Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8890
Official Symbol:EIF2B4
Other Aliases:DKFZp586J0119|EIF-2B|EIF2B|EIF2Bdelta
See related:HGNC:3260|MIM:606687|HPRD:09459
Chromosome:2
Location:2p23.3
Gene Description:eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0610
ORGANISM:human
Entrez Gene ID:8890
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:117019
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
13667CBCerebellum24.543205261230529.7314796447754
13667CTXCerebral cortex48.543972015380937.0106964111328
13667HIPHippocampal region45.576740264892646.8650398254395
13667HPFHippocampal formation55.800071716308651.4086990356445
13667HYHypothalamus22.651023864746117.1189556121826
13667LSXLateral septal complex22.729421615600615.8310136795044
13667MBMidbrain19.878530502319319.0951728820801
13667MYMedulla37.231986999511743.4305229187012
13667OLFOlfactory bulb59.383338928222747.897102355957
13667PPons36.206703186035241.6931190490723
13667PALPallidum25.543369293212925.7346382141113
13667RHPRetrohippocampal region78.97594451904362.3993301391602
13667sAMYStriatum-like amygdalar nuclei40.136089324951230.3895626068115
13667STRStriatum26.397663116455120.1483249664307
13667STRdStriatum dorsal region19.361618041992214.2754125595093
13667STRvStriatum ventral region43.016071319580133.6247100830078
13667THThalamus30.078599929809624.3879070281982
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8890GO:0003743IEAFunctiontranslation initiation factor activity
8890GO:0003743NASFunctiontranslation initiation factor activity
8890GO:0005851NASComponenteukaryotic translation initiation factor 2B complex
8890GO:0006413NASProcesstranslational initiation
8890GO:0006417NASProcessregulation of protein biosynthesis
8890GO:0044249IEAProcesscellular biosynthesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8893NP_003898.1eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDaHPRD04898
-8894NP_003899.2eukaryotic translation initiation factor 2 betaHPRD04882
-8892NP_055054.1eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDaHPRD05923
-8891NP_065098.1eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDaHPRD09379
NP_751945.1--EIF2B4HPRD09459
NP_751945.18892-eIF 2B, beta subunit 2HPRD09459
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8890EI2BD_HUMANQ9UI10IPR000649IF-2B_relatedInitiation factor 2B related

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