Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:832
Official Symbol:CAPZB
Other Aliases:CAPB|CAPPB|CAPZ|MGC104401|MGC129749|MGC129750
See related:HGNC:1491|MIM:601572|HPRD:11872
Chromosome:1
Location:1p36.1
Gene Description:capping protein (actin filament) muscle Z-line, beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0013
ORGANISM:human
Entrez Gene ID:832
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:12345
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0121
ORGANISM:human
Entrez Gene ID:832
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.41 :: 1.69 :: 0.66 :: 1.13 :: -0.63 :: -1.00 :: -0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12345CBCerebellum43.52605056762793.9678649902344
12345CTXCerebral cortex100.0100.0
12345HIPHippocampal region100.0100.0
12345HPFHippocampal formation100.0100.0
12345HYHypothalamus93.1109466552734100.0
12345LSXLateral septal complex100.0100.0
12345MBMidbrain92.7227783203125100.0
12345MYMedulla92.2099151611328100.0
12345OLFOlfactory bulb100.0100.0
12345PPons85.9265747070312100.0
12345PALPallidum93.265380859375100.0
12345RHPRetrohippocampal region100.0100.0
12345sAMYStriatum-like amygdalar nuclei97.3793258666992100.0
12345STRStriatum100.099.9881744384766
12345STRdStriatum dorsal region100.096.7644882202148
12345STRvStriatum ventral region100.0100.0
12345THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
832GO:0003779IEAFunctionactin binding
832GO:0003779TASFunctionactin binding
832GO:0006928TASProcesscell motility
832GO:0008290IEAComponentF-actin capping protein complex
832GO:0008290TASComponentF-actin capping protein complex
832GO:0030036IEAProcessactin cytoskeleton organization and biogenesis
832GO:0051016IEAProcessbarbed-end actin filament capping
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004921.14215NP_002392.1MAP/ERK kinase kinase 3HPRD11872
NP_004921.111035NP_006862.2receptor-interacting serine-threonine kinase 3HPRD11872
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
832IPR001698Factin_cap_betaF-actin capping protein, beta subunit

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