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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 8573 Official Symbol: CASK Other Aliases: LIN2 See related: HGNC:1497|MIM:300172|HPRD:02164 Chromosome: X Location: Xp11.4 Gene Description: calcium/calmodulin-dependent serine protein kinase (MAGUK family) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIM0327 ORGANISM: human Entrez Gene ID: 8573 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 15816859 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Nucleus Accumbens Drug Effects: Upregulated Fold Change: 0.59 Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 12361 CB Cerebellum 7.22159242630005 7.56091213226318 12361 CTX Cerebral cortex 5.935715675354 5.51613664627075 12361 HIP Hippocampal region 4.20100831985474 4.31998109817505 12361 HPF Hippocampal formation 4.2210431098938 3.76621103286743 12361 HY Hypothalamus 1.14823007583618 1.0621771812439 12361 LSX Lateral septal complex 1.14710819721222 1.31106722354889 12361 MB Midbrain 2.2153172492981 2.90046787261963 12361 MY Medulla 3.04370903968811 3.43092727661133 12361 OLF Olfactory bulb 16.7848300933838 12.7861576080322 12361 P Pons 5.84089994430542 7.78299856185913 12361 PAL Pallidum 1.17169773578644 1.26578068733215 12361 RHP Retrohippocampal region 4.37465906143188 3.08800792694092 12361 sAMY Striatum-like amygdalar nuclei 2.44527530670166 1.77312135696411 12361 STR Striatum 1.75446164608002 1.35126721858978 12361 STRd Striatum dorsal region 1.4930773973465 1.14100217819214 12361 STRv Striatum ventral region 2.49054050445557 1.83782517910004 12361 TH Thalamus 1.37782680988312 1.10214066505432 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 8573 GO:0000166 IEA Function nucleotide binding 8573 GO:0004385 TAS Function guanylate kinase activity 8573 GO:0004674 IEA Function protein serine/threonine kinase activity 8573 GO:0005515 IEA Function protein binding 8573 GO:0005516 IEA Function calmodulin binding 8573 GO:0005524 IEA Function ATP binding 8573 GO:0005886 TAS Component plasma membrane 8573 GO:0006468 IEA Process protein amino acid phosphorylation 8573 GO:0007155 TAS Process cell adhesion 8573 GO:0015629 TAS Component actin cytoskeleton 8573 GO:0016301 IEA Function kinase activity 8573 GO:0016740 IEA Function transferase activity Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 9369 CAC87720.2 neurexin 3-alpha HPRD 08989 - 8825 NP_004655.1 lin-7 homolog A HPRD 04542 - 9378 NP_004792.1 neurexin 1 isoform alpha precursor HPRD 11858 - 9378 NP_004792.1 neurexin 1 isoform alpha precursor HPRD 11858 - 10716 NP_006584.1 T-box, brain, 1 HPRD 07055 - 26047 NP_054860.1 cell recognition molecule Caspr2 precursor HPRD 05197 - 23705 NP_055148.2 immunoglobulin superfamily, member 4D HPRD 05746 - 9672 NP_055469.1 syndecan 3 HPRD 01719 - 9379 NP_055895.1 neurexin 2 isoform alpha-1 precursor HPRD 11859 - 57524 NP_065815.1 CASK interacting protein 1 HPRD 10809 - 64130 NP_071448.1 lin-7 homolog B HPRD 10040 - 85445 NP_207837.1 cell recognition protein CASPR4 isoform 1 HPRD 13079 - 50848 NP_653086.1 F11 receptor isoform a precursor HPRD 12038 NP_003679.1 - - Neurexin 1 HPRD 02164 NP_003679.1 - - Neurexin 2 HPRD 02164 NP_003679.1 - - Neurexin 3 HPRD 02164 NP_003679.1 - - JAM HPRD 02164 NP_003679.1 - - Caskin1 HPRD 02164 NP_003679.1 - - CASPR4 HPRD 02164 NP_003679.1 - - CIP98 HPRD 02164 NP_003679.1 8825 - Veli 1 HPRD 02164 NP_003679.1 9672 - Syndecan 3 HPRD 02164 NP_003679.1 10716 - T box brain 1 HPRD 02164 NP_003679.1 26047 - Contactin associated protein like 2 HPRD 02164 NP_003679.1 23705 - Immunoglobulin superfamily member 4 HPRD 02164 NP_003679.1 9873 NP_055639.1 FCH and double SH3 domains 2 HPRD 13321 NP_003679.1 22895 NP_055769.2 rabphilin 3A homolog HPRD 15273 NP_003679.1 25861 NP_056219.1 CASK-interacting protein CIP98 HPRD 09718 NP_003679.1 85461 NP_203752.1 TPR domain, ankyrin-repeat and coiled-coil-containing HPRD 18146 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 8573 IPR013543 CaMKII_AD Calcium/calmodulin dependent protein kinase II, association-domain 8573 IPR008144 Guanylate_kin Guanylate kinase 8573 IPR004172 L27 L27 8573 IPR001478 PDZ PDZ/DHR/GLGF 8573 IPR000719 Prot_kinase Protein kinase 8573 IPR001452 SH3 Src homology-3 8573 IPR011511 SH3_2 Variant SH3 8573 IPR013695 WAK Wall-associated kinase © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.