Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9294
Official Symbol:EDG5
Other Aliases:AGR16|EDG-5|Gpcr13|H218|LPB2|S1P2|S1PR2
See related:HGNC:3169|MIM:605111|HPRD:05488
Chromosome:19
Location:19p13.2
Gene Description:endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0350
ORGANISM:human
Entrez Gene ID:9294
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14739
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14739CBCerebellum14.492360115051315.9017820358276
14739CTXCerebral cortex16.872798919677711.6409969329834
14739HIPHippocampal region6.614633083343515.65288972854614
14739HPFHippocampal formation8.001911163330086.26927757263184
14739HYHypothalamus7.077193737030035.13497924804688
14739LSXLateral septal complex1.268648982048030.76769745349884
14739MBMidbrain15.29724884033213.2554054260254
14739MYMedulla23.685890197753923.5151252746582
14739OLFOlfactory bulb22.868801116943416.1938819885254
14739PPons17.032970428466815.985613822937
14739PALPallidum14.156483650207511.2494421005249
14739RHPRetrohippocampal region9.962462425231936.86520624160767
14739sAMYStriatum-like amygdalar nuclei17.530618667602511.1341533660889
14739STRStriatum10.25843715667726.56015825271606
14739STRdStriatum dorsal region8.069231986999515.25677585601807
14739STRvStriatum ventral region17.04058456420910.0937643051147
14739THThalamus19.547773361206114.4639158248901
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9294GO:0000187TASProcessactivation of MAPK activity
9294GO:0001619IEAFunctionlysosphingolipid and lysophosphatidic acid receptor activity
9294GO:0004872IEAFunctionreceptor activity
9294GO:0007165IEAProcesssignal transduction
9294GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
9294GO:0008284TASProcesspositive regulation of cell proliferation
9294GO:0008289TASFunctionlipid binding
9294GO:0016020IEAComponentmembrane
9294GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10672NP_006563.2guanine nucleotide binding protein (G protein), alpha 13HPRD05100
NP_004221.110672-Guanine nucleotide binding protein, alpha 13HPRD05488
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9294EDG5_HUMANO95136IPR002230Cnbnoid_rcptCannabinoid receptor
9294EDG5_HUMANO95136IPR000987EDG1_rcptEDG-1 sphingosine 1-phosphate receptor
9294EDG5_HUMANO95136IPR004063EDG5_rcptEDG-5 sphingosine 1-phosphate receptor
9294EDG5_HUMANO95136IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
9294EDG5_HUMANO95136IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
9294EDG5_HUMANO95136IPR004061S1P_rcptSphingosine 1-phosphate receptor

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