Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8612
Official Symbol:PPAP2C
Other Aliases:LPP2|PAP-2c|PAP2-g
See related:HGNC:9230|MIM:607126|HPRD:06180
Chromosome:19
Location:19p13
Gene Description:phosphatidic acid phosphatase type 2C
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0142
ORGANISM:human
Entrez Gene ID:8612
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.83 :: 2.02 :: 2.84 :: 2.51 :: -2.44 :: -2.00 :: 0.15
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
50784CBCerebellum0.2907932996749880.666363954544067
50784CTXCerebral cortex4.831762790679933.83730983734131
50784HIPHippocampal region2.13736557960512.33070492744446
50784HPFHippocampal formation1.671642065048221.75821328163147
50784HYHypothalamus1.42712748050691.58207952976227
50784LSXLateral septal complex0.2032399028539660.292890131473541
50784MBMidbrain1.72659897804262.76301217079163
50784MYMedulla0.5964824557304380.76240473985672
50784OLFOlfactory bulb0.568040847778320.763440430164337
50784PPons0.6070795655250552.20701050758362
50784PALPallidum0.8192580938339231.1255658864975
50784RHPRetrohippocampal region0.9048690199851990.914942026138306
50784sAMYStriatum-like amygdalar nuclei1.28319633007051.52007019519806
50784STRStriatum0.4476158320903780.515605568885803
50784STRdStriatum dorsal region0.2218572050333020.322384417057037
50784STRvStriatum ventral region0.6792371273040770.519129574298859
50784THThalamus1.555742502212521.35222065448761
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8612GO:0004721TASFunctionphosphoprotein phosphatase activity
8612GO:0008195IEAFunctionphosphatidate phosphatase activity
8612GO:0016020TASComponentmembrane
8612GO:0016021IEAComponentintegral to membrane
8612GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8612IPR000326Pesterase_PA_PTPPhosphoesterase, PA-phosphatase related
8612LPP2_HUMANO43688IPR000326Pesterase_PA_PTPPhosphoesterase, PA-phosphatase related

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