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KARG >> Candidate Gene Association Studies of Drug Addiction (Homo Sapiens)                    Click to see GWAS data
We performed an integration and meta-analysis of candidate gene association studies of drug addiction. We retrieved 886 publications on candidate gene association studies of drug addiction from PubMed, among which 212 met our inclusion criteria.

Candidate Gene Association Studies of Drug Addiction
Allelic Contrast Test 1
KARG ID:ASSO0001PubMed ID15721218Year2005Author Name:Morita Y
Title:A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
Method:RFLPStudy Designcase-controlAddictive DrugMETH-dependenceBehavior:NA
Gene Name:FAAHMarker NamePro129ThrMarker InformationNAOriginal Report:nagative
Ethnic:JapaneseCase Sample Size153Control Sample Size200
Case Age:37.8+/-12.1Case Male%81%Control Age37.1+/-12.1Control Male%:81%
Case Minor:17.30%Case Major82.70%Case HWENA
Control Minorthr16%Control Major(84.0Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationICD-10-DCR
Allelic Contrast Test 2
KARG ID:ASSO0002PubMed ID15936534Year2005Author Name:Morita Y
Title:The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence
Method:RFLPStudy Designcase-controlAddictive DrugMETH-dependenceBehavior:NA
Gene Name:XBP-1Marker NameC-116/GMarker InformationNAOriginal Report:Nagative
Ethnic:JapaneseCase Sample Size153Control Sample Size200
Case Age:37.8+/-12.1Case Male%81.00%Control Age37.3+/-12.1Control Male%:84%
Case Minor:32%Case Major68%Case HWENA
Control MinorC38%Control MajorG62%Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationICD-10-DCR
Allelic Contrast Test 3
KARG ID:ASSO0003PubMed ID10064377Year1999Author Name:Hammoumi S
Title:Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent patients
Gene Name:5-HT1AMarker NameIle/Val Marker InformationIle>ValOriginal Report:negative
Ethnic:CaucasiansCase Sample Size104Control Sample Size38
Case Age:43.57+-1.43Case Male%71%Control Age43.8+-2.65Control Male%:64%
Case Minor:1Case Major113Case HWENA
Control Minor0Control Major74Control HWE:NA
Case AA:0Case AB1Case BB56
Control AA0Control AB0Control BB:37
Curator:CYLClinical InformationShort MAST criteria
Allelic Contrast Test 4
KARG ID:ASSO0004PubMed ID11920858Year2002Author Name:Li T
Title:"Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects"
Method:RFLPStudy Designcase-controlAddictive Drugheroine abuserBehavior:NA
Gene Name:5HT2AMarker NameNAMarker Information1438G/AOriginal Report:Nagative
Ethnic:NACase Sample Size121Control Sample Size194
Case Age:27.49+/-5.85Case Male%NAControl Age28.60+/-9.27Control Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationNA
Allelic Contrast Test 5
KARG ID:ASSO0005PubMed ID10064377Year1999Author Name:Hammoumi S
Title:Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent patients
Gene Name:5-HTTMarker Name17bp VNTRMarker Information12c>10cOriginal Report:negative
Ethnic:CaucasiansCase Sample Size104Control Sample Size38
Case Age:43.57+-1.43Case Male%71%Control Age43.8+-2.65Control Male%:64%
Case Minor:79Case Major105Case HWENA
Control Minor38Control Major32Control HWE:NA
Case AA:23Case AB33Case BB36
Control AA12Control AB14Control BB:9
Curator:CYLClinical InformationShort MAST criteria
Allelic Contrast Test 6
KARG ID:ASSO0006PubMed ID10064377Year1999Author Name:Hammoumi S
Title:Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent patients
Gene Name:5-HTTMarker Name5-HTTLPRMarker Information528>484Original Report:positive
Ethnic:CaucasiansCase Sample Size104Control Sample Size38
Case Age:43.57+-1.43Case Male%71%Control Age43.8+-2.65Control Male%:64%
Case Minor:93Case Major111Case HWENA
Control Minor22Control Major54Control HWE:NA
Case AA:25Case AB43Case BB34
Control AA4Control AB14Control BB:20
Curator:CYLClinical InformationShort MAST criteria
Allelic Contrast Test 7
KARG ID:ASSO0007PubMed ID10064377Year1999Author Name:Hammoumi S
Title:Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent patients
Gene Name:5-HTTMarker NamePstI RFLPMarker InformationA1>A2Original Report:negative
Ethnic:CaucasiansCase Sample Size104Control Sample Size38
Case Age:43.57+-1.43Case Male%71%Control Age43.8+-2.65Control Male%:64%
Case Minor:101Case Major107Case HWENA
Control Minor28Control Major28Control HWE:NA
Case AA:23Case AB55Case BB26
Control AA7Control AB14Control BB:7
Curator:CYLClinical InformationShort MAST criteria
Allelic Contrast Test 8
KARG ID:ASSO0008PubMed ID16691130Year2006Author Name:Francine Z.C
Title:Influence of the serotonin transporter gene on comorbid disorders among alcohol-dependent individuals
Method:RFLPStudy Designcase-controlAddictive DrugAlcohol-dependentBehavior:NA
Gene Name:5-HTT(SERT)Marker NameNAMarker InformationS/LalleleOriginal Report:Nagative
Ethnic:European Brazilian maleCase Sample Size114Control Sample Size218
Case Age:N.ACase Male%NAControl AgeNAControl Male%:NA
Case Minor:S48.2Case MajorL51.8Case HWENA
Control Minor45.4Control Major54.6Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 9
KARG ID:ASSO0009PubMed ID15066703Year2004Author Name:Konishi T
Title:"Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans"
Method:RFLPStudy Designcase-controlAddictive DrugAlcoholismBehavior:NA
Gene Name:5-HTTLPR S alleleMarker NameNAMarker InformationNAOriginal Report:positive
Ethnic:Mexican-AmericansCase Sample Size130Control Sample Size251
Case Age:38.2 +/- 11.8Case Male%100%Control Age32.5+/- 9.2Control Male%:41.80%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:L/L19 (14.6)Case ABL/S:62 (47.7)Case BBS/S:49 (37.7)
Control AA63 (25.1)Control AB111 (44.2)Control BB:77 (30.7)
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 10
KARG ID:ASSO0010PubMed ID15630072Year2005Author Name:Radel M
Title:Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster
Method:RFLPStudy Designcase-controlAddictive DrugalcoholismBehavior:NA
Gene Name:-Aminobutyric AcidMarker NameNAMarker Information"B2 1412C> T,T/C"Original Report:"positive,p=0.01"
Ethnic:Finnish CaucasiansCase Sample Size110Control Sample Size124
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:T30 (0.14)Case Major190 (0.86)Case HWENA
Control Minor17 (0.07)Control Major231 (0.93)Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 11
KARG ID:ASSO0011PubMed ID15630072Year2005Author Name:Radel M
Title:Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster
Method:RFLPStudy Designcase-controlAddictive DrugalcoholismBehavior:NA
Gene Name:-Aminobutyric AcidMarker NameNAMarker Information"B2 1412C> T,T/C"Original Report:"positive,p=0.008"
Ethnic:Southwestern Native AmericansCase Sample Size192Control Sample Size241
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:T215 (0.56)Case MajorC169 (0.44)Case HWENA
Control MinorT219 (0.45)Control Major263 (0.55)Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 12
KARG ID:ASSO0012PubMed ID15459944Year2005Author Name:Itoh K
Title:Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
Method:PCR-based restriction fragment length polymorphism (RFLP) assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine abusers
Gene Name:BDNFMarker Name132C?>?T in exon V (C270T named formerly) GCCGGGGAC-C-CGTGAGGTTTGTGTMarker InformationC>TOriginal Report:negative
Ethnic:JapaneseCase Sample Size189Control Sample Size202
Case Age:36.6+-11.9Case Male%79.40%Control Age37.2+-10.6Control Male%:78.20%
Case Minor:14Case Major364Case HWEYES
Control Minor19Control Major385Control HWE:YES
Case AA:0Case AB14Case BB175
Control AA0Control AB19Control BB:183
Curator:CYLClinical InformationICD-10-DCR criteria (F15.2 and F15.5)
Allelic Contrast Test 13
KARG ID:ASSO0013PubMed ID15666411Year2005Author Name:Liu QR
Title:"Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease"
Method:SequencingStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:BDNFMarker Namers11267088Marker InformationNAOriginal Report:positive
Ethnic:European- and African-American Case Sample Size285Control Sample Size202
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:206:1;210:1;212:2;214:5;218:0;220:1;226:1;228:5;230:75;232:245;234:120;236:80;238:30;240:3Case MajorNACase HWENA
Control Minor206:0;210:0;212:1;214:3;218:1;220:0;226:2;228:16;230:56;232:166;234:80;236:51;238:25;240:2Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical Information DSM-III-R dependence criteria for at least one illegal drug
Allelic Contrast Test 14
KARG ID:ASSO0014PubMed ID15547445Year2004Author Name:Matsushita S
Title:Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism
Method:PCR followed by digested by Pml IStudy Designcase-controlAddictive DrugalcoholBehavior:Alcoholic
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:negative
Ethnic:JapaneseCase Sample Size377Control Sample Size336
Case Age:49.9+-8.4Case Male%100%Control Age50.7+-17.8Control Male%:100%
Case Minor:296Case Major458Case HWEYES
Control Minor298Control Major374Control HWE:YES
Case AA:60Case AB176Case BB141
Control AA68Control AB162Control BB:106
Curator:CYLClinical InformationDSM-III-R to diagnose alcohol dependence
Allelic Contrast Test 15
KARG ID:ASSO0015PubMed ID15547445Year2004Author Name:Matsushita S
Title:Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism
Method:PCR followed by digested by Pml IStudy Designcase-controlAddictive DrugalcoholBehavior:Alcoholic Violence
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:JapaneseCase Sample Size58Control Sample Size319
Case Age:49.9+-8.4Case Male%100%Control Age50.7+-17.8Control Male%:100%
Case Minor:58Case Major58Case HWEYES
Control Minor238Control Major400Control HWE:YES
Case AA:16Case AB26Case BB16
Control AA44Control AB150Control BB:125
Curator:CYLClinical InformationDSM-III-R to diagnose alcohol dependence
Allelic Contrast Test 16
KARG ID:ASSO0016PubMed ID15547445Year2004Author Name:Matsushita S
Title:Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism
Method:PCR followed by digested by Pml IStudy Designcase-controlAddictive DrugalcoholBehavior:Alcoholic with Delirium Tremens
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:JapaneseCase Sample Size125Control Sample Size252
Case Age:49.9+-8.4Case Male%100%Control Age50.7+-17.8Control Male%:100%
Case Minor:115Case Major135Case HWEYES
Control Minor181Control Major323Control HWE:YES
Case AA:27Case AB61Case BB37
Control AA33Control AB115Control BB:104
Curator:CYLClinical InformationDSM-III-R to diagnose alcohol dependence
Allelic Contrast Test 17
KARG ID:ASSO0017PubMed ID15547445Year2004Author Name:Matsushita S
Title:Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism
Method:PCR followed by digested by Pml IStudy Designcase-controlAddictive DrugalcoholBehavior:Alcoholic with Epileptic seizure
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:JapaneseCase Sample Size44Control Sample Size333
Case Age:49.9+-8.4Case Male%100%Control Age50.7+-17.8Control Male%:100%
Case Minor:44Case Major44Case HWEYES
Control Minor252Control Major414Control HWE:YES
Case AA:11Case AB22Case BB11
Control AA49Control AB154Control BB:130
Curator:CYLClinical InformationDSM-III-R to diagnose alcohol dependence
Allelic Contrast Test 18
KARG ID:ASSO0018PubMed ID15666411Year2005Author Name:Liu QR
Title:"Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease"
Method:SequencingStudy Designcase-controlAddictive DrugalcoholBehavior:COGA
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:European-AmericanCase Sample Size285Control Sample Size202
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:14Case Major96Case HWENA
Control Minor43Control Major169Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical Information DSM-III-R dependence criteria for at least one illegal drug
Allelic Contrast Test 19
KARG ID:ASSO0019PubMed ID15459944Year2005Author Name:Itoh K
Title:Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
Method:PCR-based restriction fragment length polymorphism (RFLP) assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine abusers
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:negative
Ethnic:JapaneseCase Sample Size189Control Sample Size334
Case Age:36.6+-11.9Case Male%79.40%Control Age37.2+-10.6Control Male%:78.20%
Case Minor:142Case Major236Case HWEYES
Control Minor157Control Major511Control HWE:YES
Case AA:23Case AB96Case BB70
Control AA25Control AB107Control BB:202
Curator:CYLClinical InformationICD-10-DCR criteria (F15.2 and F15.5)
Allelic Contrast Test 20
KARG ID:ASSO0020PubMed ID17186223Year2007Author Name:Lang UE
Title:Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
Method:TaqMan nuclease assayStudy Designcase-controlAddictive DrugnicotineBehavior:smokers
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:German descentCase Sample Size114Control Sample Size139
Case Age:35.2+-12.1Case Male%NAControl Age38.4+-14.0Control Male%:48.40%
Case Minor:53Case Major175Case HWE"OK, P=0.873"
Control Minor38Control Major240Control HWE:"OK, P=0.873"
Case AA:6Case AB41Case BB67
Control AA4Control AB30Control BB:105
Curator:CYLClinical Informationassessed with a self-rating scale
Allelic Contrast Test 21
KARG ID:ASSO0021PubMed ID16109452Year2005Author Name:Cheng CY
Title:Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males
Method:RFLPStudy Designcase-controlAddictive DrugMETH-dependenceBehavior:NA
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:Han(taiwan)Case Sample Size103Control Sample Size122
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:31Case AB57Case BB15
Control AA23Control AB68Control BB:31
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 22
KARG ID:ASSO0022PubMed ID16109452Year2005Author Name:Cheng CY
Title:Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males
Method:RFLPStudy Designcase-controlAddictive Drugheroin-dependentBehavior:NA
Gene Name:BDNFMarker Namers6265Marker InformationG>AOriginal Report:positive
Ethnic:Han(taiwan)Case Sample Size200Control Sample Size122
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:62Case AB89Case BB49
Control AA23Control AB68Control BB:31
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 23
KARG ID:ASSO0023PubMed ID17189959Year2007Author Name:Ishiguro H
Title:Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:CB2Marker Namers2501432Marker InformationQ63Rtwo base pairs replacement polymorphismOriginal Report:positive
Ethnic:JapaneseCase Sample Size785Control Sample Size487
Case Age:51.2+/-9.1Case Male%667M/118FControl AgematchedControl Male%:matched
Case Minor:NACase MajorNACase HWEyes
Control Minor424Control Major550Control HWE:yes
Case AA:603Case ABNACase BB967
Control AA424Control ABNAControl BB:550
Curator:PWZClinical InformationDSM-IIIR criteria
Allelic Contrast Test 24
KARG ID:ASSO0024PubMed ID10235270Year1999Author Name:Okubo T
Title:Genetic association between alcohol withdrawal symptoms and polymorphism of CCK gene promoter
Method:PCR-direct sequencingStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol withdrawal with Delirium tremens
Gene Name:CCKMarker Name-45 C to TMarker InformationC>TOriginal Report:positive
Ethnic:JapaneseCase Sample Size52Control Sample Size195
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:35Case Major69Case HWENA
Control Minor106Control Major284Control HWE:NA
Case AA:2Case AB31Case BB19
Control AA16Control AB74Control BB:105
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 25
KARG ID:ASSO0025PubMed ID10235270Year2000Author Name:Okubo T
Title:Genetic association between alcohol withdrawal symptoms and polymorphism of CCK gene promoter
Method:PCR-direct sequencingStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol withdrawal with Hallucinosis
Gene Name:CCKMarker Name-45 C to TMarker InformationC>TOriginal Report:negative
Ethnic:JapaneseCase Sample Size39Control Sample Size195
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:21Case Major57Case HWENA
Control Minor106Control Major284Control HWE:NA
Case AA:0Case AB21Case BB18
Control AA16Control AB74Control BB:105
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 26
KARG ID:ASSO0026PubMed ID10235270Year2001Author Name:Okubo T
Title:Genetic association between alcohol withdrawal symptoms and polymorphism of CCK gene promoter
Method:PCR-direct sequencingStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol withdrawal with Seizures
Gene Name:CCKMarker Name-45 C to TMarker InformationC>TOriginal Report:negative
Ethnic:JapaneseCase Sample Size20Control Sample Size195
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:14Case Major26Case HWENA
Control Minor106Control Major284Control HWE:NA
Case AA:2Case AB10Case BB8
Control AA16Control AB74Control BB:105
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 27
KARG ID:ASSO0027PubMed ID10235270Year2002Author Name:Okubo T
Title:Genetic association between alcohol withdrawal symptoms and polymorphism of CCK gene promoter
Method:PCR-direct sequencingStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol withdrawal with No symptom
Gene Name:CCKMarker Name-45 C to TMarker InformationC>TOriginal Report:negative
Ethnic:JapaneseCase Sample Size92Control Sample Size195
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:58Case Major126Case HWENA
Control Minor106Control Major284Control HWE:NA
Case AA:11Case AB36Case BB45
Control AA16Control AB74Control BB:105
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 28
KARG ID:ASSO0028PubMed ID11509018Year2001Author Name:Comings DE
Title:Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples
Method:RFLP?Study Designcase-controlAddictive Drugever-snokedBehavior:NA
Gene Name:CCKMarker Name-45 C to TMarker InformationC>TOriginal Report:positive
Ethnic:NACase Sample Size120Control Sample Size71
Case Age:54.5+/-6.28Case Male%0Control Age54.5+/-6.28Control Male%:0
Case Minor:26.8%with T alleleCase MajorNACase HWENA
Control Minor15% with T allele(never -smoked)Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 29
KARG ID:ASSO0029PubMed ID11368834Year2001Author Name:Vanakoski J
Title:No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence.
