Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:83667
Official Symbol:SESN2
Other Aliases:DKFZp761M0212|DKFZp761M02121|HI95|SES2|SEST2
See related:HGNC:20746|MIM:607767|HPRD:06378
Chromosome:1
Location:1p35.3
Gene Description:sestrin 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0298
ORGANISM:human
Entrez Gene ID:83667
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.56
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
230784CBCerebellum0.7693424820899961.17294883728027
230784CTXCerebral cortex4.294865608215333.48051762580872
230784HIPHippocampal region1.923789143562322.40254235267639
230784HPFHippocampal formation1.533535003662111.71826481819153
230784HYHypothalamus0.1787829101085660.291376054286957
230784LSXLateral septal complex0.05810828879475590.0
230784MBMidbrain0.7129111289978031.21349990367889
230784MYMedulla0.6995249390602111.37693250179291
230784OLFOlfactory bulb1.596881270408631.95885694026947
230784PPons0.406543314456940.688324153423309
230784PALPallidum0.128059998154640.179606005549431
230784RHPRetrohippocampal region0.6945903897285460.58193838596344
230784sAMYStriatum-like amygdalar nuclei0.2380315065383910.716511726379395
230784STRStriatum0.2567041814327240.451495915651321
230784STRdStriatum dorsal region0.2846249341964720.375762850046158
230784STRvStriatum ventral region0.2212588489055630.676565885543823
230784THThalamus1.167811393737792.39910244941711
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
83667GO:0005634IEAComponentnucleus
83667GO:0007050IEAProcesscell cycle arrest
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_113647.1---BIND130613
NP_113647.1---BIND130612
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
83667SESN2_HUMANP58004IPR006730PA26PA26 p53-induced protein (sestrin)

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