Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9191
Official Symbol:DEDD
Other Aliases:CASP8IP1|DEDD1|DEFT|FLDED1|KE05
See related:HGNC:2755|MIM:606841|HPRD:06022
Chromosome:1
Location:1q23.3
Gene Description:death effector domain containing
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0397
ORGANISM:human
Entrez Gene ID:9191
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:83631
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21945CBCerebellum35.471350193023762.2835578918457
21945CTXCerebral cortex83.29118728637783.6212692260742
21945HIPHippocampal region76.91742324829191.4454154968262
21945HPFHippocampal formation76.235553741455183.4318084716797
21945HYHypothalamus50.973219692707151.0695966482162
21945LSXLateral septal complex50.069690302014450.0631290450692
21945MBMidbrain55.720983982086256.9564409255981
21945MYMedulla51.6803536415152.7046711444855
21945OLFOlfactory bulb68.991147994995172.9282855987549
21945PPons53.240836381912254.8815002441406
21945PALPallidum41.889980554580751.1540693044662
21945RHPRetrohippocampal region75.33334541320873.3341064453125
21945sAMYStriatum-like amygdalar nuclei56.513929367065455.9648766517639
21945STRStriatum38.087582111358634.8579158782959
21945STRdStriatum dorsal region33.920228481292729.98029088974
21945STRvStriatum ventral region30.976992130279526.8999631404877
21945THThalamus57.773684501647960.1215496063232
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9191GO:0003677ISSFunctionDNA binding
9191GO:0005515IEAFunctionprotein binding
9191GO:0005515IPIFunctionprotein binding
9191GO:0005634IEAComponentnucleus
9191GO:0005730ISSComponentnucleolus
9191GO:0005737ISSComponentcytoplasm
9191GO:0006350IEAProcesstranscription
9191GO:0006355IEAProcessregulation of transcription, DNA-dependent
9191GO:0006917ISSProcessinduction of apoptosis
9191GO:0007283TASProcessspermatogenesis
9191GO:0008625TASProcessinduction of apoptosis via death domain receptors
9191GO:0016481ISSProcessnegative regulation of transcription
9191GO:0042981IEAProcessregulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_127491.1--FLAME-3HPRD06022
NP_127491.1--TFIIICHPRD06022
NP_127491.1162989NP_579874.1death effector domain-containing DNA binding protein 2HPRD10868
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9191DEDD_HUMANO75618IPR001875DEDDeath effector

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