Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8824
Official Symbol:CES2
Other Aliases:CE-2|iCE
See related:HGNC:1864|MIM:605278|HPRD:07062
Chromosome:16
Location:16q22.1
Gene Description:carboxylesterase 2 (intestine, liver)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0132
ORGANISM:human
Entrez Gene ID:8824
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:0.86 :: 1.66 :: -0.04 :: 0.48 :: -2.04 :: -1.31 :: -1.30
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
234673CBCerebellum0.3300121128559110.68566507101059
234669CBCerebellum0.5453946590423580.762574255466461
102022CBCerebellum1.399664759635931.54977357387543
72361CBCerebellum16.553239822387720.644100189209
234671CBCerebellum2.506530761718753.4094762802124
234673CTXCerebral cortex0.4090850055217740.483067333698273
234671CTXCerebral cortex0.5024816393852230.632243037223816
102022CTXCerebral cortex0.5846591591835020.513807058334351
234669CTXCerebral cortex0.5879611968994140.966795265674591
72361CTXCerebral cortex8.458336830139165.8690333366394
234673HIPHippocampal region0.2577818930149080.247832685709
234669HIPHippocampal region0.4421594738960270.670095145702362
234671HIPHippocampal region0.6736180186271671.3366197347641
102022HIPHippocampal region1.132994294166561.19175112247467
72361HIPHippocampal region10.14928245544439.61944103240967
234673HPFHippocampal formation0.2178860604763030.203866466879845
234669HPFHippocampal formation0.4064448773860930.535606741905212
234671HPFHippocampal formation0.569548249244690.926657795906067
102022HPFHippocampal formation0.8995686769485470.865590453147888
72361HPFHippocampal formation9.862088203430188.46705150604248
234671HYHypothalamus0.05718585848808290.130015656352043
234673HYHypothalamus0.08943520486354830.10920899361372
102022HYHypothalamus0.3500998318195340.323685646057129
234669HYHypothalamus1.346445560455322.05566906929016
72361HYHypothalamus14.738671302795410.3751878738403
102022LSXLateral septal complex0.03341181948781010.0
234673LSXLateral septal complex0.1292800903320310.089507631957531
234671LSXLateral septal complex0.3076301813125610.187088161706924
234669LSXLateral septal complex1.207907199859621.84327292442322
72361LSXLateral septal complex15.274400711059611.9827938079834
234673MBMidbrain0.3244165182113650.437548756599426
234671MBMidbrain0.4723356664180761.04053056240082
102022MBMidbrain0.573744952678680.644028842449188
234669MBMidbrain0.6608060002326971.2713348865509
72361MBMidbrain6.023392200469975.28757238388062
234673MYMedulla0.5903362631797790.673804938793182
102022MYMedulla0.8264816403388980.841575562953949
234669MYMedulla1.624482393264772.14127635955811
72361MYMedulla12.161403656005910.5556592941284
234671MYMedulla9.6402015686035212.0201263427734
234671OLFOlfactory bulb0.3223011195659640.254849910736084
102022OLFOlfactory bulb0.9271099567413331.85452210903168
234673OLFOlfactory bulb1.057567596435551.45389091968536
234669OLFOlfactory bulb2.489229440689094.4777307510376
72361OLFOlfactory bulb22.737169265747118.7676467895508
234673PPons0.1061196774244310.11725851893425
102022PPons0.3438870608806610.386938184499741
234671PPons0.9784022569656371.12041103839874
72361PPons10.574309349060110.9067010879517
234669PPons2.627492904663093.97306156158447
234673PALPallidum0.08520179986953740.0981824472546577
234669PALPallidum0.3795433342456820.597205698490143
234671PALPallidum0.4205837845802310.370729595422745
102022PALPallidum0.5303788781166080.43628603219986
72361PALPallidum9.684556961059576.75724744796753
234673RHPRetrohippocampal region0.1502030640840530.116713628172874
234669RHPRetrohippocampal region0.2932761013507840.272615283727646
234671RHPRetrohippocampal region0.3549565970897670.298716574907303
102022RHPRetrohippocampal region0.5555110573768620.424994915723801
72361RHPRetrohippocampal region9.580582618713386.98748159408569
234673sAMYStriatum-like amygdalar nuclei0.1092751026153560.117865242063999
102022sAMYStriatum-like amygdalar nuclei0.3045422434806820.426726400852203
234671sAMYStriatum-like amygdalar nuclei0.7084731459617610.676223397254944
234669sAMYStriatum-like amygdalar nuclei0.8237625956535343.52513718605042
72361sAMYStriatum-like amygdalar nuclei7.702831745147716.41525745391846
234673STRStriatum0.09760423004627230.219875425100327
102022STRStriatum0.3983424305915830.344198137521744
234669STRStriatum0.5004456639289860.879330098628998
234671STRStriatum0.5436614155769350.659405946731567
72361STRStriatum7.992991447448735.91591691970825
234673STRdStriatum dorsal region0.08281850069761280.124548986554146
234669STRdStriatum dorsal region0.2878859937191010.284981101751328
102022STRdStriatum dorsal region0.3979140520095830.331628918647766
234671STRdStriatum dorsal region0.6808577179908750.877548635005951
72361STRdStriatum dorsal region2.731161594390871.90643668174744
234671STRvStriatum ventral region0.0764678642153740.13849064707756
234673STRvStriatum ventral region0.1348921358585360.708729386329651
234669STRvStriatum ventral region0.5033261179924010.551690697669983
102022STRvStriatum ventral region0.5587140321731570.356615900993347
72361STRvStriatum ventral region20.045394897460913.6913204193115
234669THThalamus0.208706408739090.239450752735138
234673THThalamus0.2609336376190190.230010345578194
102022THThalamus0.391334086656570.348713666200638
234671THThalamus0.4696123301982880.614016532897949
72361THThalamus6.377968788146974.70838928222656
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8824GO:0004759IEAFunctionserine esterase activity
8824GO:0005783TASComponentendoplasmic reticulum
8824GO:0009056TASProcesscatabolism
8824GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8824EST2_HUMANO00748IPR002018CarbesteraseBCarboxylesterase, type B
8824EST2_HUMANO00748IPR000379Ser_estrsEsterase/lipase/thioesterase

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