Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9146
Official Symbol:HGS
Other Aliases:HRS|ZFYVE8
See related:HGNC:4897|MIM:604375|HPRD:05085
Chromosome:17
Location:17q25
Gene Description:hepatocyte growth factor-regulated tyrosine kinase substrate
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0347
ORGANISM:human
Entrez Gene ID:9146
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:15239
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0187
ORGANISM:human
Entrez Gene ID:9146
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15239CBCerebellum41.720664978027351.1751441955566
15239CTXCerebral cortex92.38611602783278.8352355957031
15239HIPHippocampal region46.252479553222758.1273040771484
15239HPFHippocampal formation48.521907806396552.6396598815918
15239HYHypothalamus32.695976257324227.3012447357178
15239LSXLateral septal complex40.303348541259829.4233989715576
15239MBMidbrain35.305679321289134.4821548461914
15239MYMedulla52.254798889160261.2642555236816
15239OLFOlfactory bulb79.624610900878978.6531143188477
15239PPons37.935009002685545.5179977416992
15239PALPallidum46.282852172851646.3097610473633
15239RHPRetrohippocampal region52.848609924316445.49365234375
15239sAMYStriatum-like amygdalar nuclei61.94445037841849.4551124572754
15239STRStriatum53.752876281738342.1858253479004
15239STRdStriatum dorsal region55.573352813720743.6429328918457
15239STRvStriatum ventral region53.453899383544941.9165573120117
15239THThalamus54.607398986816449.5741844177246
KARG Evidence 3
KARG ID:QTL0187
Trait:chronic alcohol withdrawal severity
Peak:75
Peak Marker:D11Mit203
Parents:IP2 x IR1 F2
Evidence ID:12925894
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9146GO:0005768TASComponentendosome
9146GO:0006886IEAProcessintracellular protein transport
9146GO:0007165TASProcesssignal transduction
9146GO:0008270IEAFunctionzinc ion binding
9146GO:0008285TASProcessnegative regulation of cell proliferation
9146GO:0016020IEAComponentmembrane
9146GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004703.1--EPS15HPRD05085
NP_004703.155048NP_060436.4vacuolar protein sorting 37CHPRD15652
NP_004703.1137492NP_689628.1hepatocellular carcinoma related protein 1HPRD13410
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9146HGS_HUMANO14964IPR013591DZCDisease resistance/zinc finger/chromosome condensation-like region
9146HGS_HUMANO14964IPR003903UIMUbiquitin interacting motif
9146HGS_HUMANO14964IPR002014VHSVHS
9146HGS_HUMANO14964IPR000306Znf_FYVEZinc finger, FYVE-type

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