Method:RFLPStudy Designcase-controlAddictive DrugAlcoholicsBehavior:NA
Gene Name:CCKMarker Name-45 C to TMarker InformationC>TOriginal Report:Nagative
Ethnic:finnishCase Sample Size107Control Sample Size150
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:0.09TCase Major0.91Case HWENA
Control Minor0.07Control Major0.93Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 30
KARG ID:ASSO0030PubMed ID11368834Year2001Author Name:Vanakoski J
Title:No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence.
Method:RFLPStudy Designcase-controlAddictive DrugAlcoholicsBehavior:NA
Gene Name:CCKBRMarker NameNAMarker InformationVal125IleOriginal Report:Nagative
Ethnic:finnishCase Sample Size102Control Sample Size146
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:0.06Case Major0.94Case HWENA
Control Minor0.05Control Major0.95Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 31
KARG ID:ASSO0031PubMed ID17608938Year2007Author Name:Anney RJ
Title:Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction:evidence from a prospective population based cohort study of young adults.
Method:denaturing high-performance liquid chromatography Study Designcase-controlAddictive DrugnicotineBehavior:Nicotine Dependence
Gene Name:CHRM5Marker Namers7162140Marker InformationC>TOriginal Report:negative
Ethnic:European CaucasianCase Sample Size76Control Sample Size197
Case Age:14-24Case Male%NAControl Age14-24Control Male%:NA
Case Minor:32Case Major120Case HWEN.A
Control Minor57Control Major337Control HWE:N.A
Case AA:4Case AB24Case BB48
Control AA4Control AB49Control BB:144
Curator:CYLClinical InformationDSM-IV and ICD-10
Allelic Contrast Test 32
KARG ID:ASSO0032PubMed ID17608938Year2007Author Name:Anney RJ
Title:Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction:evidence from a prospective population based cohort study of young adults.
Method:denaturing high-performance liquid chromatography Study Designcase-controlAddictive DrugalcoholBehavior:Alcohol Dependence
Gene Name:CHRM5Marker Namers7162140Marker InformationC>TOriginal Report:negative
Ethnic:European CaucasianCase Sample Size463Control Sample Size81
Case Age:14-24Case Male%NAControl Age14-24Control Male%:NA
Case Minor:171Case Major755Case HWEN.A
Control Minor34Control Major128Control HWE:N.A
Case AA:18Case AB135Case BB310
Control AA3Control AB28Control BB:50
Curator:CYLClinical InformationDSM-IV and ICD-10
Allelic Contrast Test 33
KARG ID:ASSO0033PubMed ID17608938Year2007Author Name:Anney RJ
Title:Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction:evidence from a prospective population based cohort study of young adults.
Method:denaturing high-performance liquid chromatography Study Designcase-controlAddictive DrugcannabisBehavior:Cannabis Dependence
Gene Name:CHRM5Marker Namers7162140Marker InformationC>TOriginal Report:positive
Ethnic:European CaucasianCase Sample Size51Control Sample Size34
Case Age:14-24Case Male%NAControl Age14-24Control Male%:NA
Case Minor:13Case Major89Case HWEN.A
Control Minor17Control Major51Control HWE:N.A
Case AA:2Case AB9Case BB40
Control AA2Control AB13Control BB:19
Curator:CYLClinical InformationDSM-IV and ICD-10
Allelic Contrast Test 34
KARG ID:ASSO0034PubMed ID17106427Year2006Author Name:Malison RT
Title:"Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia"
Method:PCR amplification and restriction digestionStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine-dependent
Gene Name:CLOCKMarker Namers1801260Marker Information3111T>COriginal Report:negative
Ethnic:European AmericanCase Sample Size101Control Sample Size240
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:53Case Major149Case HWE"YES, P=0.93"
Control Minor149Control Major331Control HWE:"YES, P=0.93"
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationNA
Allelic Contrast Test 35
KARG ID:ASSO0035PubMed ID17106427Year2006Author Name:Malison RT
Title:"Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia"
Method:PCR amplification and restriction digestionStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine-dependent
Gene Name:CLOCKMarker Namers1801260Marker Information3111T>COriginal Report:negative
Ethnic:African AmericanCase Sample Size85Control Sample Size33
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:37Case Major133Case HWE"YES, P=0.93"
Control Minor12Control Major54Control HWE:"YES, P=0.93"
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationNA
Allelic Contrast Test 36
KARG ID:ASSO0036PubMed ID17106427Year2006Author Name:Malison RT
Title:"Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia"
Method:PCR amplification and restriction digestionStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine-dependent paranoid/nonparanoid
Gene Name:CLOCKMarker Namers1801260Marker Information3111T>COriginal Report:negative
Ethnic:European AmericanCase Sample Size40Control Sample Size22
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:21Case Major59Case HWE"YES, P=0.93"
Control Minor14Control Major30Control HWE:"YES, P=0.93"
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationNA
Allelic Contrast Test 37
KARG ID:ASSO0037PubMed ID17106427Year2006Author Name:Malison RT
Title:"Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia"
Method:PCR amplification and restriction digestionStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine-dependent paranoid/nonparanoid
Gene Name:CLOCKMarker Namers1801260Marker Information3111T>COriginal Report:negative
Ethnic:African AmericanCase Sample Size32Control Sample Size21
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:13Case Major51Case HWE"YES, P=0.93"
Control Minor9Control Major33Control HWE:"YES, P=0.93"
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationNA
Allelic Contrast Test 38
KARG ID:ASSO0038PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:ABI autosequencerStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker Name(AAT)nMarker Information(AAT)nOriginal Report:positive
Ethnic:European-AmericanCase Sample Size322Control Sample Size169
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:9:5;10:3;11:5;12:137;13:37;14:72;15:58;16:115;17:14;18:2Case MajorNACase HWENA
Control Minor9:5;10:5;11:2;12:126;13:36;14:36;15:67;16:69;17:3;18:1Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 39
KARG ID:ASSO0039PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:ABI autosequencerStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker Name(AAT)nMarker Information(AAT)nOriginal Report:positive
Ethnic:African-AmericanCase Sample Size212Control Sample Size85
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:9:1;10:0;11:19;12:85;13:48;14:20;15:18;16:12;17:1;18:0Case MajorNACase HWENA
Control Minor9:1;10:1;11:24;12:70;13:36;14:24;15:5;16:19;17:0;18:0Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 40
KARG ID:ASSO0040PubMed ID10822338Year2000Author Name:Li T
Title:No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population
Method:ABI 377 sequencer/genotyper (PE Applied Biosystems)Study Designcase-controlAddictive DrugopioidsBehavior:heroin abuse
Gene Name:CNR1Marker Name(AAT)n repeatsMarker Information"(AAT)9,12,13,14,15,16,17,18,19"Original Report:negative
Ethnic:ChineseCase Sample Size375Control Sample Size198
Case Age:27.35+-5.82Case Male%72.30%Control Age28.01+-10.25Control Male%:63.60%
Case Minor:9:77;12:48;13:25;14:109;15:308;16:153;17:29;18:0;19:1Case MajorNACase HWENA
Control Minor9:40;12:21;13:19;14:54;15:160;16:88;17:13;18:1;19:0Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 41
KARG ID:ASSO0041PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker Name-3180T I/DMarker InformationD<Original Report:negative
Ethnic:European-AmericanCase Sample Size135Control Sample Size127
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:13Case Major257Case HWEYES
Control Minor12Control Major242Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 42
KARG ID:ASSO0042PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker Name-3180T I/DMarker InformationD<Original Report:positive
Ethnic:African-AmericanCase Sample Size96Control Sample Size94
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:53Case Major139Case HWEYES
Control Minor71Control Major117Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 43
KARG ID:ASSO0043PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker Name3813G>AMarker InformationAOriginal Report:negative
Ethnic:European-AmericanCase Sample Size84Control Sample Size85
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:12Case Major156Case HWEYES
Control Minor11Control Major159Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 44
KARG ID:ASSO0044PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker Name3813G>AMarker InformationAOriginal Report:negative
Ethnic:African-AmericanCase Sample Size141Control Sample Size100
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:64Case Major218Case HWEYES
Control Minor34Control Major166Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 45
KARG ID:ASSO0045PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11418432Marker InformationC<Original Report:negative
Ethnic:European-AmericanCase Sample Size333Control Sample Size192
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:140Case Major526Case HWEYES
Control Minor82Control Major302Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 46
KARG ID:ASSO0046PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11418432Marker InformationC<Original Report:negative
Ethnic:African-AmericanCase Sample Size235Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:66Case Major404Case HWEYES
Control Minor24Control Major170Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 47
KARG ID:ASSO0047PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11418433Marker InformationG<Original Report:negative
Ethnic:European-AmericanCase Sample Size348Control Sample Size198
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:220Case Major476Case HWEYES
Control Minor129Control Major267Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 48
KARG ID:ASSO0048PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11418433Marker InformationG<Original Report:negative
Ethnic:African-AmericanCase Sample Size216Control Sample Size92
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:134Case Major298Case HWEYES
Control Minor67Control Major117Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 49
KARG ID:ASSO0049PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11418434Marker InformationG<Original Report:negative
Ethnic:European-AmericanCase Sample Size330Control Sample Size179
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:148Case Major512Case HWEYES
Control Minor79Control Major279Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 50
KARG ID:ASSO0050PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11418434Marker InformationG<Original Report:negative
Ethnic:African-AmericanCase Sample Size234Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:67Case Major401Case HWEYES
Control Minor23Control Major171Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 51
KARG ID:ASSO0051PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11600616Marker InformationG<Original Report:positive
Ethnic:European-AmericanCase Sample Size336Control Sample Size190
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:133Case Major539Case HWEYES
Control Minor57Control Major323Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 52
KARG ID:ASSO0052PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV11600616Marker InformationG<Original Report:positive
Ethnic:African-AmericanCase Sample Size230Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:175Case Major285Case HWEYES
Control Minor60Control Major134Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 53
KARG ID:ASSO0053PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV15841551Marker InformationC<Original Report:positive
Ethnic:European-AmericanCase Sample Size354Control Sample Size197
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:436Case Major272Case HWEYES
Control Minor220Control Major174Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 54
KARG ID:ASSO0054PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV15841551Marker InformationC<Original Report:negative
Ethnic:African-AmericanCase Sample Size234Control Sample Size92
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:172Case Major296Case HWEYES
Control Minor70Control Major114Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 55
KARG ID:ASSO0055PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV16178942Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size86Control Sample Size63
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:1Case Major171Case HWEYES
Control Minor0Control Major126Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 56
KARG ID:ASSO0056PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV16178942Marker InformationA<Original Report:negative
Ethnic:African-AmericanCase Sample Size90Control Sample Size92
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:0Case Major180Case HWEYES
Control Minor1Control Major183Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 57
KARG ID:ASSO0057PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV1652582Marker InformationG<Original Report:negative
Ethnic:European-AmericanCase Sample Size360Control Sample Size210
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:222Case Major498Case HWEYES
Control Minor120Control Major300Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 58
KARG ID:ASSO0058PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV1652582Marker InformationG<Original Report:negative
Ethnic:African-AmericanCase Sample Size237Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:136Case Major338Case HWEYES
Control Minor64Control Major130Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 59
KARG ID:ASSO0059PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV1652584Marker InformationT<Original Report:positive
Ethnic:European-AmericanCase Sample Size351Control Sample Size192
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:331Case Major371Case HWEYES
Control Minor145Control Major239Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 60
KARG ID:ASSO0060PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV1652584Marker InformationT<Original Report:positive
Ethnic:African-AmericanCase Sample Size224Control Sample Size87
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:246Case Major202Case HWEYES
Control Minor88Control Major86Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 61
KARG ID:ASSO0061PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV1652590Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size101Control Sample Size85
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:61Case Major141Case HWEYES
Control Minor56Control Major114Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 62
KARG ID:ASSO0062PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV1652590Marker InformationA<Original Report:negative
Ethnic:African-AmericanCase Sample Size145Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:45Case Major245Case HWEYES
Control Minor21Control Major173Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 63
KARG ID:ASSO0063PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV27392043Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size86Control Sample Size124
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:48Case Major124Case HWEYES
Control Minor73Control Major175Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 64
KARG ID:ASSO0064PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV27392043Marker InformationA<Original Report:negative
Ethnic:African-AmericanCase Sample Size96Control Sample Size92
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:62Case Major130Case HWEYES
Control Minor61Control Major123Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 65
KARG ID:ASSO0065PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV8943758Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size351Control Sample Size190
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:129Case Major573Case HWEYES
Control Minor57Control Major323Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 66
KARG ID:ASSO0066PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV8943758Marker InformationA<Original Report:positive
Ethnic:African-AmericanCase Sample Size235Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:167Case Major303Case HWEYES
Control Minor58Control Major136Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 67
KARG ID:ASSO0067PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV8943766Marker InformationNAOriginal Report:negative
Ethnic:European-AmericanCase Sample Size355Control Sample Size192
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:170Case Major540Case HWEYES
Control Minor107Control Major277Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 68
KARG ID:ASSO0068PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV8943766Marker InformationNAOriginal Report:negative
Ethnic:African-AmericanCase Sample Size237Control Sample Size97
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:35Case Major439Case HWEYES
Control Minor14Control Major180Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 69
KARG ID:ASSO0069PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV8943804Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size113Control Sample Size162
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:49Case Major177Case HWEYES
Control Minor64Control Major260Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 70
KARG ID:ASSO0070PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV8943804Marker InformationA<Original Report:negative
Ethnic:African-AmericanCase Sample Size142Control Sample Size99
