Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9252
Official Symbol:RPS6KA5
Other Aliases:MGC1911|MSK1|MSPK1|RLPK
See related:HGNC:10434|MIM:603607|HPRD:06789
Chromosome:14
Location:14q31-q32.1
Gene Description:ribosomal protein S6 kinase, 90kDa, polypeptide 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0208
ORGANISM:human
Entrez Gene ID:9252
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:73086
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0297
ORGANISM:human
Entrez Gene ID:9252
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.54
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
73086CBCerebellum6.510068893432627.40712213516235
73086CTXCerebral cortex0.3211691677570340.305355221033096
73086HIPHippocampal region0.9155175089836120.75504595041275
73086HPFHippocampal formation0.5996310710906980.461491286754608
73086HYHypothalamus0.03930578008294110.0298902355134487
73086LSXLateral septal complex0.5017316341400150.337793856859207
73086MBMidbrain0.07822445780038830.0727438107132912
73086MYMedulla0.618964135646820.573011755943298
73086OLFOlfactory bulb1.704750061035161.58554923534393
73086PPons0.256018012762070.238536283373833
73086PALPallidum0.4339394569396970.336079061031342
73086RHPRetrohippocampal region0.1085989400744440.0830386504530907
73086sAMYStriatum-like amygdalar nuclei1.081566214561460.977729558944702
73086STRStriatum8.803823471069346.14696788787842
73086STRdStriatum dorsal region11.60979938507088.0617733001709
73086STRvStriatum ventral region5.441549777984624.14679145812988
73086THThalamus0.09324791282415390.094228096306324
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9252GO:0000166IEAFunctionnucleotide binding
9252GO:0003824IEAFunctioncatalytic activity
9252GO:0004674IDAFunctionprotein serine/threonine kinase activity
9252GO:0004674IEAFunctionprotein serine/threonine kinase activity
9252GO:0004713IEAFunctionprotein-tyrosine kinase activity
9252GO:0005515IPIFunctionprotein binding
9252GO:0005524IDAFunctionATP binding
9252GO:0005524IEAFunctionATP binding
9252GO:0005634IEPComponentnucleus
9252GO:0006355IDAProcessregulation of transcription, DNA-dependent
9252GO:0006468IEAProcessprotein amino acid phosphorylation
9252GO:0006508IEAProcessproteolysis
9252GO:0006950IEPProcessresponse to stress
9252GO:0007173TASProcessepidermal growth factor receptor signaling pathway
9252GO:0007243IDAProcessprotein kinase cascade
9252GO:0008237IEAFunctionmetallopeptidase activity
9252GO:0008270IEAFunctionzinc ion binding
9252GO:0009605IEPProcessresponse to external stimulus
9252GO:0016572IDAProcesshistone phosphorylation
9252GO:0016740IEAFunctiontransferase activity
9252GO:0042221IEPProcessresponse to chemical stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004746.2---BIND258670
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9252KS6A5_HUMANO75582IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
9252KS6A5_HUMANO75582IPR000183Decarbxylse2Orn/DAP/Arg decarboxylase 2
9252KS6A5_HUMANO75582IPR006025Pept_M_Zn_BSPeptidase M, neutral zinc metallopeptidases, zinc-binding site
9252KS6A5_HUMANO75582IPR000961Pkinase_CProtein kinase, C-terminal
9252KS6A5_HUMANO75582IPR000719Prot_kinaseProtein kinase
9252KS6A5_HUMANO75582IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
9252KS6A5_HUMANO75582IPR001245Tyr_pkinaseTyrosine protein kinase
9252KS6A5_HUMANO75582IPR013695WAKWall-associated kinase

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.