Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9414
Official Symbol:TJP2
Other Aliases:MGC26306|X104|ZO-2|ZO2
See related:HGNC:11828|MIM:607709|HPRD:06369
Chromosome:9
Location:9q13-q21
Gene Description:tight junction protein 2 (zona occludens 2)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0905
ORGANISM:human
Entrez Gene ID:9414
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21873CBCerebellum17.729028701782236.329761505127
21873CTXCerebral cortex3.1151590347292.38633608818054
21873HIPHippocampal region1.74161827564241.72002255916595
21873HPFHippocampal formation1.579536676406861.42103028297424
21873HYHypothalamus0.642238497734070.431533306837082
21873LSXLateral septal complex0.3473588228225710.369128108024597
21873MBMidbrain2.147538185119631.98586285114288
21873MYMedulla2.344385623931882.51460528373718
21873OLFOlfactory bulb1.634869217872622.40492630004883
21873PPons1.287839770317081.17379128932953
21873PALPallidum1.517805933952331.07102656364441
21873RHPRetrohippocampal region1.273396015167240.97650134563446
21873sAMYStriatum-like amygdalar nuclei0.6027984023094180.423236638307571
21873STRStriatum2.005697727203371.38365137577057
21873STRdStriatum dorsal region2.953948020935062.10885548591614
21873STRvStriatum ventral region0.7759388089179990.403679698705673
21873THThalamus2.336153030395511.71730434894562
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9414GO:0004385TASFunctionguanylate kinase activity
9414GO:0005515IEAFunctionprotein binding
9414GO:0005634IEAComponentnucleus
9414GO:0005887NRComponentintegral to plasma membrane
9414GO:0005923IEAComponenttight junction
9414GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-30011NP_114098.1SH3-domain kinase binding protein 1 isoform aHPRD02301
NP_004808.1155871NP_057853.1Tat--
NP_004808.2--CingulinHPRD06369
NP_004808.257530-CingulinHPRD06369
NP_004808.230011-SH3 domain kinase binding protein 1HPRD06369
NP_004808.257530NP_065821.1cingulinHPRD10827
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9414IPR008144Guanylate_kinGuanylate kinase
9414IPR001478PDZPDZ/DHR/GLGF
9414IPR001452SH3Src homology-3
9414IPR011511SH3_2Variant SH3
9414IPR005417ZonOcculdensZona occludens protein
9414IPR005419ZonOcculS2Zona occludens protein ZO-2
9414IPR005420ZonOcculS3Zona occludens protein ZO-3
9414ZO2_HUMANQ9UDY2IPR008144Guanylate_kinGuanylate kinase
9414ZO2_HUMANQ9UDY2IPR001478PDZPDZ/DHR/GLGF
9414ZO2_HUMANQ9UDY2IPR001452SH3Src homology-3
9414ZO2_HUMANQ9UDY2IPR011511SH3_2Variant SH3
9414ZO2_HUMANQ9UDY2IPR005417ZonOcculdensZona occludens protein
9414ZO2_HUMANQ9UDY2IPR005419ZonOcculS2Zona occludens protein ZO-2
9414ZO2_HUMANQ9UDY2IPR005420ZonOcculS3Zona occludens protein ZO-3

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