Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8439
Official Symbol:NSMAF
Other Aliases:FAN
See related:HGNC:8017|MIM:603043|HPRD:09117
Chromosome:8
Location:8q12-q13
Gene Description:neutral sphingomyelinase (N-SMase) activation associated factor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0179
ORGANISM:human
Entrez Gene ID:8439
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0223
ORGANISM:human
Entrez Gene ID:8439
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18201CBCerebellum7.843770980834967.38759183883667
18201CTXCerebral cortex11.15735340118417.41399955749512
18201HIPHippocampal region9.808474540710458.09393119812012
18201HPFHippocampal formation9.643516540527347.19197702407837
18201HYHypothalamus14.16644859313969.47318840026855
18201LSXLateral septal complex4.755126476287843.20779347419739
18201MBMidbrain20.420001983642616.8182582855225
18201MYMedulla24.373910903930725.3485851287842
18201OLFOlfactory bulb10.1527204513556.64988565444946
18201PPons22.89627647399921.4967880249023
18201PALPallidum11.86981487274179.2084789276123
18201RHPRetrohippocampal region9.593442916870125.97874546051025
18201sAMYStriatum-like amygdalar nuclei12.908497810363811.8473024368286
18201STRStriatum5.184618473052983.73388504981995
18201STRdStriatum dorsal region3.386414527893072.24876880645752
18201STRvStriatum ventral region6.899672031402594.24965810775757
18201THThalamus8.696471214294436.01792860031128
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8439GO:0005057TASFunctionreceptor signaling protein activity
8439GO:0005625TASComponentsoluble fraction
8439GO:0005737TASComponentcytoplasm
8439GO:0006672TASProcessceramide metabolism
8439GO:0007165TASProcesssignal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003571.210399-RACK1HPRD09117
NP_003571.210399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1BIND183546
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8439FAN_HUMANQ92636IPR000409Beige_BEACHBeige/BEACH
8439FAN_HUMANQ92636IPR004182GRAMGRAM
8439FAN_HUMANQ92636IPR000664Lethal2_giantLethal(2) giant larvae protein
8439FAN_HUMANQ92636IPR013577LLGL2Lethal giant larvae homologue 2
8439FAN_HUMANQ92636IPR001680WD40WD-40 repeat

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