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:32Case Major252Case HWEYES
Control Minor17Control Major181Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 71
KARG ID:ASSO0071PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NameHCV9046296Marker InformationG<Original Report:negative
Ethnic:European-AmericanCase Sample Size87Control Sample Size123
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:15Case Major159Case HWEYES
Control Minor22Control Major224Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 72
KARG ID:ASSO0072PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NameHCV9046296Marker InformationG<Original Report:negative
Ethnic:African-AmericanCase Sample Size96Control Sample Size90
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:49Case Major143Case HWEYES
Control Minor43Control Major137Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 73
KARG ID:ASSO0073PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NameHCV9046297Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size87Control Sample Size131
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:15Case Major159Case HWEYES
Control Minor19Control Major243Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 74
KARG ID:ASSO0074PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NameHCV9046297Marker InformationA<Original Report:negative
Ethnic:African-AmericanCase Sample Size95Control Sample Size90
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:42Case Major148Case HWEYES
Control Minor43Control Major137Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 75
KARG ID:ASSO0075PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NameHCV9662507Marker InformationA<Original Report:negative
Ethnic:European-AmericanCase Sample Size143Control Sample Size122
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:86Case Major200Case HWEYES
Control Minor77Control Major167Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 76
KARG ID:ASSO0076PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NameHCV9662507Marker InformationA<Original Report:negative
Ethnic:African-AmericanCase Sample Size149Control Sample Size91
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:136Case Major162Case HWEYES
Control Minor78Control Major104Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 77
KARG ID:ASSO0077PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV9863392Marker InformationG<Original Report:negative
Ethnic:European-AmericanCase Sample Size83Control Sample Size94
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:11Case Major155Case HWEYES
Control Minor18Control Major170Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 78
KARG ID:ASSO0078PubMed ID15289816Year2004Author Name:Zhang PW
Title:"Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse"
Method:TaqMan 5' nuclease assaysStudy Designcase-controlAddictive DrugmixedBehavior:polysubstance abusers
Gene Name:CNR1Marker NamehCV9863392Marker InformationG<Original Report:negative
Ethnic:African-AmericanCase Sample Size79Control Sample Size90
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:1Case Major157Case HWEYES
Control Minor1Control Major179Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSMIII-R and DSM IV criteria
Allelic Contrast Test 79
KARG ID:ASSO0079PubMed ID9106242Year1997Author Name:Comings DE
Title:Cannabinoid receptor gene (CNR1): association with i.v. drug use
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine
Gene Name:CNR1Marker Name(AAT)nMarker Information"% >=5/>=5, '<5' < '>=5'"Original Report:positive
Ethnic:non-Hispanic CaucasiansCase Sample Size49Control Sample Size138
Case Age:39.7+-7Case Male%100%Control Age38.4+-12.6Control Male%:39.50%
Case Minor:20Case Major29Case HWENA
Control Minor50Control Major88Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDiagnostic Interview Schedule (DIS) + Addiction Severity Index (ASI)
Allelic Contrast Test 80
KARG ID:ASSO0080PubMed ID9106242Year1997Author Name:Comings DE
Title:Cannabinoid receptor gene (CNR1): association with i.v. drug use
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugAmphetaminesBehavior:Amphetamines
Gene Name:CNR1Marker Name(AAT)nMarker Information"% >=5/>=5, '<5' < '>=5'"Original Report:positive
Ethnic:non-Hispanic CaucasiansCase Sample Size44Control Sample Size129
Case Age:39.7+-7Case Male%100%Control Age38.4+-12.6Control Male%:39.50%
Case Minor:22Case Major22Case HWENA
Control Minor46Control Major79Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDiagnostic Interview Schedule (DIS) + Addiction Severity Index (ASI)
Allelic Contrast Test 81
KARG ID:ASSO0081PubMed ID9106242Year1997Author Name:Comings DE
Title:Cannabinoid receptor gene (CNR1): association with i.v. drug use
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugHeroinBehavior:Heroin
Gene Name:CNR1Marker Name(AAT)nMarker Information"% >=5/>=5, '<5' < '>=5'"Original Report:positive
Ethnic:non-Hispanic CaucasiansCase Sample Size8Control Sample Size177
Case Age:39.7+-7Case Male%100%Control Age38.4+-12.6Control Male%:39.50%
Case Minor:3Case Major5Case HWENA
Control Minor66Control Major111Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDiagnostic Interview Schedule (DIS) + Addiction Severity Index (ASI)
Allelic Contrast Test 82
KARG ID:ASSO0082PubMed ID16314880Year2006Author Name:Ballon N
Title:(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population
Method:LICOR 4000?L sequencerStudy Designcase-controlAddictive DrugcocaineBehavior:non-schizophrenic cocaine dependents
Gene Name:CNR1Marker Name(AAT)nMarker InformationNAOriginal Report:positive
Ethnic:African CaribbeanCase Sample Size97Control Sample Size88
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:9:0;11:6;12:50;13:51;14:29;15:20;16;22;17:15;18:2Case MajorNACase HWENA
Control Minor9:0;11:1;12:10;13:66;14:38;15:16;16;20;17:22;18:3Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV criteria of smoked-cocaine abuse
Allelic Contrast Test 83
KARG ID:ASSO0083PubMed ID16314880Year2006Author Name:Ballon N
Title:(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population
Method:LICOR 4000?L sequencerStudy Designcase-controlAddictive DrugcocaineBehavior:schizophrenic cocaine dependents
Gene Name:CNR1Marker Name(AAT)nMarker InformationNAOriginal Report:positive
Ethnic:African CaribbeanCase Sample Size45Control Sample Size88
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:9:1;11:5;12:24;13:21;14:15;15:6;16;12;17:6;18:0Case MajorNACase HWENA
Control Minor9:0;11:1;12:10;13:66;14:38;15:16;16;20;17:22;18:3Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV criteria of smoked-cocaine abuse
Allelic Contrast Test 84
KARG ID:ASSO0084PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive Drugcocaine dependanceBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:Nagative
Ethnic:CaucasianCase Sample Size340Control Sample Size388
Case Age:36.8 (7.9)Case Male%69%Control Age28.3 (8.4)Control Male%:34%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 85
KARG ID:ASSO0085PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive Drugopioid depBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:nagative
Ethnic:CaucasianCase Sample Size176Control Sample Size388
Case Age:36.3 (8.9)Case Male%62%Control Age28.3 (8.4)Control Male%:34%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 86
KARG ID:ASSO0086PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive DrugCannabis depBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:Nagative
Ethnic:CaucasianCase Sample Size200Control Sample Size388
Case Age:35.1 (7.7)Case Male%70%Control Age28.3 (8.4)Control Male%:34%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 87
KARG ID:ASSO0087PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive DrugPolysubstance depBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:nagative
Ethnic:CaucasianCase Sample Size350Control Sample Size388
Case Age:36.6 (8.0)Case Male%67%Control Age28.3 (8.4)Control Male%:34%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 88
KARG ID:ASSO0088PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive DrugAlcohol dep onlyBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:positive
Ethnic:CaucasianCase Sample Size214Control Sample Size388
Case Age:43.8 (9.6)Case Male%77%Control Age28.3 (8.4)Control Male%:34%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 89
KARG ID:ASSO0089PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive Drugcocaine dependanceBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:nagative
Ethnic:African-AmericanCase Sample Size268Control Sample Size84
Case Age:39 (7.6)Case Male%65%Control Age31.9 (10.0)Control Male%:35%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 90
KARG ID:ASSO0090PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive Drugopioid depBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:Nagative
Ethnic:African-AmericanCase Sample Size101Control Sample Size84
Case Age:41 (8.4)Case Male%61%Control Age31.9 (10.0)Control Male%:35%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 91
KARG ID:ASSO0091PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive DrugCannabis depBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:nagative
Ethnic:African-AmericanCase Sample Size92Control Sample Size84
Case Age:38.5 (7.7)Case Male%65%Control Age31.9 (10.0)Control Male%:35%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 92
KARG ID:ASSO0092PubMed ID16741937Year2006Author Name:Herman AI
Title:Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
Method:"TaqMan,7500Sequencing"Study Designcase-controlAddictive DrugPolysubstance depBehavior:NA
Gene Name:CNR1Marker Namers6928499 (G/C);rs806379 (A/T);rs1535255 (T/G);rs2023239 (T/C)Marker InformationNAOriginal Report:nagative
Ethnic:African-AmericanCase Sample Size205Control Sample Size84
Case Age:39 (7.7)Case Male%63%Control Age31.9 (10.0)Control Male%:35%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 93
KARG ID:ASSO0093PubMed ID16917946Year2006Author Name:Hopfer CJ
Title:Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents
Method:TaqmanStudy Designcase-controlAddictive DrugCannabis DependenceBehavior:NA
Gene Name:CNR1Marker Namers806380Marker Information"A/G,located in intro2"Original Report:positiveP<0.02
Ethnic:"all are%,case/control:Caucasian67.9%/72.9%;Hispanic19.3/18.7;African-American6.4/5.1;others6.4/3.3"Case Sample Size327Control Sample Size214
Case Age:18.1+14Case Male%74.30%Control Age18.2+1.5Control Male%:49.50%
Case Minor:"MAF0.34, G is protective"Case MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 94
KARG ID:ASSO0094PubMed ID15274053Year2004Author Name:Li T
Title:Association analysis of the DRD4 and COMT genes in methamphetamine abuse
Method:Amplification Refractory Mutation System (ARMS) assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine-induced psychosis
Gene Name:COMTMarker Namers4680Marker InformationVal>MetOriginal Report:positive
Ethnic:ChineseCase Sample Size143Control Sample Size390
Case Age:27.2+-7.0Case Male%63.20%Control Age34.4+-10.0Control Male%:57%
Case Minor:80Case Major206Case HWENA
Control Minor246Control Major534Control HWE:NA
Case AA:11Case AB58Case BB74
Control AA37Control AB172Control BB:181
Curator:CYLClinical Information"DSM-IV criteria following an interview with the Chinese version of Diagnostic Interview for Genetic Studies [DIGS-C; Chen et al., [2004]]"
Allelic Contrast Test 95
KARG ID:ASSO0095PubMed ID15274053Year2004Author Name:Li T
Title:Association analysis of the DRD4 and COMT genes in methamphetamine abuse
Method:Amplification Refractory Mutation System (ARMS) assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users with no psychosis
Gene Name:COMTMarker Namers4680Marker InformationVal>MetOriginal Report:positive
Ethnic:ChineseCase Sample Size256Control Sample Size390
Case Age:27.2+-7.0Case Male%63.20%Control Age34.4+-10.0Control Male%:57%
Case Minor:128Case Major384Case HWENA
Control Minor246Control Major534Control HWE:NA
Case AA:21Case AB86Case BB149
Control AA37Control AB172Control BB:181
Curator:CYLClinical Information"DSM-IV criteria following an interview with the Chinese version of Diagnostic Interview for Genetic Studies [DIGS-C; Chen et al., [2004]]"
Allelic Contrast Test 96
KARG ID:ASSO0096PubMed ID18184800Year2008Author Name:Nikoshkov A
Title:Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression
Method:capillary electrophoresis DNA analyzer ABI3730Study Designcase-controlAddictive DrugopioidsBehavior:heroin abuse
Gene Name:COMTMarker Namers4680Marker InformationMet>ValOriginal Report:negative
Ethnic:CaucasianCase Sample Size32Control Sample Size17
Case Age:the same with 16682632Case Male%NAControl AgeNAControl Male%:NA
Case Minor:31Case Major33Case HWEP>0.5
Control Minor13Control Major21Control HWE:P>0.5
Case AA:7Case AB17Case BB8
Control AA2Control AB9Control BB:6
Curator:CYLClinical Informationmedical records and police and/or family reports
Allelic Contrast Test 97
KARG ID:ASSO0097PubMed ID11927842Year2002Author Name:David SP
Title:"No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation"
Method:"PCR-SSP,PCR-sequence-speci?c primers"Study Designcase-controlAddictive DrugSmokerBehavior:NA
Gene Name:COMTMarker NameNAMarker Information1947A.GOriginal Report:nagative
Ethnic:"UK,Caucasian"Case Sample Size266Control Sample Size265
Case Age:51.3 (8.8)Case Male%138 (49.3)Control Age51.3 (8.8)Control Male%:138 (49.3)
Case Minor:0.46Case Major0.54Case HWENA
Control Minor0.43Control Major0.57Control HWE:NA
Case AA:59 (22.2) Case AB127 (47.7) Case BB80 (30.1)
Control AA54 (20.4) Control AB121 (45.7) Control BB:90 (34.0)
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 98
KARG ID:ASSO0098PubMed ID16550213Year2006Author Name:Treutlein J
Title:Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
Method:direct sequencing with an ABI Prism 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugalcoholBehavior:lifetime binge drinking
Gene Name:CRHR1Marker Namers1876831Marker InformationC>TOriginal Report:positive
Ethnic:Central European descendentCase Sample Size91Control Sample Size191
Case Age:NACase Male%48.30%Control Age41.58Control Male%:79.20%
Case Minor:22Case Major160Case HWEOK
Control Minor90Control Major292Control HWE:OK
Case AA:1Case AB20Case BB70
Control AA12Control AB66Control BB:113
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 99
KARG ID:ASSO0099PubMed ID16550213Year2006Author Name:Treutlein J
Title:Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
Method:direct sequencing with an ABI Prism 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugalcoholBehavior:lifetime prevalence drunkenness
Gene Name:CRHR1Marker Namers1876831Marker InformationC>TOriginal Report:positive
Ethnic:Central European descendentCase Sample Size114Control Sample Size168
Case Age:NACase Male%48.30%Control Age41.58Control Male%:79.20%
Case Minor:32Case Major196Case HWEOK
Control Minor80Control Major256Control HWE:OK
Case AA:3Case AB26Case BB85
Control AA10Control AB60Control BB:98
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 100
KARG ID:ASSO0100PubMed ID16550213Year2006Author Name:Treutlein J
Title:Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
Method:direct sequencing with an ABI Prism 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugalcoholBehavior:lifetime binge drinking
Gene Name:CRHR1Marker Namers242938Marker InformationG>AOriginal Report:positive
Ethnic:Central European descendentCase Sample Size93Control Sample Size192
Case Age:NACase Male%48.30%Control Age41.58Control Male%:79.20%
Case Minor:24Case Major162Case HWEOK
Control Minor25Control Major359Control HWE:OK
Case AA:2Case AB20Case BB71
Control AA1Control AB23Control BB:168
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 101
KARG ID:ASSO0101PubMed ID16550213Year2006Author Name:Treutlein J
Title:Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
Method:direct sequencing with an ABI Prism 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugalcoholBehavior:lifetime prevalence drunkenness
Gene Name:CRHR1Marker Namers242938Marker InformationG>AOriginal Report:positive
Ethnic:Central European descendentCase Sample Size116Control Sample Size169
Case Age:NACase Male%48.30%Control Age41.58Control Male%:79.20%
Case Minor:29Case Major203Case HWEOK
Control Minor20Control Major318Control HWE:OK
Case AA:2Case AB25Case BB89
Control AA1Control AB18Control BB:150
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 102
KARG ID:ASSO0102PubMed ID11236836Year2001Author Name:Pastorelli R
Title:Genetic determinants of alcohol addiction and metabolism: a survey in Italy
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent subjects
Gene Name:CYP2E1Marker NameDra IMarker Informationd>COriginal Report:negative
Ethnic:white ItaliansCase Sample Size60Control Sample Size64
Case Age:46.4 years+-10.8Case Male%75%Control Age45+-9.51Control Male%:79.70%
Case Minor:8Case Major112Case HWENA
Control Minor13Control Major115Control HWE:NA
Case AA:1Case AB6Case BB53
Control AA1Control AB11Control BB:52
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 103
KARG ID:ASSO0103PubMed ID11236836Year2001Author Name:Pastorelli R
Title:Genetic determinants of alcohol addiction and metabolism: a survey in Italy
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent subjects
Gene Name:CYP2E1Marker NameRsa I Marker Informationc1>c2Original Report:negative
Ethnic:white ItaliansCase Sample Size60Control Sample Size64
Case Age:46.4 years+-10.8Case Male%75%Control Age45+-9.51Control Male%:79.70%
Case Minor:3Case Major117Case HWENA
Control Minor6Control Major122Control HWE:NA
Case AA:0Case AB3Case BB57
Control AA0Control AB6Control BB:58
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 104
KARG ID:ASSO0104PubMed ID9152990Year1997Author Name:Kotler M
