHPRD00255
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
825IPR013567EF_hand_assoc_2EF hand associated, type-2
825IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
825IPR013684Miro-likeMiro-like
825IPR013623NADPH_OxNADPH oxidase Respiratory burst
825IPR001300Peptidase_C2Peptidase C2, calpain
825IPR000169Pept_cys_ASPeptidase, cysteine peptidase active site
825CAN3_HUMANP20807IPR013567EF_hand_assoc_2EF hand associated, type-2
825CAN3_HUMANP20807IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
825CAN3_HUMANP20807IPR013684Miro-likeMiro-like
825CAN3_HUMANP20807IPR013623NADPH_OxNADPH oxidase Respiratory burst
825CAN3_HUMANP20807IPR001300Peptidase_C2Peptidase C2, calpain
825CAN3_HUMANP20807IPR000169Pept_cys_ASPeptidase, cysteine peptidase active site

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