Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:8997
Official Symbol:KALRN
Other Aliases:DUET|FLJ16443|HAPIP|TRAD|duo
See related:HGNC:4814|MIM:604605|HPRD:06859|HPRD:12169
Chromosome:3
Location:3q21.1-q21.2
Gene Description:kalirin, RhoGEF kinase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0291
ORGANISM:human
Entrez Gene ID:8997
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:545156
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
8997GO:0000166IEAFunctionnucleotide binding
8997GO:0003824IEAFunctioncatalytic activity
8997GO:0004674IEAFunctionprotein serine/threonine kinase activity
8997GO:0004674TASFunctionprotein serine/threonine kinase activity
8997GO:0004713IEAFunctionprotein-tyrosine kinase activity
8997GO:0005089IEAFunctionRho guanyl-nucleotide exchange factor activity
8997GO:0005515ISSFunctionprotein binding
8997GO:0005524IEAFunctionATP binding
8997GO:0005622IEAComponentintracellular
8997GO:0006468IEAProcessprotein amino acid phosphorylation
8997GO:0006468TASProcessprotein amino acid phosphorylation
8997GO:0007165TASProcesssignal transduction
8997GO:0007242ISSProcessintracellular signaling cascade
8997GO:0007399ISSProcessnervous system development
8997GO:0015629TASComponentactin cytoskeleton
8997GO:0016192TASProcessvesicle-mediated transport
8997GO:0016740IEAFunctiontransferase activity
8997GO:0035023IEAProcessregulation of Rho protein signal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003938.127185--BIND259628
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
8997IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
8997IPR001251CRAL_bd_TRIO_CCellular retinaldehyde-binding/triple function, C-terminal
8997IPR003962FnIII_subdFibronectin, type III subdomain
8997IPR003961FN_IIIFibronectin, type III
8997IPR013098I-setImmunoglobulin I-set
8997IPR007110Ig-likeImmunoglobulin-like
8997IPR013151ImmunoglobulinImmunoglobulin
8997IPR001849PHPleckstrin-like
8997IPR000719Prot_kinaseProtein kinase
8997IPR000219RhoGEFDH
8997IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
8997IPR001452SH3Src homology-3
8997IPR011511SH3_2Variant SH3
8997IPR002017SpectrinSpectrin repeat
8997IPR001245Tyr_pkinaseTyrosine protein kinase
8997IPR013106V-setImmunoglobulin V-set
8997IPR013695WAKWall-associated kinase
8997DUET_HUMANQ9Y2A5IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
8997DUET_HUMANQ9Y2A5IPR003962FnIII_subdFibronectin, type III subdomain
8997DUET_HUMANQ9Y2A5IPR003961FN_IIIFibronectin, type III
8997DUET_HUMANQ9Y2A5IPR013098I-setImmunoglobulin I-set
8997DUET_HUMANQ9Y2A5IPR007110Ig-likeImmunoglobulin-like
8997DUET_HUMANQ9Y2A5IPR013151ImmunoglobulinImmunoglobulin
8997DUET_HUMANQ9Y2A5IPR001849PHPleckstrin-like
8997DUET_HUMANQ9Y2A5IPR000719Prot_kinaseProtein kinase
8997DUET_HUMANQ9Y2A5IPR000219RhoGEFDH
8997DUET_HUMANQ9Y2A5IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
8997DUET_HUMANQ9Y2A5IPR001245Tyr_pkinaseTyrosine protein kinase
8997DUET_HUMANQ9Y2A5IPR013106V-setImmunoglobulin V-set
8997DUET_HUMANQ9Y2A5IPR013695WAKWall-associated kinase
8997HAPIP_HUMANO60229IPR001251CRAL_bd_TRIO_CCellular retinaldehyde-binding/triple function, C-terminal
8997HAPIP_HUMANO60229IPR001849PHPleckstrin-like
8997HAPIP_HUMANO60229IPR000219RhoGEFDH
8997HAPIP_HUMANO60229IPR002017SpectrinSpectrin repeat

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