Title:Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugopioidsBehavior:opioid-dependent patients
Gene Name:DRD4Marker Nameexon III polymorphismMarker Information2/3/4/5/6/7/8Original Report:positive (7 repeat )
Ethnic:Sephardic Jews/Israeli ArabsCase Sample Size141Control Sample Size110
Case Age:32.4+-0.54Case Male%100%Control Age45.8+-2.28Control Male%:100%
Case Minor:2:27;3:2;4:197;5:6;6:0;7:44;8:3Case MajorNACase HWENA
Control Minor2:33;3:3;4:157;5:8;6:1;7:14;8:2Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV criteria for opioid use disorders
Allelic Contrast Test 105
KARG ID:ASSO0105PubMed ID12658362Year2003Author Name:Hong CJ
Title:Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males
Method:GelStudy Designcase-controlAddictive Drugmethamphetamine abuseBehavior:NA
Gene Name:"DAT 3'VNTR,40-base pair (bp)"Marker NameNAMarker InformationNAOriginal Report:nagative
Ethnic:Han(taiwan)Case Sample Size103Control Sample Size112
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:9R/8.9%Case Major10R/91.9%Case HWENA
Control Minor7.80%Control Major92.20%Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 106
KARG ID:ASSO0106PubMed ID18173840Year2008Author Name:Guindalini C
Title:Dopamine-beta hydroxylase polymorphism and cocaine addiction
Method:amplifluorStudy Designcase-controlAddictive DrugcocaineBehavior:susceptibility of cocaine addiction
Gene Name:DBHMarker Namers1611115Marker InformationC>TOriginal Report:negative
Ethnic:"Sao Paulo,Brazil "Case Sample Size689Control Sample Size832
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:308Case Major1070Case HWEYES
Control Minor396Control Major1268Control HWE:YES
Case AA:40Case AB228Case BB421
Control AA51Control AB294Control BB:487
Curator:CYLClinical InformationNA
Allelic Contrast Test 107
KARG ID:ASSO0107PubMed ID16594948Year2006Author Name:Liu HC
Title:Association between dopamine receptor D1 A-48G polymorphism and methamphetamine abuse
Method:PCR-RFLPStudy Designcase-controlAddictive DrugMethamphetamine abusers with psychosisBehavior:NA
Gene Name:DRD1Marker NameA-48GMarker InformationNAOriginal Report:Nagative
Ethnic:Han(taiwan)Case Sample Size135Control Sample Size425
Case Age:27.0+-7.0Case Male%72.60%Control Age34.5+-9.5bControl Male%:57.60%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 108
KARG ID:ASSO0108PubMed ID16594948Year2006Author Name:Liu HC
Title:Association between dopamine receptor D1 A-48G polymorphism and methamphetamine abuse
Method:PCR-RFLPStudy Designcase-controlAddictive DrugMethamphetamine abusers without psychosisBehavior:NA
Gene Name:DRD1Marker NameA-48GMarker InformationNAOriginal Report:Nagative
Ethnic:Han(taiwan)Case Sample Size228Control Sample Size425
Case Age:27.2+-6.7Case Male%56.60%Control Age34.5+-9.5bControl Male%:57.60%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R or DSM-IV (SCID)
Allelic Contrast Test 109
KARG ID:ASSO0109PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name?20236 C>TMarker InformationC>TOriginal Report:negative
Ethnic:ChineseCase Sample Size469Control Sample Size310
Case Age:27.3+-5.80Case Male%NAControl Age28.0+-10.0Control Male%:NA
Case Minor:446Case Major492Case HWEOK
Control Minor285Control Major335Control HWE:OK
Case AA:89Case AB268Case BB112
Control AA58Control AB169Control BB:83
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 110
KARG ID:ASSO0110PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name?exon 8 22640 C>GMarker InformationC>GOriginal Report:negative
Ethnic:GermanCase Sample Size459Control Sample Size192
Case Age:30.2+-6.8Case Male%NAControl Age31.8+-7.0Control Male%:NA
Case Minor:631Case Major287Case HWEOK
Control Minor265Control Major119Control HWE:OK
Case AA:218Case AB195Case BB46
Control AA94Control AB77Control BB:21
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 111
KARG ID:ASSO0111PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name?intron 4 T>CMarker InformationT>COriginal Report:negative
Ethnic:GermanCase Sample Size456Control Sample Size189
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:545Case Major367Case HWEOK
Control Minor227Control Major151Control HWE:OK
Case AA:169Case AB207Case BB80
Control AA65Control AB97Control BB:27
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 112
KARG ID:ASSO0112PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name?TaqIB A>GMarker InformationA>GOriginal Report:positive
Ethnic:ChineseCase Sample Size466Control Sample Size306
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:447Case Major485Case HWEOK
Control Minor359Control Major253Control HWE:OK
Case AA:104Case AB239Case BB123
Control AA102Control AB155Control BB:49
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 113
KARG ID:ASSO0113PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name?TaqIB A>GMarker InformationA>GOriginal Report:negative
Ethnic:GermanCase Sample Size459Control Sample Size191
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:769Case Major149Case HWEOK
Control Minor317Control Major65Control HWE:OK
Case AA:324Case AB121Case BB14
Control AA130Control AB57Control BB:4
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 114
KARG ID:ASSO0114PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name?TaqID G>AMarker InformationG>AOriginal Report:negative
Ethnic:GermanCase Sample Size463Control Sample Size193
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:552Case Major374Case HWEOK
Control Minor231Control Major155Control HWE:OK
Case AA:171Case AB210Case BB82
Control AA66Control AB99Control BB:28
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 115
KARG ID:ASSO0115PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name-141ins/delCMarker Informationins>delOriginal Report:positive
Ethnic:ChineseCase Sample Size475Control Sample Size309
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:112Case Major838Case HWEOK
Control Minor51Control Major567Control HWE:OK
Case AA:9Case AB94Case BB372
Control AA1Control AB49Control BB:259
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 116
KARG ID:ASSO0116PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name-141ins/delCMarker Informationins>delOriginal Report:negative
Ethnic:GermanCase Sample Size471Control Sample Size191
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:98Case Major844Case HWEOK
Control Minor41Control Major341Control HWE:OK
Case AA:5Case AB88Case BB378
Control AA2Control AB37Control BB:152
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 117
KARG ID:ASSO0117PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name20236 C>TMarker InformationC>TOriginal Report:negative
Ethnic:GermanCase Sample Size186Control Sample Size462
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:115Case Major257Case HWEOK
Control Minor290Control Major634Control HWE:OK
Case AA:20Case AB75Case BB91
Control AA46Control AB198Control BB:218
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 118
KARG ID:ASSO0118PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name-241 A>GMarker InformationA>GOriginal Report:positive
Ethnic:ChineseCase Sample Size459Control Sample Size302
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:192Case Major726Case HWEOK
Control Minor107Control Major497Control HWE:OK
Case AA:18Case AB156Case BB285
Control AA15Control AB77Control BB:210
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 119
KARG ID:ASSO0119PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name-241 A>GMarker InformationA>GOriginal Report:negative
Ethnic:GermanCase Sample Size463Control Sample Size190
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:58Case Major868Case HWEOK
Control Minor23Control Major357Control HWE:OK
Case AA:4Case AB50Case BB409
Control AA0Control AB23Control BB:167
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 120
KARG ID:ASSO0120PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name311 Ser>CysMarker InformationSer>CysOriginal Report:negative
Ethnic:ChineseCase Sample Size482Control Sample Size283
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:30Case Major934Case HWEOK
Control Minor24Control Major542Control HWE:OK
Case AA:1Case AB28Case BB453
Control AA0Control AB24Control BB:259
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 121
KARG ID:ASSO0121PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Name311 Ser>CysMarker InformationSer>CysOriginal Report:negative
Ethnic:GermanCase Sample Size457Control Sample Size192
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:20Case Major894Case HWEOK
Control Minor5Control Major379Control HWE:OK
Case AA:0Case AB20Case BB437
Control AA0Control AB5Control BB:187
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 122
KARG ID:ASSO0122PubMed ID12811641Year2003Author Name:Wiesbeck GA
Title:Dopamine D2 (DAD2) and dopamine D3 (DAD3) receptor gene polymorphisms and treatment outcome in alcohol dependence
Method:RFLP assayStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol abstainers/relapsers
Gene Name:DRD2Marker Name5 promoter region -141C InsDelMarker InformationD1>D2Original Report:negative
Ethnic:GermanCase Sample Size56Control Sample Size51
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:Combine: 10Case ABNACase BB46
Control AACombine: 9Control ABNAControl BB:42
Curator:CYLClinical Information"ICD-10 criteria using a German version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA; Buchholz et al., 1994)."
Allelic Contrast Test 123
KARG ID:ASSO0123PubMed ID8907305Year1996Author Name:Finckh U
Title:Allele-specific PCR for simultaneous amplification of both alleles of a deletion polymorphism in intron 6 of the human dopamine 2 receptor gene (DRD2)
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholics
Gene Name:DRD2Marker Namedeletion polymorphism in intron 6Marker InformationIns>DelOriginal Report:negative
Ethnic:?CaucasiansCase Sample Size270Control Sample Size95
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:86Case Major454Case HWENA
Control Minor29Control Major95Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationNA
Allelic Contrast Test 124
KARG ID:ASSO0124PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Nameexon 8 22640 C>GMarker InformationC>GOriginal Report:negative
Ethnic:ChineseCase Sample Size474Control Sample Size310
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:416Case Major532Case HWEOK
Control Minor286Control Major334Control HWE:OK
Case AA:79Case AB258Case BB137
Control AA59Control AB168Control BB:83
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 125
KARG ID:ASSO0125PubMed ID9259374Year1999Author Name:Goldman D
Title:"Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians"
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:DRD2Marker NameIntron -2 STRMarker Information13/14/15/16Original Report:negative
Ethnic:Southwestern American IndiansCase Sample Size276Control Sample Size161
Case Age:NACase Male%42.70%Control AgeNAControl Male%:42.70%
Case Minor:13:66;14:149;15:22;16:315Case MajorNACase HWENA
Control Minor13:32;14:84;15:16;16:190Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 126
KARG ID:ASSO0126PubMed ID9259374Year1999Author Name:Goldman D
Title:"Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance abuse
Gene Name:DRD2Marker NameIntron -2 STRMarker Information13/14/15/16Original Report:negative
Ethnic:Southwestern American IndiansCase Sample Size170Control Sample Size267
Case Age:NACase Male%42.70%Control AgeNAControl Male%:42.70%
Case Minor:13:37;14:99;15:14;16:190Case MajorNACase HWENA
Control Minor13:59;14:85;15:17;16:200Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 127
KARG ID:ASSO0127PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Nameintron 4 T>CMarker InformationT>COriginal Report:positive
Ethnic:ChineseCase Sample Size471Control Sample Size304
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:42Case Major900Case HWEOK
Control Minor48Control Major560Control HWE:OK
Case AA:1Case AB40Case BB430
Control AA2Control AB44Control BB:258
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 128
KARG ID:ASSO0128PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Nameintron 6 ins/del GMarker InformationinsG>DelGOriginal Report:negative
Ethnic:ChineseCase Sample Size474Control Sample Size311
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:393Case Major555Case HWEOK
Control Minor247Control Major375Control HWE:OK
Case AA:70Case AB253Case BB151
Control AA47Control AB153Control BB:111
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 129
KARG ID:ASSO0129PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker Nameintron 6 ins/del GMarker InformationinsG>DelGOriginal Report:negative
Ethnic:GermanCase Sample Size463Control Sample Size190
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:145Case Major781Case HWEOK
Control Minor71Control Major309Control HWE:OK
Case AA:12Case AB121Case BB330
Control AA7Control AB57Control BB:126
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 130
KARG ID:ASSO0130PubMed ID18307984Year2008Author Name:Joe KH
Title:Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients
Method:TaqMan GenotypeStudy Designcase-controlAddictive DrugalcoholBehavior:Alcohol-dependent patients
Gene Name:DRD2Marker NameNAMarker Information-32768 ins>delOriginal Report:negtive
Ethnic:AsianCase Sample Size535Control Sample Size273
Case Age:46.89(20-73)Case Male%NAControl Age20(20-20)Control Male%:100%
Case Minor:184Case Major690Case HWE0.84
Control Minor88Control Major370Control HWE:0.227
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 131
KARG ID:ASSO0131PubMed ID9129710Year1997Author Name:Chen WJ
Title:Dopamine D2 receptor gene and alcoholism among four aboriginal groups and Han in Taiwan
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:severe alcoholics
Gene Name:DRD2Marker NameNcoIMarker InformationN1>N2Original Report:negative
Ethnic:ChineseCase Sample Size203Control Sample Size212
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:224Case Major182Case HWENA
Control Minor257Control Major167Control HWE:NA
Case AA:54Case AB116Case BB33
Control AA79Control AB99Control BB:34
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 132
KARG ID:ASSO0132PubMed ID18307984Year2008Author Name:Joe KH
Title:Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients
Method:TaqMan GenotypeStudy Designcase-controlAddictive DrugalcoholBehavior:Alcohol-dependent patients
Gene Name:DRD2Marker Namers1799978Marker InformationA>GOriginal Report:negtive
Ethnic:AsianCase Sample Size535Control Sample Size273
Case Age:46.89(20-73)Case Male%NAControl Age20(20-20)Control Male%:100%
Case Minor:146Case Major766Case HWE0.939
Control Minor84Control Major378Control HWE:0.974
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 133
KARG ID:ASSO0133PubMed ID18307984Year2008Author Name:Joe KH
Title:Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients
Method:TaqMan GenotypeStudy Designcase-controlAddictive DrugalcoholBehavior:Alcohol-dependent patients
Gene Name:DRD2Marker Namers1800497Marker InformationC>TOriginal Report:negtive
Ethnic:AsianCase Sample Size535Control Sample Size273
Case Age:46.89(20-73)Case Male%NAControl Age20(20-20)Control Male%:100%
Case Minor:424Case Major210Case HWE0.063
Control Minor218Control Major110Control HWE:0.792
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 134
KARG ID:ASSO0134PubMed ID18307984Year2008Author Name:Joe KH
Title:Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients
Method:TaqMan GenotypeStudy Designcase-controlAddictive DrugalcoholBehavior:Alcohol-dependent patients
Gene Name:DRD2Marker Namers1801028Marker InformationC>GOriginal Report:negtive
Ethnic:AsianCase Sample Size535Control Sample Size273
Case Age:46.89(20-73)Case Male%NAControl Age20(20-20)Control Male%:100%
Case Minor:34Case Major990Case HWE0.734
Control Minor16Control Major514Control HWE:0.896
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 135
KARG ID:ASSO0135PubMed ID18307984Year2008Author Name:Joe KH
Title:Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients
Method:TaqMan GenotypeStudy Designcase-controlAddictive DrugalcoholBehavior:Alcohol-dependent patients
Gene Name:DRD2Marker Namers6277Marker InformationC>TOriginal Report:negtive
Ethnic:AsianCase Sample Size535Control Sample Size273
Case Age:46.89(20-73)Case Male%NAControl Age20(20-20)Control Male%:100%
Case Minor:62Case Major934Case HWE0.99
Control Minor28Control Major490Control HWE:0.057
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 136
KARG ID:ASSO0136PubMed ID9259374Year1999Author Name:Goldman D
Title:"Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians"
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:DRD2Marker NameSer311CysMarker InformationSer>CysOriginal Report:negative
Ethnic:Southwestern American IndiansCase Sample Size276Control Sample Size161
Case Age:NACase Male%42.70%Control AgeNAControl Male%:42.70%
Case Minor:91.908Case Major460.092Case HWENA
Control Minor48.944Control Major273.056Control HWE:NA
Case AA:9.936Case AB72.036Case BB194.028
Control AA4.991Control AB38.962Control BB:117.047
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 137
KARG ID:ASSO0137PubMed ID9259374Year1999Author Name:Goldman D
Title:"Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance abuse
Gene Name:DRD2Marker NameSer311CysMarker InformationSer>CysOriginal Report:negative
Ethnic:Southwestern American IndiansCase Sample Size170Control Sample Size267
Case Age:NACase Male%42.70%Control AgeNAControl Male%:42.70%
Case Minor:57.97Case Major282.03Case HWENA
Control Minor82.77Control Major451.23Control HWE:NA
Case AA:9.01Case AB39.95Case BB121.04
Control AA5.874Control AB71.022Control BB:190.104
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 138
KARG ID:ASSO0138PubMed ID17671965Year2007Author Name:Ballon N
Title:"Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?"
