Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8573
Official Symbol:CASK
Other Aliases:LIN2
See related:HGNC:1497|MIM:300172|HPRD:02164
Chromosome:X
Location:Xp11.4
Gene Description:calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0327
ORGANISM:human
Entrez Gene ID:8573
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.59
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12361CBCerebellum7.221592426300057.56091213226318
12361CTXCerebral cortex5.9357156753545.51613664627075
12361HIPHippocampal region4.201008319854744.31998109817505
12361HPFHippocampal formation4.22104310989383.76621103286743
12361HYHypothalamus1.148230075836181.0621771812439
12361LSXLateral septal complex1.147108197212221.31106722354889
12361MBMidbrain2.21531724929812.90046787261963
12361MYMedulla3.043709039688113.43092727661133
12361OLFOlfactory bulb16.784830093383812.7861576080322
12361PPons5.840899944305427.78299856185913
12361PALPallidum1.171697735786441.26578068733215
12361RHPRetrohippocampal region4.374659061431883.08800792694092
12361sAMYStriatum-like amygdalar nuclei2.445275306701661.77312135696411
12361STRStriatum1.754461646080021.35126721858978
12361STRdStriatum dorsal region1.49307739734651.14100217819214
12361STRvStriatum ventral region2.490540504455571.83782517910004
12361THThalamus1.377826809883121.10214066505432
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8573GO:0000166IEAFunctionnucleotide binding
8573GO:0004385TASFunctionguanylate kinase activity
8573GO:0004674IEAFunctionprotein serine/threonine kinase activity
8573GO:0005515IEAFunctionprotein binding
8573GO:0005516IEAFunctioncalmodulin binding
8573GO:0005524IEAFunctionATP binding
8573GO:0005886TASComponentplasma membrane
8573GO:0006468IEAProcessprotein amino acid phosphorylation
8573GO:0007155TASProcesscell adhesion
8573GO:0015629TASComponentactin cytoskeleton
8573GO:0016301IEAFunctionkinase activity
8573GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9369CAC87720.2neurexin 3-alphaHPRD08989
-8825NP_004655.1lin-7 homolog AHPRD04542
-9378NP_004792.1neurexin 1 isoform alpha precursorHPRD11858
-9378NP_004792.1neurexin 1 isoform alpha precursorHPRD11858
-10716NP_006584.1T-box, brain, 1HPRD07055
-26047NP_054860.1cell recognition molecule Caspr2 precursorHPRD05197
-23705NP_055148.2immunoglobulin superfamily, member 4DHPRD05746
-9672NP_055469.1syndecan 3HPRD01719
-9379NP_055895.1neurexin 2 isoform alpha-1 precursorHPRD11859
-57524NP_065815.1CASK interacting protein 1HPRD10809
-64130NP_071448.1lin-7 homolog BHPRD10040
-85445NP_207837.1cell recognition protein CASPR4 isoform 1HPRD13079
-50848NP_653086.1F11 receptor isoform a precursorHPRD12038
NP_003679.1--Neurexin 1HPRD02164
NP_003679.1--Neurexin 2HPRD02164
NP_003679.1--Neurexin 3HPRD02164
NP_003679.1--JAMHPRD02164
NP_003679.1--Caskin1HPRD02164
NP_003679.1--CASPR4HPRD02164
NP_003679.1--CIP98HPRD02164
NP_003679.18825-Veli 1HPRD02164
NP_003679.19672-Syndecan 3HPRD02164
NP_003679.110716-T box brain 1HPRD02164
NP_003679.126047-Contactin associated protein like 2HPRD02164
NP_003679.123705-Immunoglobulin superfamily member 4HPRD02164
NP_003679.19873NP_055639.1FCH and double SH3 domains 2HPRD13321
NP_003679.122895NP_055769.2rabphilin 3A homologHPRD15273
NP_003679.125861NP_056219.1CASK-interacting protein CIP98HPRD09718
NP_003679.185461NP_203752.1TPR domain, ankyrin-repeat and coiled-coil-containingHPRD18146
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8573IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
8573IPR008144Guanylate_kinGuanylate kinase
8573IPR004172L27L27
8573IPR001478PDZPDZ/DHR/GLGF
8573IPR000719Prot_kinaseProtein kinase
8573IPR001452SH3Src homology-3
8573IPR011511SH3_2Variant SH3
8573IPR013695WAKWall-associated kinase

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