Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:9568
Official Symbol:GABBR2
Other Aliases:FLJ36928|GABABR2|GPR51|GPRC3B|HG20
See related:HGNC:4507|MIM:607340|HPRD:09552
Chromosome:9
Location:9q22.1-q22.3
Gene Description:gamma-aminobutyric acid (GABA) B receptor, 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0153
ORGANISM:human
Entrez Gene ID:9568
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15759211
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVID0024
ORGANISM:human
Entrez Gene ID:9568
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:607340
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
54393CBCerebellum80.3576431274414100.0
54393CTXCerebral cortex100.0100.0
54393HIPHippocampal region100.0100.0
54393HPFHippocampal formation100.0100.0
54393HYHypothalamus100.0100.0
54393LSXLateral septal complex100.0100.0
54393MBMidbrain100.0100.0
54393MYMedulla100.0100.0
54393OLFOlfactory bulb100.0100.0
54393PPons100.0100.0
54393PALPallidum100.0100.0
54393RHPRetrohippocampal region100.0100.0
54393sAMYStriatum-like amygdalar nuclei100.0100.0
54393STRStriatum100.0100.0
54393STRdStriatum dorsal region100.0100.0
54393STRvStriatum ventral region100.0100.0
54393THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
9568GO:0004872IEAFunctionreceptor activity
9568GO:0004965TASFunctionGABA-B receptor activity
9568GO:0005887TASComponentintegral to plasma membrane
9568GO:0007165IEAProcesssignal transduction
9568GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
9568GO:0007194TASProcessnegative regulation of adenylate cyclase activity
9568GO:0007268TASProcesssynaptic transmission
9568GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-22809NP_036200.2activating transcription factor 5HPRD05906
NP_005449.522809-Activating transcription factor 5HPRD09552
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
9568GABR2_HUMANO75899IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
9568GABR2_HUMANO75899IPR002456GABAB1_rcptMetabotropic gamma-aminobutyric acid receptor, type B1
9568GABR2_HUMANO75899IPR002457GABAB2_rcptMetabotropic gamma-aminobutyric acid receptor, type B2
9568GABR2_HUMANO75899IPR002455GABAB_rcptMetabotropic gamma-aminobutyric acid receptor, type B
9568GABR2_HUMANO75899IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
9568GABR2_HUMANO75899IPR000694PRO_richProline-rich region

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