Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9248
Official Symbol:GPR50
Other Aliases:H9|MGC125342
See related:HGNC:4506|MIM:300207|HPRD:02194
Chromosome:X
Location:Xq28
Gene Description:G protein-coupled receptor 50
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0193
ORGANISM:human
Entrez Gene ID:9248
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14765
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14765CBCerebellum2.330925107002263.52908569574356
14765CTXCerebral cortex2.540897876024252.27400529384613
14765HIPHippocampal region1.702076226472851.99080657958984
14765HPFHippocampal formation1.495716586709021.65992671251297
14765HYHypothalamus3.835101723670965.03528487682343
14765LSXLateral septal complex0.4657509922981260.930643491446972
14765MBMidbrain0.8449081182479861.11052054166794
14765MYMedulla1.751573920249942.26956474781036
14765OLFOlfactory bulb6.85023796558387.01806807518005
14765PPons1.334673464298251.99414956569672
14765PALPallidum1.540423870086671.51828062534332
14765RHPRetrohippocampal region1.211523711681371.23649878799915
14765sAMYStriatum-like amygdalar nuclei2.099945068359382.36320948600769
14765STRStriatum2.637050390243532.75627449154854
14765STRdStriatum dorsal region2.60697299242023.04212382435799
14765STRvStriatum ventral region3.761833012104032.73231652379036
14765THThalamus1.212198540568351.19095735251904
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9248GO:0004872IEAFunctionreceptor activity
9248GO:0005887TASComponentintegral to plasma membrane
9248GO:0007165IEAProcesssignal transduction
9248GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
9248GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
9248GO:0007267TASProcesscell-cell signaling
9248GO:0008502IEAFunctionmelatonin receptor activity
9248GO:0016020IEAComponentmembrane
9248GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9248MTR1L_HUMANQ13585IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
9248MTR1L_HUMANQ13585IPR000025Melatonin_rcptMelatonin receptor
9248MTR1L_HUMANQ13585IPR002280Mel_rcpt_1XMelatonin-related receptor type 1X
9248MTR1L_HUMANQ13585IPR000611NPY_rcptNeuropeptide Y receptor
9248MTR1L_HUMANQ13585IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap

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