Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9040
Official Symbol:UBE2M
Other Aliases:UBC-RS2|UBC12|hUbc12
See related:HGNC:12491|MIM:603173|HPRD:04414
Chromosome:19
Location:19q13.43
Gene Description:ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0092
ORGANISM:human
Entrez Gene ID:9040
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.43 :: -0.32 :: 0.10 :: -0.03 :: -0.52 :: -0.14 :: -0.94 :: -0.74 :: -0.24 :: -1.02
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
22192CBCerebellum35.657432556152352.3233032226562
22192CTXCerebral cortex91.340484619140673.0417709350586
22192HIPHippocampal region60.361602783203184.873176574707
22192HPFHippocampal formation67.584861755371176.9788284301758
22192HYHypothalamus43.692924499511735.6053733825684
22192LSXLateral septal complex45.746402740478533.8739280700684
22192MBMidbrain42.358596801757840.9979133605957
22192MYMedulla39.321838378906248.8537979125977
22192OLFOlfactory bulb79.442939758300870.6665420532227
22192PPons40.357891082763747.3676376342773
22192PALPallidum58.681217193603559.8079872131348
22192RHPRetrohippocampal region79.841239929199268.1332015991211
22192sAMYStriatum-like amygdalar nuclei80.336715698242263.223705291748
22192STRStriatum54.938014984130940.3465538024902
22192STRdStriatum dorsal region50.176898956298836.8862113952637
22192STRvStriatum ventral region64.563682556152344.2982635498047
22192THThalamus45.158500671386742.3047752380371
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9040GO:0004842IEAFunctionubiquitin-protein ligase activity
9040GO:0006512IEAProcessubiquitin cycle
9040GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_003960.1131034NP_570720.1copine IVHPRD05017
NP_003960.1131034NP_570720.1copine IVHPRD04414
NP_003960.1221184NP_689940.3copine IIHPRD05015
NP_003960.1221184NP_689940.3copine IIHPRD04414
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9040UBC12_HUMANP61081IPR000608UBQ-conjugat_E2Ubiquitin-conjugating enzyme, E2

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