Method:"amplifications used a PTC-100 thermocycler (MJ Research Inc.) and thermostable Taq Polymerase (AmpliTaq, Perkin Elmer Cetus). "Study Designcase-controlAddictive DrugcocaineBehavior:"smoked-cocaine dependents, 95 cannabis abusers and 77 alcohol abusers"
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1; TaqI repeat fragment length polymorphismOriginal Report:negative
Ethnic:African-CaribbeanCase Sample Size97Control Sample Size88
Case Age:35.8+-6.6Case Male%100%Control Age39.5+-10.2Control Male%:100%
Case Minor:60Case Major134Case HWEYES
Control Minor47Control Major129Control HWE:YES
Case AA:6Case AB48Case BB43
Control AA5Control AB37Control BB:46
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 139
KARG ID:ASSO0139PubMed ID18058350Year2007Author Name:Radwan GN
Title:DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers
Method:PCR followed by restriction fragment length polymorphismenzymatic digestionandgel electrophoresisStudy Designcase-controlAddictive DrugnicotineBehavior:smoking quit time(30 days)
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1; TaqI repeat fragment length polymorphismOriginal Report:positive
Ethnic:EgyptianCase Sample Size96Control Sample Size171
Case Age:40(19-81)Case Male%100%Control Age40(19-81)Control Male%:100%
Case Minor:48Case Major144Case HWEYES
Control Minor126Control Major216Control HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical Informationsix-item Fagerstrom Test for Nicotine Dependence (FTND)
Allelic Contrast Test 140
KARG ID:ASSO0140PubMed ID9259374Year1999Author Name:Goldman D
Title:"Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians"
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:Southwestern American IndiansCase Sample Size276Control Sample Size161
Case Age:NACase Male%42.70%Control AgeNAControl Male%:42.70%
Case Minor:229.908Case Major322.092Case HWENA
Control Minor48.944Control Major273.056Control HWE:NA
Case AA:49.956Case AB129.996Case BB96.048
Control AA4.991Control AB38.962Control BB:117.047
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 141
KARG ID:ASSO0141PubMed ID9259374Year1999Author Name:Goldman D
Title:"Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance abuse
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:Southwestern American IndiansCase Sample Size170Control Sample Size267
Case Age:NACase Male%42.70%Control AgeNAControl Male%:42.70%
Case Minor:150.79Case Major196.01Case HWENA
Control Minor211.998Control Major322.002Control HWE:NA
Case AA:37.4Case AB75.99Case BB60.01
Control AA44.055Control AB123.888Control BB:99.057
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 142
KARG ID:ASSO0142PubMed ID7918698Year1994Author Name:Geijer T
Title:Dopamine D2-receptor gene polymorphisms in Scandinavian chronic alcoholics
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:DSM-III-R severe alcohol dependence
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:ScandinavianCase Sample Size56Control Sample Size81
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:22Case Major90Case HWENA
Control Minor34Control Major128Control HWE:NA
Case AA:2Case AB18Case BB36
Control AA5Control AB24Control BB:52
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 143
KARG ID:ASSO0143PubMed ID8102114Year1993Author Name:O'Hara BF
Title:"Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance use
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:CaucasiansCase Sample Size237Control Sample Size160
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:109Case Major365Case HWEOK
Control Minor51Control Major269Control HWE:OK
Case AA:13Case AB83Case BB141
Control AA6Control AB39Control BB:115
Curator:CYLClinical InformationARC
Allelic Contrast Test 144
KARG ID:ASSO0144PubMed ID8102114Year1993Author Name:O'Hara BF
Title:"Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance use
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:African-AmericanCase Sample Size102Control Sample Size100
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:72Case Major132Case HWEOK
Control Minor78Control Major122Control HWE:OK
Case AA:10Case AB52Case BB40
Control AA19Control AB40Control BB:41
Curator:CYLClinical InformationARC
Allelic Contrast Test 145
KARG ID:ASSO0145PubMed ID1355337Year1992Author Name:Smith SS
Title:Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance use
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:AA+EACase Sample Size125Control Sample Size36
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:52Case Major198Case HWEOK
Control Minor10Control Major62Control HWE:OK
Case AA:7Case AB38Case BB80
Control AA2Control AB6Control BB:28
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 146
KARG ID:ASSO0146PubMed ID11410714Year2001Author Name:Anghelescu I
Title:No association between the dopamine d2 receptor taqi a1 allele and earlier age of onset of alcohol dependence according to different specified criteria
Method:PCR followed by digestion(RFLP)Study Designcase-controlAddictive DrugalcoholBehavior:Alcohol Dependence
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:CaucasiansCase Sample Size243Control Sample Size98
Case Age:41.9 +- 7.6Case Male%77%Control AgeNAControl Male%:73.50%
Case Minor:101Case Major385Case HWENA
Control Minor38Control Major158Control HWE:NA
Case AA:13Case AB75Case BB155
Control AA3Control AB32Control BB:63
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 147
KARG ID:ASSO0147PubMed ID8488955Year1993Author Name:Goldman D
Title:"DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations"
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:Cheyenne IndiansCase Sample Size18Control Sample Size14
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:8Case Major28Case HWENA
Control Minor8Control Major20Control HWE:NA
Case AA:0Case AB8Case BB10
Control AA2Control AB4Control BB:8
Curator:CYLClinical InformationNIAAA
Allelic Contrast Test 148
KARG ID:ASSO0148PubMed ID8033754Year1994Author Name:Comings DE
Title:The dopamine D2 receptor gene: a genetic risk factor in substance abuse
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:Caucasian Case Sample Size94Control Sample Size763
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:56Case Major132Case HWENA
Control Minor442Control Major1084Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM 111-R
Allelic Contrast Test 149
KARG ID:ASSO0149PubMed ID8033754Year1994Author Name:Comings DE
Title:The dopamine D2 receptor gene: a genetic risk factor in substance abuse
Method:RFLPStudy Designcase-controlAddictive DrugmixedBehavior:mixed
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:Caucasian Case Sample Size104Control Sample Size763
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:88Case Major120Case HWENA
Control Minor443Control Major1083Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM 111-R
Allelic Contrast Test 150
KARG ID:ASSO0150PubMed ID8873216Year1996Author Name:Blum K
Title:Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugmixedBehavior:comorbid substance use
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:?CaucasiansCase Sample Size23Control Sample Size17
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:34Case Major12Case HWENA
Control Minor8Control Major26Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationNA
Allelic Contrast Test 151
KARG ID:ASSO0151PubMed ID14643564Year2003Author Name:Ponce G
Title:The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients
Method:PCR followed by digestionStudy DesigncaseAddictive DrugalcoholBehavior:alcohol-dependent
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:SpanishCase Sample Size103Control Sample Size0
Case Age:41?years (S.D. 9.3Case Male%100%Control AgeNAControl Male%:NA
Case Minor:46Case Major160Case HWEYES
Control MinorNAControl MajorNAControl HWE:NA
Case AA:6Case AB34Case BB63
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 152
KARG ID:ASSO0152PubMed ID15704216Year2005Author Name:Shahmoradgoli Najafabadi M
Title:Association between the DRD2 A1 allele and opium addiction in the Iranian population
Method:"three fragments: 310, 180, 130 bp"Study Designcase-controlAddictive DrugopioidsBehavior:opium-dependent
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:IranianCase Sample Size100Control Sample Size130
Case Age:33.9+-8.7Case Male%100%Control Age31.5+-5.6Control Male%:100%
Case Minor:59Case Major141Case HWENA
Control Minor24Control Major236Control HWE:NA
Case AA:10Case AB39Case BB51
Control AA2Control AB20Control BB:108
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 153
KARG ID:ASSO0153PubMed ID9129710Year1997Author Name:Chen WJ
Title:Dopamine D2 receptor gene and alcoholism among four aboriginal groups and Han in Taiwan
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:severe alcoholics
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:ChineseCase Sample Size203Control Sample Size213
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:166Case Major240Case HWENA
Control Minor163Control Major263Control HWE:NA
Case AA:28Case AB110Case BB65
Control AA30Control AB103Control BB:80
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 154
KARG ID:ASSO0154PubMed ID10881204Year2000Author Name:Gorwood P
Title:"Reappraisal of the association between the DRD2 gene, alcoholism and addiction"
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:FrenchCase Sample Size113Control Sample Size49
Case Age:43.6+-10.3Case Male%100%Control Age32.4+-12Control Male%:100%
Case Minor:88Case Major138Case HWEOK
Control Minor40Control Major58Control HWE:OK
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-III-R diagnostic of alcohol dependence
Allelic Contrast Test 155
KARG ID:ASSO0155PubMed ID11054765Year2000Author Name:Lawford BR
Title:The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugopioidsBehavior:heroin use
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:positive
Ethnic:Australian-born Caucasians of European descentCase Sample Size95Control Sample Size33
Case Age:28.4 +- 0.7 yearsCase Male%69.50%Control Age34.6 years +- 0.9 yearsControl Male%:38%
Case Minor:36Case Major154Case HWENA
Control Minor3Control Major63Control HWE:NA
Case AA:1Case AB34Case BB60
Control AA0Control AB3Control BB:30
Curator:CYLClinical InformationDSM-IV criteria for opioid dependence
Allelic Contrast Test 156
KARG ID:ASSO0156PubMed ID11236836Year2001Author Name:Pastorelli R
Title:Genetic determinants of alcohol addiction and metabolism: a survey in Italy
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent subjects
Gene Name:DRD2Marker NameTaq1AMarker InformationA2>A1Original Report:negative
Ethnic:white ItaliansCase Sample Size60Control Sample Size64
Case Age:46.4 years+-10.8Case Male%75%Control Age45+-9.51Control Male%:79.70%
Case Minor:19Case Major101Case HWENA
Control Minor17Control Major111Control HWE:NA
Case AA:2Case AB15Case BB43
Control AA2Control AB13Control BB:49
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 157
KARG ID:ASSO0157PubMed ID7918698Year1994Author Name:Geijer T
Title:Dopamine D2-receptor gene polymorphisms in Scandinavian chronic alcoholics
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:DSM-III-R severe alcohol dependence
Gene Name:DRD2Marker NameTaq1BMarker InformationB2>B1Original Report:negative
Ethnic:ScandinavianCase Sample Size55Control Sample Size81
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:21Case Major89Case HWENA
Control Minor31Control Major131Control HWE:NA
Case AA:2Case AB17Case BB36
Control AA4Control AB23Control BB:54
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 158
KARG ID:ASSO0158PubMed ID8102114Year1993Author Name:O'Hara BF
Title:"Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance use
Gene Name:DRD2Marker NameTaq1BMarker InformationB2>B1Original Report:positive
Ethnic:CaucasiansCase Sample Size237Control Sample Size160
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:84Case Major390Case HWEOK
Control Minor39Control Major281Control HWE:OK
Case AA:8Case AB68Case BB161
Control AA4Control AB31Control BB:125
Curator:CYLClinical InformationARC
Allelic Contrast Test 159
KARG ID:ASSO0159PubMed ID8102114Year1993Author Name:O'Hara BF
Title:"Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers"
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance use
Gene Name:DRD2Marker NameTaq1BMarker InformationB2>B1Original Report:negative
Ethnic:African-AmericanCase Sample Size102Control Sample Size100
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:27Case Major177Case HWEOK
Control Minor40Control Major160Control HWE:OK
Case AA:0Case AB27Case BB75
Control AA3Control AB34Control BB:63
Curator:CYLClinical InformationARC
Allelic Contrast Test 160
KARG ID:ASSO0160PubMed ID1355337Year1992Author Name:Smith SS
Title:Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers
Method:RFLPStudy Designcase-controlAddictive DrugmultipleBehavior:substance use
Gene Name:DRD2Marker NameTaq1BMarker InformationB2>B1Original Report:positive
Ethnic:AA+EACase Sample Size125Control Sample Size36
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:40Case Major210Case HWEOK
Control Minor7Control Major65Control HWE:OK
Case AA:3Case AB34Case BB88
Control AA2Control AB3Control BB:31
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 161
KARG ID:ASSO0161PubMed ID15084894Year2004Author Name:Huang SY
Title:Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence
Method:RFLPStudy Designcase-controlAddictive Druganxiety-depression alcohol dependenceBehavior:NA
Gene Name:DRD2Marker NameTaqIAMarker InformationNAOriginal Report:Positive
Ethnic:Han(taiwan)Case Sample Size226Control Sample Size304
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:Haplotype frequency (%)A1/B10.473Case ABA1/B2:0;A2/B10.031Case BBA2/B2:0.496
Control AAA1/B1:0.338Control ABA1/B2:0.014;A2/B1:0.033Control BB:A2/B2:0.615
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 162
KARG ID:ASSO0162PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker NameTaqIA Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size486Control Sample Size313
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:390Case Major582Case HWEOK
Control Minor237Control Major389Control HWE:OK
Case AA:78Case AB234Case BB174
Control AA44Control AB149Control BB:120
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 163
KARG ID:ASSO0163PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker NameTaqIAMarker InformationG>AOriginal Report:negative
Ethnic:GermanCase Sample Size455Control Sample Size191
Case Age:30.2 +- 6.8Case Male%NAControl Age31.8 +- 7.0Control Male%:NA
Case Minor:179Case Major731Case HWEOK
Control Minor77Control Major305Control HWE:OK
Case AA:17Case AB145Case BB293
Control AA7Control AB63Control BB:121
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 164
KARG ID:ASSO0164PubMed ID11236836Year2001Author Name:Pastorelli R
Title:Genetic determinants of alcohol addiction and metabolism: a survey in Italy
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol-dependent subjects
Gene Name:DRD2Marker NameTaqIBMarker InformationB2>B1Original Report:negative
Ethnic:white ItaliansCase Sample Size60Control Sample Size64
Case Age:46.4 years+-10.8Case Male%75%Control Age45+-9.51Control Male%:79.70%
Case Minor:13Case Major107Case HWENA
Control Minor11Control Major117Control HWE:NA
Case AA:0Case AB13Case BB47
Control AA1Control AB9Control BB:54
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 165
KARG ID:ASSO0165PubMed ID15955630Year2005Author Name:Costa-Mallen P
Title:Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men
Method:PCR-RFLPStudy Designcase-controlAddictive DrugnicotineBehavior:Ever-smokers/Never-smokers
Gene Name:DRD2Marker NameTaqIBMarker InformationA>GOriginal Report:negative
Ethnic:Seattle area residentsCase Sample Size232Control Sample Size158
Case Age:44-84Case Male%60.80%Control Age44-84Control Male%:60.80%
Case Minor:126Case Major178Case HWENA
Control Minor100Control Major139Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical Information"in-person structured interviews:Subjects were considered as ""ever-smokers"" if they had smoked at least 100 cigarettes in their lifetime. "
Allelic Contrast Test 166
KARG ID:ASSO0166PubMed ID15184239Year2006Author Name:Xu K
Title:Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
Method:5'-exonuclease assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin-dependent
Gene Name:DRD2Marker NameTaqIDMarker InformationG>AOriginal Report:positive
Ethnic:ChineseCase Sample Size472Control Sample Size301
Case Age:27.3 +- 5.80Case Male%NAControl Age28.0 +- 10.0Control Male%:NA
Case Minor:42Case Major902Case HWEOK
Control Minor47Control Major555Control HWE:OK
Case AA:2Case AB38Case BB432
Control AA1Control AB45Control BB:255
Curator:CYLClinical Information"Patients were interviewed with the Structured Clinical Interview for DSM-III-R Axis I disorders, and diagnosed as opiate dependent by 2 psychiatrists using DSM-IV criteria"
Allelic Contrast Test 167
KARG ID:ASSO0167PubMed ID11920858Year2002Author Name:Li T
Title:"Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects"
Method:RFLPStudy Designcase-controlAddictive Drugheroine abuserBehavior:NA
Gene Name:DRD2Marker NameNAMarker Informationser311CysOriginal Report:nagative
Ethnic:NACase Sample Size121Control Sample Size194
Case Age:27.49+/-5.85Case Male%NAControl Age28.60+/-9.27Control Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationNA
Allelic Contrast Test 168
KARG ID:ASSO0168PubMed ID15066703Year2004Author Name:Konishi T
Title:"Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans"
Method:RFLPStudy Designcase-controlAddictive DrugAlcoholismBehavior:NA
Gene Name:DRD2 -141C InsMarker NameNAMarker InformationNAOriginal Report:positive
Ethnic:Mexican-AmericansCase Sample Size130Control Sample Size251
Case Age:38.2 +/- 11.8Case Male%100.00%Control Age32.5+/- 9.2Control Male%:41.80%
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:Del/Del18 (13.9)Case ABIns/Del:18 (13.9)Case BB(Ins/Ins106 (81.5)13.9)
Control AA7 (2.8)Control AB70 (27.9)Control BB:174 (69.3)
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 169
KARG ID:ASSO0169PubMed ID15564898Year2004Author Name:Chen CK
Title:Association analysis of dopamine D2-like receptor genes and methamphetamine abuse
Method:RFLPStudy Designcase-controlAddictive Drugmethamphetamine abuserBehavior:NA
Gene Name:DRD2 Marker NameTaqIAMarker InformationNAOriginal Report:Nagative
Ethnic:NACase Sample SizeNAControl Sample SizeNA
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:A1341 (41.0)Case MajorA2491 (59.0)Case HWENA
Control MinorA1368 (42.3)Control MajorA2502 (57.7)Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 170
KARG ID:ASSO0170PubMed ID17069991Year2007Author Name:Sakai JT
Title:Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems.
