Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8850
Official Symbol:PCAF
Other Aliases:CAF|GCN5|GCN5L|GCN5L1|P/CAF
See related:HGNC:8638|MIM:602303|HPRD:06780
Chromosome:3
Location:3p24
Gene Description:p300/CBP-associated factor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0038
ORGANISM:human
Entrez Gene ID:8850
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18519
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18519CBCerebellum6.462407112121585.98880624771118
18519CTXCerebral cortex0.5438106656074520.576040267944336
18519HIPHippocampal region0.285283058881760.297474771738052
18519HPFHippocampal formation0.3898928165435790.434284031391144
18519HYHypothalamus0.2817284762859340.152750626206398
18519LSXLateral septal complex0.2526259124279020.236832961440086
18519MBMidbrain1.751432657241821.85556733608246
18519MYMedulla4.110579490661622.9982476234436
18519OLFOlfactory bulb0.8931519985198970.522830367088318
18519PPons1.857406020164490.914248168468475
18519PALPallidum0.1859460473060610.0884029865264893
18519RHPRetrohippocampal region0.5339902043342590.630103409290314
18519sAMYStriatum-like amygdalar nuclei0.368205875158310.246202290058136
18519STRStriatum0.1594799309968950.12932924926281
18519STRdStriatum dorsal region0.0947333648800850.0699052140116692
18519STRvStriatum ventral region0.2206335514783860.192791596055031
18519THThalamus0.6974023580551150.896339297294617
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8850GO:0003712IPIFunctiontranscription cofactor activity
8850GO:0004402IEAFunctionhistone acetyltransferase activity
8850GO:0005515IPIFunctionprotein binding
8850GO:0005634TASComponentnucleus
8850GO:0006338NASProcesschromatin remodeling
8850GO:0006350IEAProcesstranscription
8850GO:0006355IEAProcessregulation of transcription, DNA-dependent
8850GO:0006473TASProcessprotein amino acid acetylation
8850GO:0007049IEAProcesscell cycle
8850GO:0007050TASProcesscell cycle arrest
8850GO:0008080IEAFunctionN-acetyltransferase activity
8850GO:0008285IDAProcessnegative regulation of cell proliferation
8850GO:0016740IEAFunctiontransferase activity
8850GO:0042826IPIFunctionhistone deacetylase binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-51621NP_057079.1Kruppel-like factor 13HPRD05620
-122953NP_569736.1Jun dimerization proteinHPRD16360
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.2155871NP_057853.1Tat--
NP_003875.3--NPAS2HPRD06780
NP_003875.351621-Kruppel like factor 13HPRD06780
NP_003875.310847NP_006653.1Snf2-related CBP activator proteinHPRD18103
NP_003875.3121504NP_778224.1histone H4BIND315283
NP_003875.310579NP_996743.1transforming, acidic coiled-coil containing protein 2 isoform bBIND196942
NP_003875.31489962NP_044282.1bel-1 proteinBIND182674
NP_003875.3155871NP_057853.1TatBIND144544
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8850PCAF_HUMANQ92831IPR001487BromodomainBromodomain
8850PCAF_HUMANQ92831IPR000182GCN5acetyl_transGCN5-related N-acetyltransferase
8850PCAF_HUMANQ92831IPR009464PCAF_NPCAF, N-terminal

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