Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:960
Official Symbol:CD44
Other Aliases:CDW44|ECMR-III|IN|LHR|MC56|MDU2|MDU3|MGC10468|MIC4|MUTCH-I|Pgp1
See related:HGNC:1681|MIM:107269|HPRD:00115
Chromosome:11
Location:11p13
Gene Description:CD44 molecule (Indian blood group)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0853
ORGANISM:human
Entrez Gene ID:960
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12505CBCerebellum7.5474040508270311.1644759178162
12505CTXCerebral cortex0.6092779487371440.523921959102154
12505HIPHippocampal region0.9178660809993741.30709794163704
12505HPFHippocampal formation3.351610511541373.66491359472275
12505HYHypothalamus0.7810884714126590.836570501327515
12505LSXLateral septal complex0.2472671829164030.178901057690382
12505MBMidbrain0.2760598361492160.334428727626801
12505MYMedulla0.3189496248960490.426001965999603
12505OLFOlfactory bulb1.242603838443760.996612280607224
12505PPons0.508422233164310.51778344810009
12505PALPallidum0.9464224278926851.1454391926527
12505RHPRetrohippocampal region6.899851292371756.44922050833702
12505sAMYStriatum-like amygdalar nuclei1.06960630416871.17867749929428
12505STRStriatum1.325912863016131.22952204942703
12505STRdStriatum dorsal region1.323850527405741.22533541917801
12505STRvStriatum ventral region1.869373366236691.52081778645515
12505THThalamus0.8875076025724410.791075021028519
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
960GO:0004872IEAFunctionreceptor activity
960GO:0005518NASFunctioncollagen binding
960GO:0005540IEAFunctionhyaluronic acid binding
960GO:0005540NASFunctionhyaluronic acid binding
960GO:0005887NASComponentintegral to plasma membrane
960GO:0007155IEAProcesscell adhesion
960GO:0007160NASProcesscell-matrix adhesion
960GO:0016020IEAComponentmembrane
960GO:0016337NASProcesscell-cell adhesion
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23136AAC79806.1Homo sapiens putative lung tumor suppressor (DAL1) mRNA, complete cds.BIND217733
-2035AAD42222.1Homo sapiens protein 4.1 (EPB4.1) mRNA, complete cds.HPRD00558
-1839NP_001936.1heparin-binding EGF-like growth factorHPRD00526
-2247NP_001997.4fibroblast growth factor 2HPRD00622
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-4316NP_002414.1matrix metalloproteinase 7 preproproteinHPRD01525
-7074NP_003244.1T-cell lymphoma invasion and metastasis 1HPRD02820
-7410NP_003362.1vav 2 oncogeneHPRD02694
-7430NP_003370.2villin 2HPRD00475
-972NP_004346.1CD74 antigen isoform bHPRD00825
-1758NP_004398.1dentin matrix acidic phosphoproteinHPRD02989
-1956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD00579
-9138NP_945353.1Rho guanine nucleotide exchange factor 1 isoform 1HPRD03511
NP_000601.21839-Heparin binding EGF like growth factorHPRD00115
NP_000601.22247-Fibroblast growth factor 2HPRD00115
NP_000601.2972-CD74 antigenHPRD00115
NP_000601.25552-Proteoglycan 1HPRD00115
NP_000601.22534-FynHPRD00115
NP_000601.27074-T cell lymphoma invasion and metastasis 1HPRD00115
NP_000601.26696-Secreted phosphoprotein 1HPRD00115
NP_000601.27410-VAV2HPRD00115
NP_000601.24316-Matrix metalloproteinase 7HPRD00115
NP_000601.21758-Dentin matrix acidic phosphoproteinHPRD00115
NP_000601.27430-EzrinHPRD00115
NP_000601.21956-EGF receptorHPRD00115
NP_000601.29138-Rho guanine nucleotide exchange factor 1HPRD00115
NP_000601.21277NP_000079.1alpha 1 type I collagen preproproteinHPRD00115
NP_000601.21277NP_000079.1alpha 1 type I collagen preproproteinHPRD00362
NP_000601.21278NP_000080.1alpha 2 type I collagenHPRD00115
NP_000601.21278NP_000080.1alpha 2 type I collagenHPRD00363
NP_000601.24771NP_000259.1neurofibromin 2 isoform 1HPRD00115
NP_000601.24771NP_000259.1neurofibromin 2 isoform 1HPRD06980
NP_000601.26401NP_000441.1selectin E precursorHPRD00115