Method:TaqManStudy Designcase-controlAddictive DrugalcoholBehavior:lifetime alcohol abuse or dependence
Gene Name:DRD2Marker NameTaqIAMarker InformationNAOriginal Report:Nagative
Ethnic:Caes/control:Caucasian114 (47.7%)/84 (55.6%);Hispanic87 (36.4%)/50 (33.1%);Other38 (15.9%)/17 (11.3%).Case Sample Size239Control Sample Size151
Case Age:15.7Case Male%206(86.2%)Control Age13-19(mean15.6)Control Male%:matched
Case Minor:"A1A124 (10.0%),A1A283 (34.7%)"Case MajorA2A2132 (55.2%)Case HWENA
Control Minor"A1A1:10 (6.6%),A1A2:60 (39.7%)"Control MajorA2A2:81 (53.6%)Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-IV
Allelic Contrast Test 171
KARG ID:ASSO0171PubMed ID8825889Year1995Author Name:Gorwood P
Title:Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholics
Gene Name:DRD3Marker NameBal IMarker Information1>2Original Report:negative
Ethnic:mixedCase Sample Size26Control Sample Size27
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:23Case Major29Case HWEYES
Control Minor22Control Major32Control HWE:YES
Case AA:4Case AB15Case BB7
Control AA5Control AB12Control BB:10
Curator:CYLClinical InformationDSM-111-R
Allelic Contrast Test 172
KARG ID:ASSO0172PubMed ID8825889Year1995Author Name:Gorwood P
Title:Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholics
Gene Name:DRD3Marker NameBal IMarker Information1>2Original Report:negative
Ethnic:CaucasianCase Sample Size35Control Sample Size35
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:33Case Major37Case HWEYES
Control Minor31Control Major39Control HWE:YES
Case AA:9Case AB15Case BB11
Control AA6Control AB19Control BB:10
Curator:CYLClinical InformationDSM-111-R
Allelic Contrast Test 173
KARG ID:ASSO0173PubMed ID8825889Year1995Author Name:Gorwood P
Title:Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholics
Gene Name:DRD3Marker NameBal IMarker Information1>2Original Report:negative
Ethnic:CaucasianCase Sample Size72Control Sample Size66
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:49Case Major95Case HWEYES
Control Minor38Control Major94Control HWE:YES
Case AA:9Case AB31Case BB32
Control AA5Control AB28Control BB:33
Curator:CYLClinical InformationSCID-1
Allelic Contrast Test 174
KARG ID:ASSO0174PubMed ID9702742Year1998Author Name:Duaux E
Title:Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugopioidsBehavior:"opiate dependence, sensation-seeking score>24"
Gene Name:DRD3Marker NameBal IMarker Information1>2Original Report:positive
Ethnic:white males of French ancestryCase Sample Size38Control Sample Size70
Case Age:32.3 +- 6.1Case Male%100%Control Age42.2 +- 7Control Male%:100%
Case Minor:25Case Major51Case HWE"NO, P = 0.048"
Control Minor41Control Major99Control HWE:YES
Case AA:8Case AB9Case BB21
Control AA5Control AB31Control BB:34
Curator:CYLClinical InformationDSM-III- R criteria
Allelic Contrast Test 175
KARG ID:ASSO0175PubMed ID12811641Year2003Author Name:Wiesbeck GA
Title:Dopamine D2 (DAD2) and dopamine D3 (DAD3) receptor gene polymorphisms and treatment outcome in alcohol dependence
Method:RFLP assayStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol abstainers/relapsers
Gene Name:DRD3Marker NameBal IMarker InformationA1>A2Original Report:negative
Ethnic:GermanCase Sample Size55Control Sample Size49
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:23Case Major87Case HWENA
Control Minor20Control Major78Control HWE:NA
Case AA:3Case AB17Case BB35
Control AA4Control AB12Control BB:33
Curator:CYLClinical Information"ICD-10 criteria using a German version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA; Buchholz et al., 1994)."
Allelic Contrast Test 176
KARG ID:ASSO0176PubMed ID10483044Year1999Author Name:Kotler M
Title:No association between the serotonin transporter promoter region (5-HTTLPR) and the dopamine D3 receptor (BalI D3DR) polymorphisms and heroin addiction
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugopioidsBehavior:heroin addiction
Gene Name:DRD3Marker NameBalIMarker InformationGly>SerOriginal Report:negative
Ethnic:Sephardic Jews/Israeli ArabsCase Sample Size193Control Sample Size134
Case Age:32.4 +- 0.54Case Male%100%Control Age45.8 +- 2.28Control Male%:100%
Case Minor:143Case Major243Case HWENA
Control Minor97Control Major171Control HWE:NA
Case AA:24Case AB95Case BB74
Control AA22Control AB53Control BB:59
Curator:CYLClinical InformationDSM-IV criteria for opioid use disorders
Allelic Contrast Test 177
KARG ID:ASSO0177PubMed ID17671965Year2007Author Name:Ballon N
Title:"Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?"
Method:"amplifications used a PTC-100 thermocycler (MJ Research Inc.) and thermostable Taq Polymerase (AmpliTaq, Perkin Elmer Cetus). "Study Designcase-controlAddictive DrugcocaineBehavior:"smoked-cocaine dependents, 95 cannabis abusers and 77 alcohol abusers"
Gene Name:DRD3Marker NameNAMarker InformationBal IOriginal Report:negative
Ethnic:African-CaribbeanCase Sample Size97Control Sample Size88
Case Age:35.8+-6.6Case Male%100%Control Age39.5+-10.2Control Male%:100%
Case Minor:67Case Major127Case HWEYES
Control Minor64Control Major112Control HWE:YES
Case AA:10Case AB47Case BB40
Control AA10Control AB44Control BB:34
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 178
KARG ID:ASSO0178PubMed ID11920858Year2002Author Name:Li T
Title:"Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects"
Method:RFLPStudy Designcase-controlAddictive DrugNABehavior:NA
Gene Name:DRD3Marker NameNAMarker InformationSer9GlyOriginal Report:nagative
Ethnic:NACase Sample SizeNAControl Sample SizeNA
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationNA
Allelic Contrast Test 179
KARG ID:ASSO0179PubMed ID15564898Year2004Author Name:Chen CK
Title:Association analysis of dopamine D2-like receptor genes and methamphetamine abuse
Method:RFLPStudy Designcase-controlAddictive Drugmethamphetamine abuserBehavior:NA
Gene Name:DRD3 Marker NameNAMarker InformationSer9GlyOriginal Report:Nagative
Ethnic:NACase Sample SizeNAControl Sample SizeNA
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:Gly:240 (29.1)Case MajorSer-9:584 (70.9)Case HWENA
Control Minor259 (30.0)Control Major605 (70.0)Control HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 180
KARG ID:ASSO0180PubMed ID15274053Year2004Author Name:Li T
Title:Association analysis of the DRD4 and COMT genes in methamphetamine abuse
Method:PCR amplificationStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine-induced psychosis
Gene Name:DRD4Marker Name120 bp Promoter VNTR PolymorphismMarker Information240bp>120bpOriginal Report:negative
Ethnic:ChineseCase Sample Size142Control Sample Size415
Case Age:27.2?+-?7.0Case Male%63.20%Control Age34.4?+-?10.0Control Male%:57%
Case Minor:83Case Major201Case HWENA
Control Minor229Control Major601Control HWE:NA
Case AA:11Case AB61Case BB70
Control AA34Control AB161Control BB:220
Curator:CYLClinical Information"DSM-IV criteria following an interview with the Chinese version of Diagnostic Interview for Genetic Studies [DIGS-C; Chen et al., [2004]]"
Allelic Contrast Test 181
KARG ID:ASSO0181PubMed ID15274053Year2004Author Name:Li T
Title:Association analysis of the DRD4 and COMT genes in methamphetamine abuse
Method:PCR amplificationStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users with no psychosis
Gene Name:DRD4Marker Name120 bp Promoter VNTR PolymorphismMarker Information240bp>120bpOriginal Report:negative
Ethnic:ChineseCase Sample Size262Control Sample Size415
Case Age:27.2?+-?7.0Case Male%63.20%Control Age34.4?+-?10.0Control Male%:57%
Case Minor:168Case Major356Case HWENA
Control Minor229Control Major601Control HWE:NA
Case AA:27Case AB114Case BB121
Control AA34Control AB161Control BB:220
Curator:CYLClinical Information"DSM-IV criteria following an interview with the Chinese version of Diagnostic Interview for Genetic Studies [DIGS-C; Chen et al., [2004]]"
Allelic Contrast Test 182
KARG ID:ASSO0182PubMed ID16930369Year2006Author Name:Cevoli S
Title:A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse
Method:NAStudy Designcase-controlAddictive DrugmixedBehavior:chronic daily headache associated with DA
Gene Name:DRD4Marker Name2/3/4/7/otherMarker InformationNAOriginal Report:positive
Ethnic:CaucasianCase Sample Size97Control Sample Size203
Case Age:23-81?Case Male%NAControl AgeNAControl Male%:NA
Case Minor:2:34;3:12;4:311;7:40;other:9Case MajorNACase HWEYES
Control Minor2:15;3:7;4:138;7:31;other:3Control MajorNAControl HWE:YES
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationInternational Headache Society (IHS)
Allelic Contrast Test 183
KARG ID:ASSO0183PubMed ID7573171Year1995Author Name:Adamson MD
Title:DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls
Method:RFLPStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholics
Gene Name:DRD4Marker Name48-bp repeatMarker Information2/3/4/5/6/7/8Original Report:negative
Ethnic:FinishCase Sample Size113Control Sample Size113
Case Age:NACase Male%100%Control AgeNAControl Male%:100%
Case Minor:2:13;3:18;4:144;5:9;6:2;7:36;8:0Case MajorNACase HWENA
Control Minor2:13;3:20;4:144;5:7;6:0;7:38;8:2Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM 111-R
Allelic Contrast Test 184
KARG ID:ASSO0184PubMed ID11054768Year2000Author Name:Li T
Title:Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugopioidsBehavior:Heroin abuse
Gene Name:DRD4Marker Name48-bp VNTR PolymorphismMarker Information1/2/3/4/5/6/7Original Report:negative
Ethnic:ChineseCase Sample Size405Control Sample Size304
Case Age:29.49 +- 5.85Case Male%70.60%Control Age35.64 +- 19.16Control Male%:70.60%
Case Minor:1:1;2:178;3:11;4:577;5:26;6:14;7:3Case MajorNACase HWENA
Control Minor1:0;2:114;3:7;4:466;5:8;6:13;7:0Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 185
KARG ID:ASSO0185PubMed ID10673776Year2000Author Name:Franke P
Title:DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach
Method:as described by Lichter et al.Study Designcase-controlAddictive DrugopioidsBehavior:opioid dependence
Gene Name:DRD4Marker Nameexon III VNTRMarker Information2/3/4/5/6/7Original Report:negative
Ethnic:German originCase Sample Size285Control Sample Size197
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:2:51;2:30;4:364;5:4;6:2;7:109;8:9;9:1Case MajorNACase HWENA
Control Minor2:28;2:13;4:276;5:13;6:2;7:60;8:2;9:0Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-III-R criteria for opioid dependence
Allelic Contrast Test 186
KARG ID:ASSO0186PubMed ID9322237Year1997Author Name:Li T
Title:Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects
Method:RFLPStudy Designcase-controlAddictive DrugopioidsBehavior:heroin abuse
Gene Name:DRD4Marker Nameexon III VNTRMarker Information2/3/4/5/6/7Original Report:positive
Ethnic:ChineseCase Sample Size121Control Sample Size154
Case Age:26.97 +-4.95Case Male%72.70%Control Age28.6+-9.27Control Male%:59.70%
Case Minor:2:47;3:3;4:173;5:12;6:5;7:2Case MajorNACase HWENA
Control Minor2:55;3:5;4:237;5:5;6:6;7:0Control MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 187
KARG ID:ASSO0187PubMed ID17671965Year2007Author Name:Ballon N
Title:"Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?"
