Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:836
Official Symbol:CASP3
Other Aliases:CPP32|CPP32B|SCA-1
See related:HGNC:1504|MIM:600636|HPRD:02799
Chromosome:4
Location:4q34
Gene Description:caspase 3, apoptosis-related cysteine peptidase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0045
ORGANISM:human
Entrez Gene ID:836
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10534122
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:Jurkat cells / T lymphocytes
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12367CBCerebellum40.95808029174852.7098274230957
12367CTXCerebral cortex100.092.3497543334961
12367HIPHippocampal region56.239440917968877.8284530639648
12367HPFHippocampal formation65.011215209960975.7452697753906
12367HYHypothalamus47.589466094970741.0555992126465
12367LSXLateral septal complex53.892158508300839.7782669067383
12367MBMidbrain30.870965957641628.074649810791
12367MYMedulla47.137439727783247.7542190551758
12367OLFOlfactory bulb100.0100.0
12367PPons31.879219055175830.4237880706787
12367PALPallidum43.435428619384838.7196388244629
12367RHPRetrohippocampal region86.272796630859477.3031311035156
12367sAMYStriatum-like amygdalar nuclei77.208686828613356.8462448120117
12367STRStriatum79.648384094238361.9828033447266
12367STRdStriatum dorsal region78.939765930175862.1336555480957
12367STRvStriatum ventral region94.084091186523471.5172958374023
12367THThalamus42.571495056152335.2370414733887
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
836GO:0005515IPIFunctionprotein binding
836GO:0006508IDAProcessproteolysis
836GO:0006508IEAProcessproteolysis
836GO:0006915IEAProcessapoptosis
836GO:0006917TASProcessinduction of apoptosis
836GO:0008234IEAFunctioncysteine-type peptidase activity
836GO:0030693IEAFunctioncaspase activity
836GO:0030693TASFunctioncaspase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8837AAC51623.1Homo sapiens FLICE-like inhibitory protein short form mRNA, complete cds.BIND195719
-1975NP_001408.1eukaryotic translation initiation factor 4BHPRD04892
-8837NP_003870.3CASP8 and FADD-like apoptosis regulatorHPRD04671
-1639NP_004073.2dynactin 1 isoform 1HPRD07206
-1676NP_004392.1DNA fragmentation factor, 45kDa, alpha polypeptide isoform 1HPRD03531
-6721NP_004590.2sterol regulatory element-binding transcription factor 2HPRD02726
-1630NP_005206.1deleted in colorectal carcinomaHPRD00391
-3059NP_005326.1hematopoietic cell-specific Lyn substrate 1HPRD03199
-4001NP_005564.1lamin B1HPRD01036
-7185NP_005649.1TNF receptor-associated factor 1HPRD03418
-10846NP_006652.1phosphodiesterase 10AHPRD17828
-6731NP_008878.1signal recognition particle 72kDaHPRD03671
-8301NP_009097.1phosphatidylinositol-binding clathrin assembly proteinHPRD04320
-30818NP_038462.1Kv channel interacting protein 3 isoform 1HPRD05232
-64689NP_114105.1Golgi reassembly stacking protein 1HPRD06038
-84951NP_116254.3C-terminal tensin-likeBIND300804
-9191NP_127491.1death effector domain-containing proteinHPRD06022
-985NP_277073.1cell division cycle 2-like 2 isoform 5HPRD00308
-79444NP_647478.1livin inhibitor of apoptosis isoform alphaHPRD05761
-7187NP_663777.1TNF receptor-associated factor 3 isoform 1HPRD03539
NP_004337.2--DSEB/RF-C140HPRD02799
NP_004337.2--ASFV IAPHPRD02799
NP_004337.2--PDE10A2HPRD02799
NP_004337.2--PDE5A1HPRD02799
