Knowledgebase for Addiction-Related Genes
   Home | Score | Chromosome | Genetics | Pathway | Advanced Search | BLAST | Downloads | Publications | F.A.Q | 
KARG GWAS (Genomewide Association Studies) of Drug Addiction (Homo Sapiens) (Click to see Low Scale data)
We identified 10 GWAS studies focused on drug addiction, with 11 independent samples. 5 of them can meet our inclusion criteria. Initial data analyses were performed to access the vulnerability of each SNP marker, following the protocols published before. We integrated these 11 GWAS datasets using a meta-signature-based approach. 842 SNPs were identified with at least three items of positive evidence and meta-false discovery rate less than 0.05. Since most of these genetic vulnerable markers are in fact genetic 'tag markers' instead of functional variations, we further expanded this list to 1,907 unique SNPs on the basis of the whole-genome linkage equilibrium data identified by HapMap. Finally, we integrated all available SNP functions to date and performed a comprehensive annotation to facilitate the interpretation of those addiction vulnerable variants identified by association studies. We identified 124 'functional' SNPs dropped into 70 hyplotype blocks. These functional SNPs include nonsynonymous/synonymous SNPs, SNPs introducing stop condon gain/frame-shift of peptides, SNPs putatively modifying transcription factor/microRNA binding or processes of alternative splicing, SNPs under positive or negative selections and SNPs with strong correlations with differentially gene expression.

*scoding: Synonymous SNP in coding regions; nscoding: Non-synonymous SNP in coding regions; stopgain: SNP introducing stop codon; frameshift: SNP introducing frame shift of open reading frame (ORF); splice: SNP potentially modify splicing junctions; tfbs: SNP potentially modifying transcription factor binding sites; miRNA: SNP potentially modifying miRNA binding sites ; express: SNP with identified strong correlation with differentially gene expression; positive: SNP under positive selection; negative: SNP under negative selection;
Haplotype ID Tag SNP Functional SNP Function Entrez Gene ID
HYPLO7 rs3124768 rs3124768 scoding,* 11093
HYPLO11 rs9565500 rs9565500 positive,  
HYPLO11 rs9565500 rs2095477 positive,  
HYPLO38 rs10424282 rs2278410 tfbs, 51231
HYPLO42 rs12569017 rs1994918 positive,  
HYPLO48 rs2869214 rs2869214 positive,  
HYPLO50 rs17534123 rs11557685 negative, 55339
HYPLO69 rs4132322 rs4132322 negative,  
HYPLO96 rs12971163 rs1116757 scoding, 79822
HYPLO96 rs12971163 rs4239328 negative,scoding, 79822
HYPLO102 rs680446 rs680446 negative,nscoding, 79784
HYPLO109 rs269095 rs269095 negative,  
HYPLO120 rs16830170 rs16830170 negative,scoding, 4703
HYPLO130 rs2694399 rs2694399 positive,  
HYPLO170 rs16946004 rs16946004 positive,  
HYPLO171 rs392692 rs386909 positive,  
HYPLO171 rs392692 rs1369867 positive,  
HYPLO171 rs392692 rs2482403 positive,  
HYPLO178 rs324420 rs324420 nscoding, 2166
HYPLO182 rs9321309 rs9321309 nscoding, 5169
HYPLO183 rs1044594 rs3214063 express, 9391
