Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8453
Official Symbol:CUL2
Other Aliases:MGC131970
See related:HGNC:2552|MIM:603135|HPRD:06786
Chromosome:10
Location:10p11.21
Gene Description:cullin 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0352
ORGANISM:human
Entrez Gene ID:8453
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:71745
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
71745CBCerebellum67.9968109130859100.0
71745CTXCerebral cortex100.0100.0
71745HIPHippocampal region100.0100.0
71745HPFHippocampal formation100.0100.0
71745HYHypothalamus84.299972534179790.1275634765625
71745LSXLateral septal complex67.788497924804757.8385620117188
71745MBMidbrain65.279335021972781.3485107421875
71745MYMedulla57.781616210937586.0405578613281
71745OLFOlfactory bulb100.0100.0
71745PPons64.222640991210987.6925048828125
71745PALPallidum100.0100.0
71745RHPRetrohippocampal region100.0100.0
71745sAMYStriatum-like amygdalar nuclei100.0100.0
71745STRStriatum100.0100.0
71745STRdStriatum dorsal region100.0100.0
71745STRvStriatum ventral region100.0100.0
71745THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8453GO:0000082TASProcessG1/S transition of mitotic cell cycle
8453GO:0005515IPIFunctionprotein binding
8453GO:0006512IEAProcessubiquitin cycle
8453GO:0007049IEAProcesscell cycle
8453GO:0007050TASProcesscell cycle arrest
8453GO:0008285TASProcessnegative regulation of cell proliferation
8453GO:0008629TASProcessinduction of apoptosis by intracellular signals
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9616NP_055060.1ring finger protein 7 isoform 1HPRD04840
NP_003582.29616-Ring finger protein 7HPRD06786
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8453CUL2_HUMANQ13617IPR001373CullinCullin

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