Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:999
Official Symbol:CDH1
Other Aliases:Arc-1|CD324|CDHE|ECAD|LCAM|UVO
See related:HGNC:1748|MIM:192090
Chromosome:16
Location:16q22.1
Gene Description:cadherin 1, type 1, E-cadherin (epithelial)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0115
ORGANISM:human
Entrez Gene ID:999
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.53 :: 1.40 :: 0.64 :: 0.89 :: -2.12 :: -2.64 :: -2.44
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12550CBCerebellum1.609402298927312.59638905525208
12550CTXCerebral cortex0.6004373431205750.792162477970123
12550HIPHippocampal region0.2889163792133330.377008706331253
12550HPFHippocampal formation0.370785951614380.403058230876923
12550HYHypothalamus0.05928113311529160.0560376830399036
12550LSXLateral septal complex0.00.0
12550MBMidbrain0.3467077314853670.369899481534958
12550MYMedulla0.271419972181320.340814977884293
12550OLFOlfactory bulb1.113282680511471.9760410785675
12550PPons0.2009448558092120.412043511867523
12550PALPallidum0.1773755699396130.378418833017349
12550RHPRetrohippocampal region0.5072042346000670.450390368700027
12550sAMYStriatum-like amygdalar nuclei0.1100006029009820.130017548799515
12550STRStriatum0.06855279207229610.0889846980571747
12550STRdStriatum dorsal region0.06087116524577140.07927355915308
12550STRvStriatum ventral region0.07321379333734510.110519222915173
12550THThalamus0.08450102806091310.0808456242084503
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
999GO:0005509IEAFunctioncalcium ion binding
999GO:0005515IEAFunctionprotein binding
999GO:0005554NDFunctionmolecular function unknown
999GO:0007155IEAProcesscell adhesion
999GO:0007156IEAProcesshomophilic cell adhesion
999GO:0007156NASProcesshomophilic cell adhesion
999GO:0016020IEAComponentmembrane
999GO:0016021IEAComponentintegral to membrane
999GO:0016021NASComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5310NP_000287.2polycystin 1 isoform 2 precursorHPRD03203
-3695NP_000880.1integrin, beta 7HPRD00948
-7430NP_003370.2villin 2HPRD00475
-1956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD00579
-5784NP_005392.2protein tyrosine phosphatase, non-receptor type 14HPRD04402
-3667NP_005535.1insulin receptor substrate 1HPRD00943
-10096NP_005712.1ARP3 actin-related protein 3 homologHPRD05024
-4739NP_006394.1neural precursor cell expressed, developmentally down-regulated 9 isoform 1HPRD11888
-10672NP_006563.2guanine nucleotide binding protein (G protein), alpha 13HPRD05100
-2768NP_031379.1guanine nucleotide binding protein (G protein) alpha 12HPRD05093
-9743NP_055530.2Rho GTPase-activating proteinHPRD12257
-51762NP_057614.1RAB8B, member RAS oncogene familyHPRD11476
-79872NP_079090.1Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1HPRD07590
BAA88957.1--Protein Tyrosine Phosphatase PTPmuHPRD01885
BAA88957.13728-Catenin, gammaHPRD01885
BAA88957.17430-EzrinHPRD01885
BAA88957.11956-EGF receptorHPRD01885
BAA88957.13667-IRS 1HPRD01885
BAA88957.110672-Guanine nucleotide binding protein, alpha 13HPRD01885
BAA88957.12768-Guanine nucleotide binding protein, alpha 12HPRD01885
BAA88957.15310-Polycystin 1HPRD01885
BAA88957.179872-HAKAIHPRD01885
BAA88957.110096-Actin related protein 3HPRD01885
BAA88957.15784-Protein-tyrosine phosphatase pezHPRD01885
BAA88957.155914AAK69431.1densin-180-like proteinHPRD01885
BAA88957.155914AAK69431.1densin-180-like proteinHPRD06090
BAA88957.1999BAA88957.1E-cadherinHPRD01885
BAA88957.13695NP_000880.1integrin, beta 7HPRD01885
BAA88957.11434NP_001307.2CSE1 chromosome segregation 1-like proteinHPRD03217
BAA88957.11434NP_001307.2CSE1 chromosome segregation 1-like proteinHPRD01885
BAA88957.11500NP_001322.1catenin (cadherin-associated protein), delta 1HPRD01885
BAA88957.11500NP_001322.1catenin (cadherin-associated protein), delta 1HPRD03026
BAA88957.11499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaHPRD01885
BAA88957.11499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaHPRD00286
BAA88957.15792NP_002831.1protein tyrosine phosphatase, receptor type, F isoform 1 precursorHPRD01885
BAA88957.15792NP_002831.1protein tyrosine phosphatase, receptor type, F isoform 1 precursorHPRD01552
BAA88957.18826NP_003861.1IQ motif containing GTPase activating protein 1HPRD04541
BAA88957.18826NP_003861.1IQ motif containing GTPase activating protein 1HPRD01885
BAA88957.11739NP_004078.1synapse-associated protein 97HPRD01885
BAA88957.11739NP_004078.1synapse-associated protein 97HPRD03007
BAA88957.155591NP_060069.2transmembrane protein vezatinHPRD11671
BAA88957.155966NP_061324.1transmembrane protein SHREW1HPRD15339
L34545.13020NP_002098.1H3 histone, family 3ABIND169346
NC_000016.86935NP_110378.2transcription factor 8 (represses interleukin 2 expression)BIND258651
NP_004351.11500AAC39822.1Homo sapiens p120 catenin isoform 3AC (CTNND1) mRNA, alternatively spliced, complete cds.BIND259673
NP_004351.11499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaBIND216017
NP_004351.11499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaBIND151821
NP_004351.11499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaBIND183837
NP_004351.11956NP_005219.2epidermal growth factor receptor isoform aBIND57962
NP_004351.1155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
999CADH1_HUMANP12830IPR002126CadherinCadherin
999CADH1_HUMANP12830IPR000233Cadherin_C_termCadherin cytoplasmic region
999CADH1_HUMANP12830IPR009124DesmocollinDesmocollin
999CADH1_HUMANP12830IPR013585ProtocadherinProtocadherin

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