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KARG >> Addiction Related Pathways (Homo Sapiens)
Several addiction-enriched KEGG pathways including both metabolic pathways and signalling pathways have been identified by KOBAS (KEGG Orthology-Based Annotation System), an automatic annotation system to annotate a set of nucleotide or protein sequences with KEGG Orthology terms based on BLAST similarity search against KEGG GENES(Mao et al, Bioinformatics, 2005).

Common Molecular Pathways for Drug Addiction

Addictive Drugs

COCAINE

ALCOHOL

OPIOIDS

NICOTINE

Neuroactive ligand-receptor interaction

P-Values

5.39E-05**

3.24E-02*

2.68E-03**

7.79E-03**

Q-Values

1.8E-04**

0.05*

0.01*

0.04*

Long-term potentiation

P-Values

3.21E-08**

8.28E-03**

1.05E-02*

8.84E-03**

Q-Values

2.8E-07**

0.03*

0.03*

0.04*

GnRH signaling pathway

P-Values

2.84E-05**

3.93E-04**

4.67E-03**

1.72E-02*

Q-Values

1.2E-04**

3.6E-03**

0.02*

0.05*

MAPK signaling pathway

P-Values

1.28E-04**

2.97E-04**

7.34E-05**

1.10E-02*

Q-Values

3.7E-04**

3.6E-03**

5.2E-04**

0.04*

Gap junctions

P-Values

1.93E-08**

3.11E-03**

3.30E-03**

5.85E-03**

Q-Values

2.8E-07**

0.01**

0.01**

0.03*

KEGG Pathways for Drug Addiction (Using 396 gene sets)

 

Long-term depression

2.1E-07**

1.1E-05**

Gap junction

1.5E-07**

1.1E-05**

Long-term potentiation

3.5E-06**

7.2E-05**

Neuroactive ligand-receptor interaction

2.1E-06**

7.2E-05**

MAPK signaling pathway

3.1E-06**

7.2E-05**

GnRH signaling pathway

8.5E-06**

1.5E-04**

Calcium signaling pathway

4.8E-04**

7.0E-03**

Colorectal cancer

6.5E-04**

8.3E-03**

Pores ion channels

2.1E-03**

0.02*

VEGF signaling pathway

3.2E-03**

0.03*

Glycolysis /Gluconeogenesis

3.8E-03**

0.03*

Protein folding and associated processing

3.8E-03**

0.03*

Focal adhesion

4.4E-03**

0.03*

Insulin signaling pathway

4.9E-03**

0.03*

Parkinson's disease

6.3E-03**

0.04*

Fc epsilon RI signaling pathway

6.9E-03**

0.04*

Type II diabetes mellitus

7.7E-03**

0.05*

Progesterone-mediated oocyte maturation

9.1E-03**

0.05*

KEGG Pathways for Drug Addiction (Using 1500 gene sets)

Long-term potentiation 3.05E-08** 4.44E-06**
Gap junction 5.13E-08** 4.44E-06**
Long-term depression 6.75E-06** 3.89E-04**
Neuroactive ligand-receptor interaction 2.04E-05** 6.67E-04**
MAPK signaling pathway 2.66E-05** 6.67E-04**
GnRH signaling pathway 2.70E-05** 6.67E-04**
Calcium signaling pathway 1.58E-05** 6.67E-04**
Amyotrophic lateral sclerosis (ALS) 3.86E-05** 8.35E-04**
Colorectal cancer 9.18E-04** 1.59E-02*
Progesterone-mediated oocyte maturation 8.29E-04** 1.59E-02*
Type I diabetes mellitus 1.16E-03** 1.82E-02*
Oxidative phosphorylation 1.34E-03** 1.93E-02*
Stilbene, coumarine and lignin biosynthesis 1.63E-03** 2.13E-02*
Pores ion channels 1.72E-03** 2.13E-02*
Type II diabetes mellitus 2.03E-03** 2.34E-02*
Focal adhesion 2.76E-03** 2.99E-02*
Parkinson's disease 3.49E-03** 3.55E-02*
Glutamate metabolism 5.36E-03** 5.15E-02
 

In these tables, ‘*’ indicates a P-Value/Q-Value less than 0.05, ‘**’ indicates a P-Value/Q-Value less than 0.01.


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