NP_000601.26401NP_000441.1selectin E precursorHPRD00566
NP_000601.23486NP_000589.1insulin-like growth factor binding protein 3HPRD00115
NP_000601.23486NP_000589.1insulin-like growth factor binding protein 3HPRD00899
NP_000601.27048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD00115
NP_000601.27048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD01823
NP_000601.21445NP_004374.1c-src tyrosine kinaseHPRD00115
NP_000601.21445NP_004374.1c-src tyrosine kinaseHPRD00496
NP_000601.21462NP_004376.2chondroitin sulfate proteoglycan 2 (versican)HPRD00115
NP_000601.21462NP_004376.2chondroitin sulfate proteoglycan 2 (versican)HPRD00340
NP_000601.27046NP_004603.1transforming growth factor, beta receptor I precursorHPRD00115
NP_000601.27046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01822
NP_000601.24318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00115
NP_000601.24318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00387
NP_000601.21956NP_005219.2epidermal growth factor receptor isoform aBIND130543
NP_000601.22066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD00115
NP_000601.22066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD02767
NP_000601.23932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD00115
NP_000601.23932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD01080
NP_000601.27373NP_066933.1collagen, type XIV, alpha 1HPRD00379
NP_000601.27373NP_066933.1collagen, type XIV, alpha 1HPRD00115
NP_000601.28174NP_570117.1mucosal vascular addressin cell adhesion molecule 1 isoform a precursorHPRD00115
NP_000601.28174NP_570117.1mucosal vascular addressin cell adhesion molecule 1 isoform a precursorHPRD00035
NP_000601.2155807NP_057852.2Vpr--
NP_000601.31839-Heparin binding EGF like growth factorHPRD00115
NP_000601.32247-Fibroblast growth factor 2HPRD00115
NP_000601.3972-CD74 antigenHPRD00115
NP_000601.35552-Proteoglycan 1HPRD00115
NP_000601.32534-FynHPRD00115
NP_000601.37074-T cell lymphoma invasion and metastasis 1HPRD00115
NP_000601.36696-Secreted phosphoprotein 1HPRD00115
NP_000601.37410-VAV2HPRD00115
NP_000601.34316-Matrix metalloproteinase 7HPRD00115
NP_000601.31758-Dentin matrix acidic phosphoproteinHPRD00115
NP_000601.37430-EzrinHPRD00115
NP_000601.31956-EGF receptorHPRD00115
NP_000601.39138-Rho guanine nucleotide exchange factor 1HPRD00115
NP_000601.32035-Erythrocyte membrane protein band 4.1HPRD00115
NP_000601.31277NP_000079.1alpha 1 type I collagen preproproteinHPRD00115
NP_000601.31278NP_000080.1alpha 2 type I collagenHPRD00115
NP_000601.34771NP_000259.1neurofibromin 2 isoform 1HPRD00115
NP_000601.36401NP_000441.1selectin E precursorHPRD00115
NP_000601.33486NP_001013416.1insulin-like growth factor binding protein 3 isoform a precursorHPRD00115
NP_000601.37048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD00115
NP_000601.31445NP_004374.1c-src tyrosine kinaseHPRD00115
NP_000601.31462NP_004376.2chondroitin sulfate proteoglycan 2 (versican)HPRD00115
NP_000601.37046NP_004603.1transforming growth factor, beta receptor I precursorHPRD00115
NP_000601.34318NP_004985.1matrix metalloproteinase 9 preproproteinHPRD00115
NP_000601.32066NP_005226.1v-erb-a erythroblastic leukemia viral oncogene homolog 4HPRD00115
NP_000601.33932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD00115
NP_000601.37373NP_066933.1collagen, type XIV, alpha 1HPRD00115
NP_000601.38174NP_570117.1mucosal vascular addressin cell adhesion molecule 1 isoform a precursorHPRD00115
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
960IPR001231CD44_antigenCD44 antigen
960IPR001782Flag_FlgIFlagellar P-ring protein
960IPR000538LinkLink
960CD44_HUMANP16070IPR001231CD44_antigenCD44 antigen
960CD44_HUMANP16070IPR000538LinkLink

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