Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:835
Official Symbol:CASP2
Other Aliases:CASP-2|ICH-1L|ICH-1L/1S|ICH1|NEDD2
See related:HGNC:1503|MIM:600639|HPRD:02800
Chromosome:7
Location:7q34-q35
Gene Description:caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0553
ORGANISM:human
Entrez Gene ID:835
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64314
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12366CBCerebellum0.920871973037721.3701856136322
12366CTXCerebral cortex0.5378824472427370.82097464799881
12366HIPHippocampal region0.6935123801231380.998781859874725
12366HPFHippocampal formation0.5522604584693910.759290516376495
12366HYHypothalamus0.2570844590663910.268681406974792
12366LSXLateral septal complex0.9310916662216191.0550149679184
12366MBMidbrain0.6046424508094791.15335810184479
12366MYMedulla0.7557790875434881.16976392269135
12366OLFOlfactory bulb4.387106418609625.13062334060669
12366PPons1.21383070945741.76726162433624
12366PALPallidum0.1700714379549030.312230050563812
12366RHPRetrohippocampal region0.3388683497905730.464605987071991
12366sAMYStriatum-like amygdalar nuclei0.2774024307727810.305579155683517
12366STRStriatum0.3382130861282350.384186446666718
12366STRdStriatum dorsal region0.1641161888837810.185024261474609
12366STRvStriatum ventral region0.5123417973518370.496989369392395
12366THThalamus0.3786725401878361.32449078559875
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
835GO:0005515IEAFunctionprotein binding
835GO:0005622IEAComponentintracellular
835GO:0006508IEAProcessproteolysis
835GO:0006508TASProcessproteolysis
835GO:0006916NASProcessanti-apoptosis
835GO:0008234IEAFunctioncysteine-type peptidase activity
835GO:0008372NDComponentcellular component unknown
835GO:0008632TASProcessapoptotic program
835GO:0019899ISSFunctionenzyme binding
835GO:0030693NASFunctioncaspase activity
835GO:0030693TASFunctioncaspase activity
835GO:0042981IEAProcessregulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-896NP_001751.1cyclin D3HPRD00452
-8738NP_003796.1CASP2 and RIPK1 domain containing adaptor with death domainHPRD04584
-8996NP_003937.1nucleolar protein 3HPRD05572
-1639NP_004073.2dynactin 1 isoform 1HPRD07206
-2802NP_005886.2Golgi autoantigen, golgin subfamily a, 3HPRD03990
-10392NP_006083.1caspase recruitment domain family, member 4HPRD05815
-23581NP_036246.1caspase 14 precursorHPRD05788
-22861NP_127497.1death effector filament-forming Ced-4-like apoptosis protein isoform 1HPRD07364
NP_116764.2--DEFCAPHPRD02800
NP_116764.2--PACAPHPRD02800
NP_116764.2--PIDDHPRD02800
NP_116764.2---BIND133345
NP_116764.28738-Death adaptor molecule RAIDDHPRD02800
NP_116764.28738-RAIDDHPRD02800
NP_116764.28996-Nucleolar protein 3HPRD02800
NP_116764.223581-Caspase 14HPRD02800
NP_116764.210392-NOD1HPRD02800
NP_116764.22802-Golgin 160HPRD02800
NP_116764.222861-NACHT, LRR and PYD containing protein 1HPRD02800
NP_116764.21639-Dynactin 1HPRD02800
NP_116764.2896-Cyclin D3HPRD02800
NP_116764.23838-Karyopherin alpha 2HPRD02800
NP_116764.28738NP_003796.1CASP2 and RIPK1 domain containing adaptor with death domainBIND130909
NP_116764.21832NP_004406.1desmoplakinHPRD02800
NP_116764.21832NP_004406.1desmoplakinHPRD00513
NP_116764.2843NP_116759.2caspase 10 isoform d preproproteinHPRD03458
NP_116764.2843NP_116759.2caspase 10 isoform d preproproteinHPRD02800
NP_116764.2840NP_203124.1caspase 7 isoform deltaHPRD03457
NP_116764.2840NP_203124.1caspase 7 isoform deltaHPRD02800
NP_116764.255367NP_665893.1leucine rich repeat and death domain containing protein isoform 1HPRD02800
NP_116764.255367NP_665893.1leucine rich repeat and death domain containing protein isoform 1HPRD11284
P425755925NP_000312.1retinoblastoma 1BIND295187
P425753064NP_002102.2huntingtinBIND151448
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
835CASP2_HUMANP42575IPR001315CARDCaspase Recruitment
835CASP2_HUMANP42575IPR001309ICE_p20Caspase, p20 subunit
835CASP2_HUMANP42575IPR011600Pept_C14_catPeptidase C14, caspase catalytic
835CASP2_HUMANP42575IPR002138Pept_C14_p10Peptidase C14, caspase non-catalytic subunit p10
835CASP2_HUMANP42575IPR002398Pept_C14_p45Peptidase C14, caspase precursor p45

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