NP_004337.2--K8/K18HPRD02799
NP_004337.2---BIND295481
NP_004337.26721-SREBP2HPRD02799
NP_004337.28837-c-FLIPHPRD02799
NP_004337.26731-SRP72HPRD02799
NP_004337.28301-CALMHPRD02799
NP_004337.279444-Baculoviral IAP repeat containing protein 7HPRD02799
NP_004337.27185-TRAF1HPRD02799
NP_004337.21630-DCCHPRD02799
NP_004337.27187-TRAF3HPRD02799
NP_004337.21975-Eukaryotic translation initiation factor 4BHPRD02799
NP_004337.230818-CalsenilinHPRD02799
NP_004337.21639-Dynactin 1HPRD02799
NP_004337.23059-Hematopoietic cell specific LYN substrate 1HPRD02799
NP_004337.21676-DNA fragmentation factor 45HPRD02799
NP_004337.264689-Golgi reassembly stacking protein 1HPRD02799
NP_004337.24001-Lamin B1HPRD02799
NP_004337.29191-DEDDHPRD02799
NP_004337.24287AAB33571.1MJD1=MJD1 protein {CAG repeats} [human, brain, mRNA, 1776 nt]BIND151544
NP_004337.25530NP_000935.1protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)HPRD00234
NP_004337.25530NP_000935.1protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)HPRD02799
NP_004337.2842NP_001220.2caspase 9 isoform alpha preproproteinHPRD03756
NP_004337.21499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaHPRD02799
NP_004337.21499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaHPRD00286
NP_004337.21822NP_001931.1atrophin-1BIND151505
NP_004337.23064NP_002102.2huntingtinBIND151490
NP_004337.23329NP_002147.2chaperoninHPRD02799
NP_004337.23329NP_002147.2chaperoninHPRD00318
NP_004337.23336NP_002148.1heat shock 10kDa protein 1 (chaperonin 10)HPRD02535
NP_004337.23336NP_002148.1heat shock 10kDa protein 1 (chaperonin 10)HPRD02799
NP_004337.24756NP_002490.1neogenin homolog 1BIND151651
NP_004337.28505NP_003622.1poly (ADP-ribose) glycohydrolaseHPRD04611
NP_004337.28505NP_003622.1poly (ADP-ribose) glycohydrolaseHPRD02799
NP_004337.28615NP_003706.1vesicle docking protein p115HPRD09135
NP_004337.2836NP_004337.2caspase 3 preproproteinHPRD02799
NP_004337.27052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD01825
NP_004337.27052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD02799
NP_004337.24719NP_004997.4NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa precursorBIND144671
NP_004337.24780NP_006155.2nuclear factor (erythroid-derived 2)-like 2HPRD02799
NP_004337.24780NP_006155.2nuclear factor (erythroid-derived 2)-like 2HPRD02732
NP_004337.29748NP_055535.2serine/threonine kinase 2HPRD11585
NP_004337.257448NP_057336.1baculoviral IAP repeat-containing 6BIND180575
NP_004337.251177NP_057358.2OC120BIND215336
NP_004337.254938NP_060297.1seryl-tRNA synthetase 2HPRD15295
NP_004337.2155807NP_057852.2Vpr--
NP_004337.2155871NP_057853.1Tat--
NP_004337.2155945NP_057855.1Vpu--
NP_116786.15925NP_000312.1retinoblastoma 1BIND295188
NP_116786.18837NP_003870.3CASP8 and FADD-like apoptosis regulatorBIND195916
NP_116786.15663NP_015557.1presenilin 1 isoform I-463BIND57546
NP_116786.157448NP_057336.1baculoviral IAP repeat-containing 6BIND180577
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
836CASP3_HUMANP42574IPR001309ICE_p20Caspase, p20 subunit
836CASP3_HUMANP42574IPR011600Pept_C14_catPeptidase C14, caspase catalytic
836CASP3_HUMANP42574IPR002138Pept_C14_p10Peptidase C14, caspase non-catalytic subunit p10
836CASP3_HUMANP42574IPR002398Pept_C14_p45Peptidase C14, caspase precursor p45

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