Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:945
Official Symbol:CD33
Other Aliases:FLJ00391|SIGLEC-3|SIGLEC3|p67
See related:HGNC:1659|MIM:159590|HPRD:01165
Chromosome:19
Location:19q13.3
Gene Description:CD33 molecule
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0300
ORGANISM:human
Entrez Gene ID:945
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.67
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
945GO:0004872TASFunctionreceptor activity
945GO:0005515IEAFunctionprotein binding
945GO:0005529IEAFunctionsugar binding
945GO:0005886TASComponentplasma membrane
945GO:0005887TASComponentintegral to plasma membrane
945GO:0007155NASProcesscell adhesion
945GO:0007165TASProcesssignal transduction
945GO:0007267TASProcesscell-cell signaling
945GO:0008285TASProcessnegative regulation of cell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5777NP_002822.2protein tyrosine phosphatase, non-receptor type 6 isoform 1HPRD01475
NP_001763.15777-SHP1HPRD01165
NP_001763.15781-SHP2HPRD01165
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
945CD33_HUMANP20138IPR013162CD80_C2_set_2CD80-like C2-set immunoglobulin
945CD33_HUMANP20138IPR007110Ig-likeImmunoglobulin-like
945CD33_HUMANP20138IPR013151ImmunoglobulinImmunoglobulin
945CD33_HUMANP20138IPR013106V-setImmunoglobulin V-set

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