Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8611
Official Symbol:PPAP2A
Other Aliases:LLP1a|LPP1|PAP-2a|PAP2|PAP2a2|PAP2alpha2|PAPalpha1
See related:HGNC:9228|MIM:607124|HPRD:06178
Chromosome:5
Location:5q11
Gene Description:phosphatidic acid phosphatase type 2A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0588
ORGANISM:human
Entrez Gene ID:8611
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64369
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19012CBCerebellum1.366995990276342.16123086214066
19012CTXCerebral cortex0.3181568682193760.285120531916618
19012HIPHippocampal region0.3406812846660610.383127048611641
19012HPFHippocampal formation0.2850668728351590.34909975528717
19012HYHypothalamus0.3719821125268940.475036814808846
19012LSXLateral septal complex0.3526925295591350.239469394087791
19012MBMidbrain0.7128566503524780.927967190742493
19012MYMedulla5.296223640441898.50266265869141
19012OLFOlfactory bulb0.5556927323341370.505022794008255
19012PPons4.355534553527836.67041182518005
19012PALPallidum0.1663526818156240.197341129183769
19012RHPRetrohippocampal region0.1984189450740810.300963088870049
19012sAMYStriatum-like amygdalar nuclei0.4047043174505230.277603972703218
19012STRStriatum0.4835882186889650.448966667056084
19012STRdStriatum dorsal region0.537509664893150.512812092900276
19012STRvStriatum ventral region0.2678837254643440.241141341626644
19012THThalamus0.7835232615470890.820809632539749
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8611GO:0005624IDAComponentmembrane fraction
8611GO:0005886TASComponentplasma membrane
8611GO:0005887NASComponentintegral to plasma membrane
8611GO:0007205ISSProcessprotein kinase C activation
8611GO:0007205TASProcessprotein kinase C activation
8611GO:0008195IDAFunctionphosphatidate phosphatase activity
8611GO:0008195NASFunctionphosphatidate phosphatase activity
8611GO:0008285NASProcessnegative regulation of cell proliferation
8611GO:0008354TASProcessgerm cell migration
8611GO:0016787IEAFunctionhydrolase activity
8611GO:0019216ISSProcessregulation of lipid metabolism
8611GO:0019216NASProcessregulation of lipid metabolism
8611GO:0030521NASProcessandrogen receptor signaling pathway
8611GO:0046839TASProcessphospholipid dephosphorylation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003702.129966NP_055389.2nuclear autoantigenHPRD11613
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8611IPR000326Pesterase_PA_PTPPhosphoesterase, PA-phosphatase related
8611LPP1_HUMANO14494IPR002249Cl_channel7Chloride channel CLC-7
8611LPP1_HUMANO14494IPR000326Pesterase_PA_PTPPhosphoesterase, PA-phosphatase related

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