Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:837
Official Symbol:CASP4
Other Aliases:ICE(rel)II|ICEREL-II|ICH-2|Mih1/TX|TX
See related:HGNC:1505|MIM:602664|HPRD:04047
Chromosome:11
Location:11q22.2-q22.3
Gene Description:caspase 4, apoptosis-related cysteine peptidase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0100
ORGANISM:human
Entrez Gene ID:837
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.57 :: 2.67 :: 1.64 :: 0.83 :: -2.65 :: -2.89 :: -2.04
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
837GO:0005515IEAFunctionprotein binding
837GO:0005622IEAComponentintracellular
837GO:0005737NRComponentcytoplasm
837GO:0006508IEAProcessproteolysis
837GO:0006508TASProcessproteolysis
837GO:0006917TASProcessinduction of apoptosis
837GO:0008234IEAFunctioncysteine-type peptidase activity
837GO:0030693IEAFunctioncaspase activity
837GO:0042981IEAProcessregulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5272NP_004146.1serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9HPRD03480
-10392NP_006083.1caspase recruitment domain family, member 4HPRD05815
-23581NP_036246.1caspase 14 precursorHPRD05788
NP_001216.123581-Caspase 14HPRD04047
NP_001216.110392-NOD1HPRD04047
NP_001216.15272-Protease inhibitor 9HPRD04047
NP_001216.1837NP_001216.1caspase 4 isoform alpha precursorHPRD04047
NP_001216.11832NP_004406.1desmoplakinHPRD04047
NP_001216.11832NP_004406.1desmoplakinHPRD00513
NP_001216.15663NP_015557.1presenilin 1 isoform I-463BIND130579
NP_001216.1843NP_116759.2caspase 10 isoform d preproproteinHPRD03458
NP_001216.1843NP_116759.2caspase 10 isoform d preproproteinHPRD04047
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
837CASP4_HUMANP49662IPR001315CARDCaspase Recruitment
837CASP4_HUMANP49662IPR001309ICE_p20Caspase, p20 subunit
837CASP4_HUMANP49662IPR011600Pept_C14_catPeptidase C14, caspase catalytic
837CASP4_HUMANP49662IPR002138Pept_C14_p10Peptidase C14, caspase non-catalytic subunit p10
837CASP4_HUMANP49662IPR002398Pept_C14_p45Peptidase C14, caspase precursor p45

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