Method:"amplifications used a PTC-100 thermocycler (MJ Research Inc.) and thermostable Taq Polymerase (AmpliTaq, Perkin Elmer Cetus). "Study Designcase-controlAddictive DrugcocaineBehavior:"smoked-cocaine dependents, 95 cannabis abusers and 77 alcohol abusers"
Gene Name:DRD4Marker NameNAMarker Informationexon III polimorphismsOriginal Report:negative
Ethnic:African-CaribbeanCase Sample Size97Control Sample Size88
Case Age:35.8+-6.6Case Male%100%Control Age39.5+-10.2Control Male%:100%
Case Minor:2:11;3:4;4:129;5:10;6:2;7:29;8:8;10:1Case MajorNACase HWENA
Control Minor2:11;3:4;4:125;5:6;6:2;7:25;8:3;10:0Control MajorNAControl HWE:NA
Case AA:6Case AB48Case BB43
Control AA5Control AB37Control BB:46
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 188
KARG ID:ASSO0188PubMed ID11054768Year2000Author Name:Li T
Title:Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects
Method:polymerase chain reaction-restriction fragment length polymorphism methodsStudy Designcase-controlAddictive DrugopioidsBehavior:Heroin abuse
Gene Name:DRD4Marker NamePromoter -521C/TMarker InformationT>COriginal Report:negative
Ethnic:ChineseCase Sample Size344Control Sample Size211
Case Age:29.49 +- 5.85Case Male%70.60%Control Age35.64 +- 19.16Control Male%:70.60%
Case Minor:306Case Major382Case HWENA
Control Minor170Control Major252Control HWE:NA
Case AA:115Case AB76Case BB153
Control AA58Control AB54Control BB:99
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 189
KARG ID:ASSO0189PubMed ID15564898Year2004Author Name:Chen CK
Title:Association analysis of dopamine D2-like receptor genes and methamphetamine abuse
Method:RFLPStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine abuser
Gene Name:DRD4Marker Nameexon III VNTRMarker Information2/3/4/5/6/7Original Report:nagative
Ethnic:NACase Sample SizeNAControl Sample SizeNA
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:To muchCase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 190
KARG ID:ASSO0190PubMed ID9583233Year1998Author Name:Vanyukov MM
Title:An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugmixedBehavior:substance dependence (SA) or without any psychiatric disorder
Gene Name:DRD5Marker NameD5(CT/GT/GA)nMarker Informationnon9>9Original Report:positive
Ethnic:European-AmericanCase Sample Size28Control Sample Size57
Case Age:41.6 +- 0.76Case Male%100%Control Age35-64Control Male%:100%
Case Minor:28Case Major28Case HWENA
Control Minor36Control Major78Control HWE:NA
Case AA:7Case AB14Case BB7
Control AA6Control AB24Control BB:27
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 191
KARG ID:ASSO0191PubMed ID9583233Year1998Author Name:Vanyukov MM
Title:An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study
Method:PCR followed by digestionStudy Designcase-controlAddictive DrugmixedBehavior:substance dependence (SA) or without any psychiatric disorder
Gene Name:DRD5Marker NameD5(CT/GT/GA)nMarker Informationnon9>9Original Report:positive
Ethnic:European-AmericanCase Sample Size14Control Sample Size57
Case Age:40.6 +- 0.53Case Male%0%Control Age35-52Control Male%:0%
Case Minor:22Case Major6Case HWENA
Control Minor46Control Major68Control HWE:NA
Case AA:8Case AB6Case BB0
Control AA10Control AB26Control BB:21
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 192
KARG ID:ASSO0192PubMed ID17621164Year2007Author Name:Iwasaki S
Title:Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Method:TaqMan 5' nuclease assays with an ABI PRISM 7900 HT Sequence Detection SystemStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:FAAHMarker Namers11576941Marker InformationG>TOriginal Report:negative
Ethnic:JapanCase Sample Size722Control Sample Size778
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:640Case Major804Case HWEN.A
Control Minor694Control Major862Control HWE:N.A
Case AA:144Case AB352Case BB226
Control AA154Control AB386Control BB:238
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 193
KARG ID:ASSO0193PubMed ID17621164Year2007Author Name:Iwasaki S
Title:Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Method:TaqMan 5' nuclease assays with an ABI PRISM 7900 HT Sequence Detection SystemStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:FAAHMarker Namers324420Marker InformationC>AOriginal Report:negative
Ethnic:JapanCase Sample Size719Control Sample Size794
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:255Case Major1183Case HWEN.A
Control Minor272Control Major1316Control HWE:N.A
Case AA:24Case AB207Case BB488
Control AA19Control AB234Control BB:541
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 194
KARG ID:ASSO0194PubMed ID17290447Year2007Author Name:Tyndale RF
Title:The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians
Method:allele-specific oligonucleotide hybridization (ASOH)Study Designcase-controlAddictive DrugcannabisBehavior:cannabis dependent
Gene Name:FAAHMarker Namers324420Marker InformationC>AOriginal Report:positive
Ethnic:CaucasianCase Sample Size127Control Sample Size362
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:3Case ABNACase BBCombine: 124
Control AA24Control ABNAControl BB:Combine:338
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 195
KARG ID:ASSO0195PubMed ID17621164Year2007Author Name:Iwasaki S
Title:Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Method:TaqMan 5' nuclease assays with an ABI PRISM 7900 HT Sequence Detection SystemStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:FAAHMarker Namers3737744Marker InformationA>GOriginal Report:negative
Ethnic:JapanCase Sample Size712Control Sample Size777
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:649Case Major775Case HWEN.A
Control Minor715Control Major839Control HWE:N.A
Case AA:156Case AB337Case BB219
Control AA169Control AB377Control BB:231
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 196
KARG ID:ASSO0196PubMed ID17621164Year2007Author Name:Iwasaki S
Title:Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Method:TaqMan 5' nuclease assays with an ABI PRISM 7900 HT Sequence Detection SystemStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:FAAHMarker Namers4660344Marker InformationA>GOriginal Report:negative
Ethnic:JapanCase Sample Size721Control Sample Size752
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:678Case Major764Case HWEN.A
Control Minor730Control Major774Control HWE:N.A
Case AA:171Case AB336Case BB214
Control AA186Control AB358Control BB:208
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 197
KARG ID:ASSO0197PubMed ID17621164Year2007Author Name:Iwasaki S
Title:Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
Method:TaqMan 5' nuclease assays with an ABI PRISM 7900 HT Sequence Detection SystemStudy Designcase-controlAddictive DrugalcoholBehavior:alcoholism
Gene Name:FAAHMarker Namers9865Marker InformationA>GOriginal Report:negative
Ethnic:JapanCase Sample Size683Control Sample Size765
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:451Case Major915Case HWEN.A
Control Minor481Control Major1049Control HWE:N.A
Case AA:82Case AB287Case BB314
Control AA69Control AB343Control BB:353
Curator:CYLClinical InformationDSM-III-R
Allelic Contrast Test 198
KARG ID:ASSO0198PubMed ID16972078Year2006Author Name:Flanagan JM
Title:The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction
Method:Sequencing by capillary electrophoresis using an ABI PRISM 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugmixedBehavior:risk for drug addiction
Gene Name:FAAH Marker Namers324420Marker InformationP>TOriginal Report:positive
Ethnic:CaucasianCase Sample Size27Control Sample Size579
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:8Case Major46Case HWEYES
Control Minor203Control Major955Control HWE:YES
Case AA:1Case AB6Case BB20
Control AA12Control AB179Control BB:388
Curator:CYLClinical InformationNIDA/IRP structured interviews and examinations
Allelic Contrast Test 199
KARG ID:ASSO0199PubMed ID16972078Year2006Author Name:Flanagan JM
Title:The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction
Method:Sequencing by capillary electrophoresis using an ABI PRISM 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugmixedBehavior:risk for drug addiction
Gene Name:FAAH Marker Namers324420Marker InformationP>TOriginal Report:positive
Ethnic:AsianCase Sample Size2Control Sample Size88
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:2Case Major2Case HWEYES
Control Minor40Control Major136Control HWE:YES
Case AA:1Case AB0Case BB1
Control AA5Control AB30Control BB:53
Curator:CYLClinical InformationNIDA/IRP structured interviews and examinations
Allelic Contrast Test 200
KARG ID:ASSO0200PubMed ID16972078Year2006Author Name:Flanagan JM
Title:The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction
Method:Sequencing by capillary electrophoresis using an ABI PRISM 3100 Genetic AnalyzerStudy Designcase-controlAddictive DrugmixedBehavior:risk for drug addiction
Gene Name:FAAH Marker Namers324420Marker InformationP>TOriginal Report:positive
Ethnic:African-AmericanCase Sample Size220Control Sample Size118
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:156Case Major284Case HWEYES
Control Minor63Control Major173Control HWE:YES
Case AA:25Case AB106Case BB89
Control AA8Control AB47Control BB:63
Curator:CYLClinical InformationNIDA/IRP structured interviews and examinations
Allelic Contrast Test 201
KARG ID:ASSO0201PubMed ID11920858Year2002Author Name:Li T
Title:"Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects"
Method:RFLPStudy Designcase-controlAddictive Drugheroine abuserBehavior:NA
Gene Name:GABAyAMarker NameNAMarker Information3145G/AOriginal Report:nagative
Ethnic:NACase Sample Size121Control Sample Size194
Case Age:27.49+/-5.85Case Male%NAControl Age28.60+/-9.27Control Male%:NA
Case Minor:NACase MajorNACase HWENA
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationNA
Allelic Contrast Test 202
KARG ID:ASSO0202PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRA1Marker Namers2279020Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size141Control Sample Size244
Case Age:28.73+-7.14Case Male%100%Control Age35.13+-9.93Control Male%:100%
Case Minor:119Case Major163Case HWEYES
Control Minor208Control Major280Control HWE:YES
Case AA:22Case AB75Case BB44
Control AA45Control AB118Control BB:81
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 203
KARG ID:ASSO0203PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRA1Marker Namers2279020Marker InformationG>AOriginal Report:positive
Ethnic:ChineseCase Sample Size105Control Sample Size188
Case Age:25.29+-6.23Case Male%0%Control Age32.93+-10.14Control Male%:0%
Case Minor:90Case Major120Case HWEYES
Control Minor193Control Major183Control HWE:YES
Case AA:24Case AB42Case BB39
Control AA55Control AB83Control BB:50
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 204
KARG ID:ASSO0204PubMed ID17440936Year2007Author Name:Loh EW
Title:Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Method:AvaII RFLP assay Study Designcase-controlAddictive DrugopioidsBehavior:heroin dependence
Gene Name:GABRA1Marker Namers2279020Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size175Control Sample Size170
Case Age:36.48?+-?11.30Case Male%100%Control Age36.48?+-?11.30Control Male%:100%
Case Minor:155Case Major195Case HWE1
Control Minor149Control Major191Control HWE:0.755
Case AA:34Case AB87Case BB54
Control AA34Control AB81Control BB:55
Curator:CYLClinical InformationDSM-IV diagnostic criteria for opiate dependence
Allelic Contrast Test 205
KARG ID:ASSO0205PubMed ID17440936Year2007Author Name:Loh EW
Title:Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Method:AlwNI RFLP assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin dependence
Gene Name:GABRA6Marker Namers3219151Marker InformationC>TOriginal Report:negative
Ethnic:ChineseCase Sample Size176Control Sample Size170
Case Age:36.48?+-?11.30Case Male%100%Control Age36.48?+-?11.30Control Male%:100%
Case Minor:88Case Major264Case HWE0.423
Control Minor103Control Major237Control HWE:0.106
Case AA:13Case AB62Case BB101
Control AA20Control AB63Control BB:87
Curator:CYLClinical InformationDSM-IV diagnostic criteria for opiate dependence
Allelic Contrast Test 206
KARG ID:ASSO0206PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRA6Marker Namers4480562Marker InformationC>TOriginal Report:negative
Ethnic:ChineseCase Sample Size142Control Sample Size248
Case Age:28.73+-7.14Case Male%100%Control Age35.13+-9.93Control Male%:100%
Case Minor:85Case Major199Case HWEYES
Control Minor154Control Major342Control HWE:YES
Case AA:19Case AB47Case BB76
Control AA29Control AB96Control BB:123
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 207
KARG ID:ASSO0207PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRA6Marker Namers4480562Marker InformationC>TOriginal Report:negative
Ethnic:ChineseCase Sample Size105Control Sample Size187
Case Age:25.29+-6.23Case Male%0%Control Age32.93+-10.14Control Male%:0%
Case Minor:62Case Major148Case HWEYES
Control Minor129Control Major245Control HWE:YES
Case AA:11Case AB40Case BB54
Control AA24Control AB81Control BB:82
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 208
KARG ID:ASSO0208PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRB2Marker Namers2229944Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size142Control Sample Size247
Case Age:28.73+-7.14Case Male%100%Control Age35.13+-9.93Control Male%:100%
Case Minor:8Case Major276Case HWEYES
Control Minor18Control Major476Control HWE:YES
Case AA:0Case AB8Case BB134
Control AA1Control AB16Control BB:230
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 209
KARG ID:ASSO0209PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRB2Marker Namers2229944Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size106Control Sample Size190
Case Age:25.29+-6.23Case Male%0%Control Age32.93+-10.14Control Male%:0%
Case Minor:11Case Major201Case HWEYES
Control Minor13Control Major367Control HWE:YES
Case AA:1Case AB9Case BB96
Control AA0Control AB13Control BB:177
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 210
KARG ID:ASSO0210PubMed ID17440936Year2007Author Name:Loh EW
Title:Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Method:BanI restriction fragment length polymorphism (RFLP) assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin dependence
Gene Name:GABRB2Marker Namers2229944Marker InformationC>TOriginal Report:negative
Ethnic:ChineseCase Sample Size178Control Sample Size170
Case Age:36.48?+-?11.30Case Male%100%Control Age36.48?+-?11.30Control Male%:100%
Case Minor:14Case Major142Case HWE1
Control Minor20Control Major320Control HWE:1
Case AA:0Case AB14Case BB64
Control AA0Control AB20Control BB:150
Curator:CYLClinical InformationDSM-IV diagnostic criteria for opiate dependence
Allelic Contrast Test 211
KARG ID:ASSO0211PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRG2Marker Namers211013Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size142Control Sample Size248
Case Age:28.73+-7.14Case Male%100%Control Age35.13+-9.93Control Male%:100%
Case Minor:88Case Major196Case HWEYES
Control Minor151Control Major345Control HWE:YES
Case AA:14Case AB60Case BB68
Control AA25Control AB101Control BB:122
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 212
KARG ID:ASSO0212PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRG2Marker Namers211013Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size106Control Sample Size190
Case Age:25.29+-6.23Case Male%0%Control Age32.93+-10.14Control Male%:0%
Case Minor:70Case Major142Case HWEYES
Control Minor116Control Major264Control HWE:YES
Case AA:6Case AB58Case BB42
Control AA21Control AB74Control BB:95
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 213
KARG ID:ASSO0213PubMed ID17440936Year2007Author Name:Loh EW
Title:Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Method:NciI RFLP assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin dependence
Gene Name:GABRG2Marker Namers211013Marker InformationG>AOriginal Report:negative
Ethnic:ChineseCase Sample Size176Control Sample Size170
Case Age:36.48?+-?11.30Case Male%100%Control Age36.48?+-?11.30Control Male%:100%
Case Minor:107Case Major245Case HWE0.724
Control Minor91Control Major249Control HWE:0.7
Case AA:15Case AB77Case BB84
Control AA13Control AB65Control BB:92
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 214
KARG ID:ASSO0214PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRG2Marker Namers211014Marker InformationA>COriginal Report:negative
Ethnic:ChineseCase Sample Size140Control Sample Size246
Case Age:28.73+-7.14Case Male%100%Control Age35.13+-9.93Control Male%:100%
Case Minor:149Case Major131Case HWEYES
Control Minor241Control Major251Control HWE:YES
Case AA:44Case AB61Case BB35
Control AA62Control AB117Control BB:67
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 215
KARG ID:ASSO0215PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRG2Marker Namers211014Marker InformationA>COriginal Report:negative
Ethnic:ChineseCase Sample Size106Control Sample Size190
Case Age:25.29+-6.23Case Male%0%Control Age32.93+-10.14Control Male%:0%
Case Minor:116Case Major96Case HWEYES
Control Minor197Control Major183Control HWE:YES
