Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8788
Official Symbol:DLK1
Other Aliases:FA1|PREF1|Pref-1|ZOG|pG2
See related:HGNC:2907|MIM:176290|HPRD:01446
Chromosome:14
Location:14q32
Gene Description:delta-like 1 homolog (Drosophila)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0203
ORGANISM:human
Entrez Gene ID:8788
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13386CBCerebellum6.107994437217719.45058512687683
13386CTXCerebral cortex2.277512907981873.10213840007782
13386HIPHippocampal region3.128626763820656.17892360687256
13386HPFHippocampal formation6.1505546569824212.025514125824
13386HYHypothalamus84.761043548584100.0
13386LSXLateral septal complex52.938140869140678.3142547607422
13386MBMidbrain26.590535163879451.7679615020752
13386MYMedulla25.921525001525950.4217872619629
13386OLFOlfactory bulb9.9531350135803212.8055443763733
13386PPons28.424993515014651.3722305297852
13386PALPallidum38.485216140747159.1168918609619
13386RHPRetrohippocampal region10.433983325958318.9167184829712
13386sAMYStriatum-like amygdalar nuclei45.766910552978564.6633853912354
13386STRStriatum22.35221958160428.2753734588623
13386STRdStriatum dorsal region5.457622051239016.21157467365265
13386STRvStriatum ventral region49.645635604858454.0186042785645
13386THThalamus6.628325939178478.99263858795166
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8788GO:0005509IEAFunctioncalcium ion binding
8788GO:0005554NDFunctionmolecular function unknown
8788GO:0005615TASComponentextracellular space
8788GO:0005625TASComponentsoluble fraction
8788GO:0007275TASProcessdevelopment
8788GO:0016020IEAComponentmembrane
8788GO:0016021TASComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8788IPR000152Asx_hydroxyl_SAspartic acid and asparagine hydroxylation site
8788IPR001438EGF_2EGF-like, type 2
8788IPR000742EGF_3EGF-like, type 3
8788IPR013111EGF_extracellEGF, extracellular
8788IPR002049EGF_lamininEGF-like, laminin
8788IPR006209EGF_likeEGF-like
8788IPR013032EGF_like_regEGF-like region
8788DLK_HUMANP80370IPR000152Asx_hydroxyl_SAspartic acid and asparagine hydroxylation site
8788DLK_HUMANP80370IPR001438EGF_2EGF-like, type 2
8788DLK_HUMANP80370IPR000742EGF_3EGF-like, type 3
8788DLK_HUMANP80370IPR013111EGF_extracellEGF, extracellular
8788DLK_HUMANP80370IPR002049EGF_lamininEGF-like, laminin
8788DLK_HUMANP80370IPR006209EGF_likeEGF-like
8788DLK_HUMANP80370IPR013032EGF_like_regEGF-like region

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