HYPLO183 rs1044594 rs3731930 express, 23020
HYPLO183 rs1044594 rs2276649 express,tfbs, 23020
HYPLO183 rs1044594 rs4907307 express, 55654
HYPLO183 rs1044594 rs2305935 express,nscoding, 9391
HYPLO183 rs1044594 rs11903461 express, 9391
HYPLO183 rs1044594 rs2279105 express,nscoding, 150771
HYPLO183 rs1044594 rs1048675 express,scoding, 150771
HYPLO183 rs1044594 rs3214058 express, 23020
HYPLO183 rs1044594 rs4907311 express, 9391
HYPLO183 rs1044594 rs17479466 express, 23020
HYPLO183 rs1044594 rs1044594 express, 9391
HYPLO183 rs1044594 rs17420101 express, 23020
HYPLO213 rs6726421 rs1366842 nscoding, 91752
HYPLO102 rs680446 rs680446 negative,nscoding, 79784
HYPLO109 rs269095 rs269095 negative,  
HYPLO11 rs9565500 rs2095477 positive,  
HYPLO11 rs9565500 rs9565500 positive,  
HYPLO120 rs16830170 rs16830170 negative,scoding, 4703
HYPLO130 rs2694399 rs2694399 positive,  
HYPLO170 rs16946004 rs16946004 positive,  
HYPLO171 rs392692 rs1369867 positive,  
HYPLO171 rs392692 rs2482403 positive,  
HYPLO171 rs392692 rs386909 positive,  
HYPLO178 rs324420 rs324420 nscoding, 2166
HYPLO182 rs9321309 rs9321309 nscoding, 5169
HYPLO183 rs1044594 rs1044594 express, 9391
HYPLO183 rs1044594 rs1048675 express,scoding, 150771
HYPLO183 rs1044594 rs11903461 express, 9391
HYPLO183 rs1044594 rs17420101 express, 23020
HYPLO183 rs1044594 rs17479466 express, 23020
HYPLO183 rs1044594 rs2276649 express,tfbs, 23020
HYPLO183 rs1044594 rs2279105 express,nscoding, 150771
HYPLO183 rs1044594 rs2305935 express,nscoding, 9391
HYPLO183 rs1044594 rs3214058 express, 23020
HYPLO183 rs1044594 rs3214063 express, 9391
HYPLO183 rs1044594 rs3731930 express, 23020
HYPLO183 rs1044594 rs4907307 express, 55654
HYPLO183 rs1044594 rs4907311 express, 9391
HYPLO213 rs6726421 rs1366842 nscoding, 91752
HYPLO213 rs6726421 rs4667001 nscoding, 91752
HYPLO215 rs16910202 rs3810910 scoding,  
HYPLO219 rs10132191 rs10132191 positive,  
HYPLO223 rs2576709 rs2576709 scoding, 4528
HYPLO258 rs1799971 rs1799971 nscoding, 4988
HYPLO289 rs11141978 rs11141978 negative,  
HYPLO291 rs4680 rs4680 nscoding, 51807
HYPLO293 rs17000819 rs17000819 nscoding, 94025
HYPLO294 rs2246462 rs1318150 positive,  
HYPLO294 rs2246462 rs2246462 positive,  
HYPLO294 rs2246462 rs285971 positive,  
HYPLO294 rs2246462 rs285975 positive,  
HYPLO308 rs7819201 rs1531298 express, 84955
HYPLO308 rs7819201 rs1993594 express, 84955
HYPLO308 rs7819201 rs2168964 express, 84955
HYPLO308 rs7819201 rs2926208 express, 84955
HYPLO308 rs7819201 rs2926214 express, 84955
HYPLO308 rs7819201 rs2926265 express, 84955
HYPLO308 rs7819201 rs2980589 express, 84955
HYPLO308 rs7819201 rs2980591 express, 84955
HYPLO308 rs7819201 rs2980619 express,nscoding, 84955
HYPLO308 rs7819201 rs2980620 express, 84955
HYPLO308 rs7819201 rs2980623 express, 84955
HYPLO316 rs2268084 rs6142078 positive,  
HYPLO320 rs10521229 rs16949576 negative,  
HYPLO335 rs16927574 rs16927574 scoding, 444
HYPLO352 rs1891034 rs1891034 negative, 79109
HYPLO354 rs1017154 rs1017154 tfbs, 55676
HYPLO357 rs9543543 rs7330557 positive,  
HYPLO357 rs9543543 rs7337014 positive,  
HYPLO357 rs9543543 rs9543540 positive,  
