Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8851
Official Symbol:CDK5R1
Other Aliases:CDK5P35|CDK5R|MGC33831|NCK5A|p23|p25|p35|p35nck5a
See related:HGNC:1775|MIM:603460|HPRD:04586
Chromosome:17
Location:17q11.2
Gene Description:cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0910
ORGANISM:human
Entrez Gene ID:8851
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8851GO:0000079TASProcessregulation of cyclin dependent protein kinase activity
8851GO:0001764ISSProcessneuron migration
8851GO:0004672TASFunctionprotein kinase activity
8851GO:0005509ISSFunctioncalcium ion binding
8851GO:0005515IPIFunctionprotein binding
8851GO:0005515ISSFunctionprotein binding
8851GO:0005624ISSComponentmembrane fraction
8851GO:0007158ISSProcessneuron adhesion
8851GO:0007213ISSProcessacetylcholine receptor signaling, muscarinic pathway
8851GO:0007411ISSProcessaxon guidance
8851GO:0007413ISSProcessaxonal fasciculation
8851GO:0007420ISSProcessbrain development
8851GO:0007420NASProcessbrain development
8851GO:0008283TASProcesscell proliferation
8851GO:0009790ISSProcessembryonic development
8851GO:0016020ISSComponentmembrane
8851GO:0016533IEAComponentcyclin-dependent protein kinase 5 activator complex
8851GO:0016534IEAFunctioncyclin-dependent protein kinase 5 activator activity
8851GO:0030424ISSComponentaxon
8851GO:0030426ISSComponentgrowth cone
8851GO:0031175ISSProcessneurite development
8851GO:0031594ISSComponentneuromuscular junction
8851GO:0035235ISSProcessionotropic glutamate receptor signaling pathway
8851GO:0043025ISSComponentcell soma
8851GO:0043197ISSComponentdendritic spine
8851GO:0043292ISSComponentcontractile fiber
8851GO:0043525ISSProcesspositive regulation of neuron apoptosis
8851GO:0043539ISSFunctionprotein serine/threonine kinase activator activity
8851GO:0045296ISSFunctioncadherin binding
8851GO:0045664NASProcessregulation of neuron differentiation
8851GO:0048675ISSProcessaxon extension
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10763NP_006608.1nestinHPRD09020
-22853NP_055731.2lemur tyrosine kinase 2HPRD13994
-84630NP_115927.1tau tubulin kinase 1HPRD11653
NP_003876.1--SETHPRD04586
NP_003876.1--C42HPRD04586
NP_003876.1--C48HPRD04586
NP_003876.1--C53HPRD04586
NP_003876.1--Alpha-actinin1HPRD04586
NP_003876.1--CaMKIIalphaHPRD04586
NP_003876.110763-NestinHPRD04586
NP_003876.18851NP_003876.1cyclin-dependent kinase 5, regulatory subunit 1HPRD04586
NP_003876.151654NP_057492.2CDK5 regulatory subunit associated protein 1 isoform aHPRD12189
NP_003876.151654NP_057492.2CDK5 regulatory subunit associated protein 1 isoform aHPRD12189
NP_003876.155755NP_060719.3CDK5 regulatory subunit associated protein 2HPRD09740
NP_003876.180279NP_788276.1CDK5 regulatory subunit associated protein 3 isoform bHPRD12190
NP_003876.180279NP_788276.1CDK5 regulatory subunit associated protein 3 isoform bHPRD12190
NP_003876.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8851CD5R1_HUMANQ15078IPR004944CDK5_activatorCyclin-dependent kinase 5 activator

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