Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:88
Official Symbol:ACTN2
Other Aliases:-
See related:HGNC:164|MIM:102573|HPRD:00019
Chromosome:1
Location:1q42-q43
Gene Description:actinin, alpha 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0078
ORGANISM:human
Entrez Gene ID:88
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.04 :: -0.03 :: 0.15 :: 0.43 :: 1.60 :: 0.63 :: 0.52 :: 0.66 :: 0.70 :: 0.33
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11472CBCerebellum0.00.0
11472CTXCerebral cortex0.00.0
11472HIPHippocampal region0.00.0
11472HPFHippocampal formation0.00.0
11472HYHypothalamus0.00.0
11472LSXLateral septal complex0.00.0
11472MBMidbrain0.00.0
11472MYMedulla0.00.0
11472OLFOlfactory bulb0.00.0
11472PPons0.00.0
11472PALPallidum0.00.0
11472RHPRetrohippocampal region0.00.0
11472sAMYStriatum-like amygdalar nuclei0.00.0
11472STRStriatum0.00.0
11472STRdStriatum dorsal region0.00.0
11472STRvStriatum ventral region0.00.0
11472THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
88GO:0003779IEAFunctionactin binding
88GO:0005509IEAFunctioncalcium ion binding
88GO:0005856NASComponentcytoskeleton
88GO:0005884TASComponentactin filament
88GO:0008307TASFunctionstructural constituent of muscle
88GO:0042802IPIFunctionidentical protein binding
88GO:0046983IDAFunctionprotein dimerization activity
88GO:0051289IDAProcessprotein homotetramerization
88GO:0051370IDAFunctionZASP binding
88GO:0051374IDAFunctionFATZ 1 binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6401NP_000441.1selectin E precursorHPRD00566
-2904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD00697
-1742NP_001356.1postsynaptic density protein 95HPRD04199
-8038NP_003465.2a disintegrin and metalloprotease domain 12 isoform 1 preproproteinHPRD04092
-8038NP_003465.2a disintegrin and metalloprotease domain 12 isoform 1 preproproteinHPRD04092
-1739NP_004078.1synapse-associated protein 97HPRD03007
-11155NP_009009.1LIM domain binding 3HPRD16172
-117178NP_054740.2synovial sarcoma, X breakpoint 2 interacting proteinHPRD10566
-23022NP_057165.2palladinHPRD09731
-51778NP_057683.1myozenin 2HPRD05724
-54869NP_060199.2epidermal growth factor receptor pathway substrate 8-like protein 1 isoform bHPRD13276
-27185NP_061132.1disrupted in schizophrenia 1HPRD05553
-58529NP_067068.1myozenin 1HPRD05725
-125950NP_597709.1RAVER1HPRD11484
CAB61269.1283NP_001136.1angiogenin, ribonuclease, RNase A family, 5 precursorBIND217822
NP_001094.1--ACTN3HPRD00019
NP_001094.16401-Selectin EHPRD00019
NP_001094.12904-N-methyl D-aspartate receptor subunit 2BHPRD00019
NP_001094.18038-ADAM 12HPRD00019
NP_001094.158529-Myozenin 1HPRD00019
NP_001094.151778-Myozenin 2HPRD00019
NP_001094.11742-Synapse associated protein 90HPRD00019
NP_001094.127185-DISC1HPRD00019
NP_001094.11739-Synapse associated protein 97HPRD00019
NP_001094.13741NP_002225.2potassium voltage-gated channel, shaker-related subfamily, member 5HPRD08888
NP_001094.1823NP_005177.2calpain 1, large subunitBIND218743
NP_001094.111155NP_009009.1LIM domain binding 3BIND185103
NP_001094.12902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorHPRD15926
NP_001094.12902NP_015566.1NMDA receptor 1 isoform NR1-3 precursorBIND315555
NP_001094.129967NP_038465.1suppression of tumorigenicityHPRD17447
NP_001094.127185NP_061132.1disrupted in schizophrenia 1BIND209098
NP_001094.19124NP_066272.1PDZ and LIM domain 1 (elfin)HPRD09326
NP_001094.19124NP_066272.1PDZ and LIM domain 1 (elfin)HPRD00019
NP_001094.158529NP_067068.1myozenin 1BIND182355
NP_001094.184665NP_115967.1myopalladinHPRD10536
NP_001094.191977NP_588612.1myozenin 3HPRD17624
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
88ACTN2_HUMANP35609IPR001589Actnin_actin_bdActin-binding, actinin-type
88ACTN2_HUMANP35609IPR001715Calponin_act_bdCalponin-like actin-binding
88ACTN2_HUMANP35609IPR013567EF_hand_assoc_2EF hand associated, type-2
88ACTN2_HUMANP35609IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
88ACTN2_HUMANP35609IPR013684Miro-likeMiro-like
88ACTN2_HUMANP35609IPR013623NADPH_OxNADPH oxidase Respiratory burst
88ACTN2_HUMANP35609IPR002017SpectrinSpectrin repeat

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