Case AA:29Case AB58Case BB19
Control AA57Control AB83Control BB:50
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 216
KARG ID:ASSO0216PubMed ID17440936Year2007Author Name:Loh EW
Title:Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Method:BamHI RFLP assayStudy Designcase-controlAddictive DrugopioidsBehavior:heroin dependence
Gene Name:GABRG2Marker Namers211014Marker InformationC>AOriginal Report:positive
Ethnic:ChineseCase Sample Size178Control Sample Size170
Case Age:36.48?+-?11.30Case Male%100%Control Age36.48?+-?11.30Control Male%:100%
Case Minor:157Case Major199Case HWE1
Control Minor180Control Major160Control HWE:0.879
Case AA:34Case AB89Case BB55
Control AA47Control AB86Control BB:37
Curator:CYLClinical InformationDSM-IV diagnostic criteria for opiate dependence
Allelic Contrast Test 217
KARG ID:ASSO0217PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRG2Marker Namers4480617Marker InformationC>TOriginal Report:negative
Ethnic:ChineseCase Sample Size142Control Sample Size247
Case Age:28.73+-7.14Case Male%100%Control Age35.13+-9.93Control Male%:100%
Case Minor:10Case Major274Case HWEYES
Control Minor17Control Major477Control HWE:YES
Case AA:0Case AB10Case BB132
Control AA1Control AB15Control BB:231
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 218
KARG ID:ASSO0218PubMed ID14569258Year2003Author Name:Lin SK
Title:Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder
Method:RFLP assayStudy Designcase-controlAddictive DrugmethamphetamineBehavior:methamphetamine users
Gene Name:GABRG2Marker Namers4480617Marker InformationC>TOriginal Report:positive
Ethnic:ChineseCase Sample Size106Control Sample Size190
Case Age:25.29+-6.23Case Male%0%Control Age32.93+-10.14Control Male%:0%
Case Minor:17Case Major195Case HWEYES
Control Minor11Control Major369Control HWE:YES
Case AA:1Case AB15Case BB90
Control AA0Control AB11Control BB:179
Curator:CYLClinical InformationDSMIV clinical diagnosis of methamphetamine abuse
Allelic Contrast Test 219
KARG ID:ASSO0219PubMed ID17440936Year2007Author Name:Loh EW
Title:Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Method:MseI RFLPStudy Designcase-controlAddictive DrugopioidsBehavior:heroin dependence
Gene Name:GABRG2Marker Namers4480617Marker InformationT>COriginal Report:negative
Ethnic:ChineseCase Sample Size175Control Sample Size170
Case Age:36.48?+-?11.30Case Male%100%Control Age36.48?+-?11.30Control Male%:100%
Case Minor:5Case Major345Case HWE1
Control Minor9Control Major331Control HWE:0.103
Case AA:0Case AB5Case BB170
Control AA1Control AB7Control BB:162
Curator:CYLClinical InformationDSM-IV diagnostic criteria for opiate dependence
Allelic Contrast Test 220
KARG ID:ASSO0220PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers10439259Marker InformationA>GOriginal Report:positive
Ethnic:AsianCase Sample Size138Control Sample Size140
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:55Case Major221Case HWE"NO, P=0.004"
Control Minor33Control Major247Control HWE:"YES, P=0.114"
Case AA:0Case AB55Case BB83
Control AA0Control AB33Control BB:107
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 221
KARG ID:ASSO0221PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers2270335Marker InformationG>AOriginal Report:positive
Ethnic:AsianCase Sample Size138Control Sample Size145
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:64Case Major212Case HWE"YES, P=0.15"
Control Minor96Control Major194Control HWE:"YES, P=0.852"
Case AA:4Case AB56Case BB78
Control AA15Control AB66Control BB:64
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 222
KARG ID:ASSO0222PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers3749034Marker InformationC>TOriginal Report:positive
Ethnic:AsianCase Sample Size140Control Sample Size146
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:70Case Major210Case HWE"NO, P=0.01"
Control Minor111Control Major181Control HWE:"YES, P=0.7"
Case AA:3Case AB64Case BB73
Control AA20Control AB71Control BB:55
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 223
KARG ID:ASSO0223PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers701492Marker InformationC>TOriginal Report:negative
Ethnic:AsianCase Sample Size136Control Sample Size141
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:80Case Major192Case HWE"NO, P=0.017"
Control Minor91Control Major191Control HWE:"YES, P=0.096"
Case AA:6Case AB68Case BB62
Control AA19Control AB53Control BB:69
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 224
KARG ID:ASSO0224PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers769390Marker InformationA>COriginal Report:negative
Ethnic:AsianCase Sample Size140Control Sample Size144
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:81Case Major199Case HWE"NO, P=0.019"
Control Minor93Control Major195Control HWE:"YES, P=0.129"
Case AA:6Case AB69Case BB65
Control AA19Control AB55Control BB:70
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 225
KARG ID:ASSO0225PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers769393Marker InformationG>AOriginal Report:negative
Ethnic:AsianCase Sample Size137Control Sample Size141
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:58Case Major216Case HWE"YES, P=0.274"
Control Minor72Control Major210Control HWE:"YES, P=0.092"
Case AA:4Case AB50Case BB83
Control AA13Control AB46Control BB:82
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 226
KARG ID:ASSO0226PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers769395Marker InformationT>COriginal Report:negative
Ethnic:AsianCase Sample Size135Control Sample Size143
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:93Case Major177Case HWE"YES, P=0.126"
Control Minor104Control Major182Control HWE:"YES, P=0.264"
Case AA:12Case AB69Case BB54
Control AA22Control AB60Control BB:61
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 227
KARG ID:ASSO0227PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers769404Marker InformationT>COriginal Report:negative
Ethnic:AsianCase Sample Size137Control Sample Size144
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:134Case Major140Case HWE"NO, P=0.021"
Control Minor122Control Major166Control HWE:"YES, P=0.774"
Case AA:26Case AB82Case BB29
Control AA25Control AB72Control BB:47
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 228
KARG ID:ASSO0228PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD1Marker Namers769407Marker InformationG>COriginal Report:negative
Ethnic:AsianCase Sample Size137Control Sample Size145
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:80Case Major194Case HWE"YES, P=0.053"
Control Minor92Control Major198Control HWE:"YES, P=0.091"
Case AA:7Case AB66Case BB64
Control AA19Control AB54Control BB:72
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 229
KARG ID:ASSO0229PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD2Marker Namers1556234Marker InformationG>COriginal Report:negative
Ethnic:AsianCase Sample Size126Control Sample Size141
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:18Case Major254Case HWE"YES, P=0.409"
Control Minor24Control Major258Control HWE:"YES, P=0.29"
Case AA:0Case AB18Case BB118
Control AA2Control AB20Control BB:119
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 230
KARG ID:ASSO0230PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD2Marker Namers2236418Marker InformationA>GOriginal Report:negative
Ethnic:AsianCase Sample Size132Control Sample Size139
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:70Case Major194Case HWE"YES, P=0.9"
Control Minor64Control Major214Control HWE:"YES, P=0.434"
Case AA:9Case AB52Case BB71
Control AA9Control AB46Control BB:84
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 231
KARG ID:ASSO0231PubMed ID17067345Year2006Author Name:Loh el-W
Title:Glutamate decarboxylase genes and alcoholism in Han Taiwanese men
Method:"high throughput, 384-microtiter plate, MassARRAY? System, SEQUENOM"Study Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GAD2Marker Namers2839670Marker InformationC>AOriginal Report:negative
Ethnic:AsianCase Sample Size133Control Sample Size135
Case Age:39(22-69)Case Male%100%Control Age57.5(41-84)Control Male%:100%
Case Minor:74Case Major192Case HWE"YES, P=0.899"
Control Minor62Control Major208Control HWE:"YES, P=0.668"
Case AA:10Case AB54Case BB69
Control AA8Control AB46Control BB:81
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 232
KARG ID:ASSO0232PubMed ID17083333Year2007Author Name:Belfer I
Title:Alcoholism is associated with GALR3 but not two other galanin receptor genes
Method:TaqMan GenotypeStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol dependence
Gene Name:GALR3Marker Namers3091367Marker InformationG>COriginal Report:positive
Ethnic:CaucasianCase Sample Size263Control Sample Size251
Case Age:see Belfer et al. 2006; Enoch et al. 2006a; Lappalainen et al.Case Male%NAControl AgeNAControl Male%:NA
Case Minor:110.46Case Major410.28Case HWEyes
Control Minor133.03Control Major368.97Control HWE:yes
Case AA:13.15Case AB84.16Case BB163.06
Control AA10.04Control AB112.95Control BB:128.01
Curator:PWZClinical InformationDSM-III-R?
Allelic Contrast Test 233
KARG ID:ASSO0233PubMed ID15729709Year2005Author Name:Hashimoto T
Title:A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population.
Method:RFLPStudy Designcase-controlAddictive DrugMethamphetamine abuserBehavior:NA
Gene Name:Glutathione S-Transferase P1Marker Namers947894Marker InformationNAOriginal Report:positive
Ethnic:japaneseCase Sample Size189Control Sample Size199
Case Age:36.9+/-11.9 (18-69)Case Male%78.80%Control Age37.2+/-10.5 (19-73)Control Male%:78.90%
Case Minor:(13.0%Case Major87%Case HWENA
Control Minor8%Control Major92%Control HWE:NA
Case AA:2.10%Case AB(21.7%Case BB(76.2%
Control AA0Control AB(16.1%Control BB:83.90%
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 234
KARG ID:ASSO0234PubMed ID17621168Year2007Author Name:Guindalini C
Title:Association analysis of GRK3 gene promoter variants in cocaine abuse
Method:K-BiosciencesStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine abuse
Gene Name:GRK3Marker Namers558934Marker InformationNAOriginal Report:negative
Ethnic:"Sao Paulo, Brazil"Case Sample Size711Control Sample Size862
Case Age:26.7(SD=7.23)Case Male%95.80%Control Age31.65(SD=9.89)Control Male%:68.30%
Case Minor:432Case Major968Case HWEYES
Control Minor500Control Major1184Control HWE:YES
Case AA:73Case AB286Case BB341
Control AA78Control AB344Control BB:420
Curator:CYLClinical InformationICD10 diagnosis of cocaine dependence
Allelic Contrast Test 235
KARG ID:ASSO0235PubMed ID17621168Year2007Author Name:Guindalini C
Title:Association analysis of GRK3 gene promoter variants in cocaine abuse
Method:K-BiosciencesStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine abuse
Gene Name:GRK3Marker Namers5761116Marker InformationNAOriginal Report:negative
Ethnic:"Sao Paulo, Brazil"Case Sample Size711Control Sample Size862
Case Age:26.7(SD=7.23)Case Male%95.80%Control Age31.65(SD=9.89)Control Male%:68.30%
Case Minor:177Case Major1195Case HWEYES
Control Minor237Control Major1409Control HWE:YES
Case AA:9Case AB159Case BB518
Control AA18Control AB201Control BB:604
Curator:CYLClinical InformationICD10 diagnosis of cocaine dependence
Allelic Contrast Test 236
KARG ID:ASSO0236PubMed ID17621168Year2007Author Name:Guindalini C
Title:Association analysis of GRK3 gene promoter variants in cocaine abuse
Method:K-BiosciencesStudy Designcase-controlAddictive DrugcocaineBehavior:cocaine abuse
Gene Name:GRK3Marker Namers576895Marker InformationNAOriginal Report:negative
Ethnic:"Sao Paulo, Brazil"Case Sample Size711Control Sample Size862
Case Age:26.7(SD=7.23)Case Male%95.80%Control Age31.65(SD=9.89)Control Male%:68.30%
Case Minor:555Case Major855Case HWEYES
Control Minor660Control Major1024Control HWE:YES
Case AA:111Case AB333Case BB261
Control AA138Control AB384Control BB:320
Curator:CYLClinical InformationICD10 diagnosis of cocaine dependence
Allelic Contrast Test 237
KARG ID:ASSO0237PubMed ID15770103YearNAAuthor Name:Oroszi G
Title:"Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is"
Method:(Taq-ManStudy Designcase-controlAddictive DrugAlcoholicsBehavior:NA
Gene Name:Histamine N-methyltransferase (HNMT)Marker NameNAMarker InformationThr105Ile.T/COriginal Report:"positive,p=0.015"
Ethnic:Finnish CaucasiansCase Sample Size218Control Sample Size313
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:0.12Case Major0.88Case HWENA
Control Minor0.17Control Major0.83Control HWE:NA
Case AA:0.02Case AB0.2Case BB0.78)
Control AA(0.02Control AB(0.30Control BB:(0.68
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 238
KARG ID:ASSO0238PubMed ID15770103YearNAAuthor Name:Oroszi G
Title:"Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is"
Method:(Taq-ManStudy Designcase-controlAddictive DrugAlcoholicsBehavior:NA
Gene Name:Histamine N-methyltransferase (HNMT)Marker NameNAMarker InformationThr105IleOriginal Report:"positive,p=0,023"
Ethnic:Plains American IndiansCase Sample Size186Control Sample Size140
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:0.03Case Major0.97Case HWENA
Control Minor0.08Control Major0.92Control HWE:NA
Case AA:0Case AB0.07Case BB(0.93
Control AA0Control AB0.15)Control BB:0.85
Curator:PWZClinical InformationDSM-III-R
Allelic Contrast Test 239
KARG ID:ASSO0239PubMed ID16950574Year2007Author Name:Reuter M
Title:"Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians"
Method:TaqManStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol abuser
Gene Name:HNMTMarker Namers35953316Marker Information"Thr105Ile, Thr>Ile"Original Report:negative
Ethnic:German CaucasianCase Sample Size366Control Sample Size200
Case Age:"44.74, S.D.?=?9.67"Case Male%85.70%Control Age"41.64, S.D.?=?14.91"Control Male%:73.60%
Case Minor:83Case Major649Case HWE"YES, 0.624"
Control Minor41Control Major359Control HWE:"YES, 0.624"
Case AA:2Case AB79Case BB285
Control AA3Control AB35Control BB:162
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 240
KARG ID:ASSO0240PubMed ID16950574Year2007Author Name:Reuter M
Title:"Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians"
Method:TaqManStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol abuser
Gene Name:HNMTMarker Namers35953316Marker Information"Thr105Ile, Thr>Ile"Original Report:negative
Ethnic:FinnsCase Sample Size218Control Sample Size313
Case Age:"44.74, S.D.?=?9.67"Case Male%85.70%Control Age"41.64, S.D.?=?14.91"Control Male%:73.60%
Case Minor:51Case Major385Case HWE"YES, 0.624"
Control Minor107Control Major519Control HWE:"YES, 0.624"
Case AA:4Case AB43Case BB171
Control AA6Control AB95Control BB:212
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 241
KARG ID:ASSO0241PubMed ID16950574Year2007Author Name:Reuter M
Title:"Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians"
Method:TaqManStudy Designcase-controlAddictive DrugalcoholBehavior:alcohol abuser
Gene Name:HNMTMarker Namers35953316Marker Information"Thr105Ile, Thr>Ile"Original Report:negative
Ethnic:Plains IndiansCase Sample Size186Control Sample Size140
Case Age:"44.74, S.D.?=?9.67"Case Male%85.70%Control Age"41.64, S.D.?=?14.91"Control Male%:73.60%
Case Minor:13Case Major359Case HWE"YES, 0.624"
Control Minor21Control Major259Control HWE:"YES, 0.624"
Case AA:0Case AB13Case BB173
Control AA0Control AB21Control BB:119
Curator:CYLClinical Information"F10.25, ICD10"
Allelic Contrast Test 242
KARG ID:ASSO0242PubMed ID16314758Year2006Author Name:Dahl JP
Title:Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
Method:NAStudy Designcase-controlAddictive Drugcocaine dependence Behavior:NA
Gene Name:Homer1Marker Namers6871510Marker InformationNAOriginal Report:"positive,P=0.029"
Ethnic:African American Case Sample Size170Control Sample Size90
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:NACase MajorNACase HWEgenotype level
Control MinorNAControl MajorNAControl HWE:NA
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:PWZClinical InformationNA
Allelic Contrast Test 243
KARG ID:ASSO0243PubMed ID16344719Year2006Author Name:Proudnikov D
Title:Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes
Method:TaqManStudy Designcase-controlAddictive DrugopioidsBehavior:heroin addiction
Gene Name:HTR1BMarker NameNAMarker Information"T>G, -261"Original Report:negative
Ethnic:African AmericanCase Sample Size53Control Sample Size41
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:21Case Major85Case HWENA
Control Minor24Control Major58Control HWE:OK
Case AA:NACase ABNACase BBNA
Control AANAControl ABNAControl BB:NA
Curator:CYLClinical InformationDSM-IV
Allelic Contrast Test 244
KARG ID:ASSO0244PubMed ID16344719Year2006Author Name:Proudnikov D
Title:Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes
Method:TaqManStudy Designcase-controlAddictive DrugopioidsBehavior:heroin addiction
Gene Name:HTR1BMarker NameNAMarker Information"A>T, -161"Original Report:negative
Ethnic:African AmericanCase Sample Size53Control Sample Size41
Case Age:NACase Male%NAControl AgeNAControl Male%:NA
Case Minor:9Case Major97Case HWENA
Control Minor6Control Major76Control HWE:OK
Case AA:NACase ABNACase BBNA
Control AA