Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9365
Official Symbol:KL
Other Aliases:-
See related:HGNC:6344|MIM:604824|HPRD:05316
Chromosome:13
Location:13q12
Gene Description:klotho
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0082
ORGANISM:human
Entrez Gene ID:9365
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.76 :: 0.74 :: 0.33 :: 1.34 :: 0.81 :: -1.51 :: -0.37 :: 0.24 :: 0.51 :: 0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16591CBCerebellum19.499963283538826.9705109596252
16591CTXCerebral cortex15.834017515182511.1656556129456
16591HIPHippocampal region33.218388557434148.787260055542
16591HPFHippocampal formation24.669408798217830.549521446228
16591HYHypothalamus10.04297637939457.21812176704407
16591LSXLateral septal complex7.408617138862614.80252540111542
16591MBMidbrain10.07790732383738.61065793037415
16591MYMedulla26.430794715881330.6314783096313
16591OLFOlfactory bulb21.497203826904316.432071685791
16591PPons10.98684906959539.46331524848938
16591PALPallidum9.663514137268077.3662446141243
16591RHPRetrohippocampal region13.8225307464610.5083119869232
16591sAMYStriatum-like amygdalar nuclei13.313472628593412.0832808017731
16591STRStriatum11.80144238471989.69387447834015
16591STRdStriatum dorsal region10.81588482856759.15079781413078
16591STRvStriatum ventral region12.52400946617137.74196350574493
16591THThalamus13.409468650817913.4695014953613
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9365GO:0004566IEAFunctionbeta-glucuronidase activity
9365GO:0005179IEAFunctionhormone activity
9365GO:0005499IEAFunctionvitamin D binding
9365GO:0005975IEAProcesscarbohydrate metabolism
9365GO:0015926IEAFunctionglucosidase activity
9365GO:0016020IEAComponentmembrane
9365GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9365KLOT_HUMANQ9UEF7IPR001360Glyco_hydro_1Glycoside hydrolase, family 1

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