HYPLO367 rs6864342 rs6864342 nscoding, 1404
HYPLO38 rs10424282 rs2278410 tfbs, 51231
HYPLO387 rs16999608 rs16999608 negative,  
HYPLO388 rs1406236 rs4666194 positive, 238
HYPLO398 rs1719107 rs1719107 negative, 9179
HYPLO405 rs702764 rs702764 scoding, 4986
HYPLO407 rs6753025 rs6753025 negative,  
HYPLO416 rs35953316 rs35953316 negative,nscoding, 3176
HYPLO42 rs12569017 rs1994918 positive,  
HYPLO423 rs8112109 rs957738 scoding,  
HYPLO425 rs17035120 rs17035120 nscoding, 83468
HYPLO439 rs1140366 rs1140366 negative,scoding, 3908
HYPLO440 rs16827078 rs16827078 positive,scoding, 6018
HYPLO445 rs16945 rs2023748 scoding, 4233
HYPLO445 rs16945 rs41736 negative,scoding, 4233
HYPLO445 rs16945 rs41737 scoding, 4233
HYPLO445 rs16945 rs41738 mirna, 4233
HYPLO445 rs16945 rs42336 negative, 4233
HYPLO445 rs16945 rs6566 negative, 4233
HYPLO447 rs4341694 rs1058219 nscoding, 4644
HYPLO48 rs2869214 rs2869214 positive,  
HYPLO485 rs1162961 rs1300253 scoding, 55749
HYPLO487 rs9846894 rs4129158 positive, 254827
HYPLO487 rs9846894 rs9866564 nscoding, 254827
HYPLO50 rs17534123 rs11557685 negative, 55339
HYPLO503 rs1134975 rs1134975 negative,nscoding, 6542
HYPLO540 rs9946771 rs8091117 positive,nscoding, 1828
HYPLO560 rs1356373 rs10177444 negative, 27347
HYPLO570 rs515133 rs3734296 scoding, 23118
HYPLO570 rs515133 rs600739 positive, 387082
HYPLO570 rs515133 rs652921 mirna,scoding, 23118
HYPLO573 rs4669490 rs1054561 negative,scoding, 9014
HYPLO573 rs4669490 rs1054565 nscoding, 9014
HYPLO573 rs4669490 rs1820965 nscoding, 9014
HYPLO576 rs17082278 rs17082278 scoding, 23345
HYPLO594 rs913524 rs7917485 positive,  
HYPLO599 rs2296772 rs2296772 negative,scoding, 256691
HYPLO601 rs9493263 rs9493263 negative,  
HYPLO617 rs16948558 rs16948558 positive,  
HYPLO625 rs4090562 rs4090562 negative,  
HYPLO625 rs4090562 rs4547328 negative,  
HYPLO656 rs6265 rs6265 negative,nscoding, 627
HYPLO658 rs2876740 rs2763810 tfbs,  
HYPLO658 rs2876740 rs3187338 negative,  
HYPLO658 rs2876740 rs3742118 splice,  
HYPLO658 rs2876740 rs7327603 negative,scoding,  
HYPLO660 rs2544174 rs2598264 scoding, 9179
HYPLO685 rs3278 rs2029618 scoding, 9497
HYPLO69 rs4132322 rs4132322 negative,  
HYPLO691 rs4707570 rs16882046 negative,nscoding, 23195
HYPLO7 rs3124768 rs3124768 scoding, 11093
HYPLO705 rs500795 rs3826573 nscoding, 9150
HYPLO712 rs7788531 rs2214326 nscoding, 8701
HYPLO718 rs11700112 rs11700112 negative,nscoding, 57144
HYPLO779 rs7207469 rs16954056 negative,nscoding, 55275
HYPLO779 rs7207469 rs16954271 positive, 55275
HYPLO779 rs7207469 rs2279888 positive,negative, 55275
HYPLO779 rs7207469 rs7207469 positive, 55275
HYPLO779 rs7207469 rs7218263 positive, 55275
HYPLO779 rs7207469 rs7220509 positive, 55275
HYPLO779 rs7207469 rs8066036 positive, 55275
HYPLO799 rs2329072 rs2243497 positive,  
HYPLO799 rs2329072 rs2250256 positive,  
HYPLO799 rs2329072 rs2329072 positive,  
HYPLO800 rs2039369 rs6090471 scoding, 26205
HYPLO96 rs12971163 rs1116757 scoding, 79822
HYPLO96 rs12971163 rs4239328 negative,scoding, 79822
  Center for Bioinformatics(CBI), Peking University. Any Comments and suggestions to : KARG GROUP