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KARG (Knowledgebase for Addiction Related Genes) >> CY's HomePage
This is the HomePage of Chuan-Yun ('CY') Li.
 Chuan-Yun Li, Ph.D.

 1. Core of Bioinformatics and Systems Biology, the Institute of Molecular Medicine (IMM)

     Peking University, Beijing, P. R. China, 100871

 2. Center for Bioinformatics (CBI), College of Life Science

     Peking University, Beijing, P. R. China, 100871

 Contact:

 Email: licy AT mail.cbi.pku.edu.cn

 Fax: 8610-62751861

 

     
  Research Interests
  • Molecular networks and molecular genetics that underlie addiction;

  • Data integration and systems biology of complex diseases;

  • Personalized medicine;

  • Molecular evolution;

  • Functional and comparative genomics;

  • Protein structure variations and disease;

  • Development of bioinformatic databases and web service;

  Publications
    
1. Chuan-Yun Li, Yong Zhang, Zhanbo Wang, Yan Zhang, Chunmei Cao, Xiao-Mo Li, Ping-Wu Zhang, Shu-Juan Lu, Quan Yu, Xiaofeng Zheng, Quan Du, Qing-Rong Liu and Liping Wei. A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions. PLoS Computational Biology, 2010

2. Chuan-Yun Li, Xizeng Mao & Liping Wei. Genes and (Common) Pathways Underlying Drug Addiction. PLoS Computational Biology, 2008, 4(1): e2. doi:10.1371/journal.pcbi.0040002

3. Chuan-Yun Li, Qingrong Liu, Ping-Wu Zhang, Xiao-Mo Li, Liping Wei, George R Uhl. OKCAM: An Ontology-based, Human-centered Knowledgebase for Cell Adhesion Molecules; Nucleic Acid Research, 2008

4. Chuan-Yun Li, Zhi-Qiang Ye, Quan Yu, Ying Sun, Quanyuan He, Xiao-Mo Li, Wuxue Zhang, Jingchu Luo, Xiaocheng Gu, Xiaofeng Zheng & Liping Wei. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Research 2007; 17: 357-362.

5. Catherine Johnson, Tomas Drgon, Qing-Rong Liu, Ping-Wu Zhang, Donna Walther, Chuan-Yun Li, James Anthony, Yulan Ding, William Eaton and George R Uhl, Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples; BMC Medical Genetics, 2008

6. George R Uhl, Tomas Drgon, Catherine Johnson, Oluwatosin O. Fatusin, Qing-Rong Liu, Carlo Contoreggi, Chuan-Yun Li, Kari Buck, John Crabbe. "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice, Biochemical Pharmacology 2007;

7. George R Uhl, Tomas Drgon, Catherine Johnson, Chuan-Yun Li, Judith Hess, Daniel Naimen, Qing-Rong Liu. Molecular genetics of addiction and related heritable phenotypes: genome wide association approaches identify “connectivity constellation” and drug target genes with pleiotropic effects. Ann N Y Acad Sci, 2008;

8. Saccone SF, Bierut LJ, Chesler EJ, Kalivas PW, Lerman C, Saccone NL, Uhl GR, Li CY, Philip VM, Edenberg HJ, Sherry ST, Feolo M, Moyzis RK, Rutter JL. Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS One. 2009;4(4):e5225.

9. Uhl GR, Drgon T, Li CY, Johnson C, Liu QR. Smoking and smoking cessation in disadvantaged women: Assessing genetic contributions. Drug Alcohol Depend. 2009 May 11.

10. Liu QR, Pan CH, Hishimoto A, Li CY, Xi ZX, Llorente-Berzal A, Viveros MP, Ishiguro H, Arinami T, Onaivi ES, Uhl GR. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. 2009 Jul;8(5):519-30.
 

11. HUANG Mo-Li, SUN Dao-Chun, Lou Ya-Xin, YIN Yan-Bin, LI Chuan-Yun, ZHANG Yong, GAO Ge, WANG Sheng-Qi, BO Xiao-Chen, WEI Li-Ping, LI Song-Gang. Analysis and Preparation of Oligonucletide Microarray of Apoptosis-related Genes. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 2008:35(12) .
 

  Patents  

       1. 魏丽萍,李川昀,叶志强等;一种预测达菲类药物用药安全性的方法;申请日期:2006年3月28日 (Date applied: 3-28-2006)。授权日期:2008年3月26日。专利号:ZL 200610011569.3


       2. Liping Wei, Chuan-Yun Li, ZhiQiang Ye, QuanYuan He, Quan Yu, WuXue Zhang, Ying Sun, JingChu Luo, XiaoCheng Gu, XiaoFeng Zheng. METHOD OF PREDICTING ADMINISTRATING SAFETY OF OSELTAMIVIR PHOSPHATE MEDICINE
;PCT Patent Application Number:PCT/CN2007/000716,PCT Patent number:WO/2007/115467
 

  Center for Bioinformatics(CBI), Peking University. Any Comments and suggestions to : KARG GROUP