Quick Search By Entrez Gene ID (example:9252) :   KARG >> Publications Linking Genes & Chromosome Regions to Addiction Our list of publications included recent review papers on addiction selected from results of PUBMED query '(addiction OR "drug abuse") AND review' as well as research papers selected from PUBMED query '(addiction OR "drug abuse") AND (gene OR microarray OR proteomics OR QTL OR "population association" OR "genetic linkage")'. We probably cannot claim that our collection represents "all" of the publications with addiction genes, but we are confident that our collection is by far the most comprehensive to date. To cite this work, please refer to: Li CY, Mao X, Wei L (2008) Genes and (common) pathways underlying drug addiction. PLoS Comput Biol 4(1): e2. doi:10.1371/journal.pcbi.0040002 PUBMED ID Title First Author Pub Time Journal 107447 Evidence for the absence of a mutagenic effect of methadone in germ cells of Drosophila melanogaster. Zimmering S 1979 Feb Mutat Res 158518 Genetic screening of compounds used in drug abuse treatment. I. Naltrexone hydrochloride. Brusick D 1978 Drug Chem Toxicol 510177 The genetic interface of addiction. Ginsburg BE 1979 Jan-Mar Drug Alcohol Depend 558580 A bioanthropological overview of addiction. Jonas DF 1977 Spring Perspect Biol Med 1096556 Genetic determinants of alcohol addiction. Goodwin DW 1975 Adv Exp Med Biol 1328660 The neurotoxin 1-methyl-4-phenylpyridinium: a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties. Marini AM 1992 Oct 21 J Natl Cancer Inst 1337927 Organization and expression of the gene encoding chick kainate binding protein, a member of the glutamate receptor family. Gregor P 1992 Dec Brain Res Mol Brain Res 1355337 Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers. Smith SS 1992 Sep Arch Gen Psychiatry 1363329 Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations. Uhl GR 1992 Dec Brain Res Mol Brain Res 1372443 Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice. Donovan DM 1992 Mar 15 Proc Natl Acad Sci U S A 1381123 Neurotransmitter transporters (plus): a promising new gene family. Uhl GR 1992 Jul Trends Neurosci 1471756 Low platelet gamma-aminobutyrate aminotransferase and monoamine oxidase activities in chronic alcoholic patients. Sherif F 1992 Dec Alcohol Clin Exp Res 1476417 [Haptoglobin polymorphism--not only a genetic marker] Lange V 1992 Dec Anthropol Anz 1478653 Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Vandenbergh DJ 1992 Dec Genomics 1491719 Regulation of gene expression by dopamine: implications in drug addiction. Conneely OM 1992 NIDA Res Monogr 1515577 Expression of a single dopamine transporter cDNA can confer two cocaine binding sites. Boja JW 1992 Mar Neuroreport 1531356 Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. Guitart X 1992 Mar J Neurochem 1630603 Cholecystokinin (CCK)-like material and CCK mRNA levels in the rat brain and spinal cord after acute or repeated morphine treatment. Pohl M 1992 Mar Neuropeptides 1631058 Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Hope B 1992 Jul 1 Proc Natl Acad Sci U S A 1650871 [Molecular neurobiological research in the fight against drug abuse] Terenius L 1991 Jul 24 Lakartidningen 1674558 [Genetic factors and smoking habits] Yamaguchi E 1991 Feb Nihon Kyobu Shikkan Gakkai Zasshi 1676593 Human T-cell leukemia virus infection in non-intravenous drug using HIV seropositive men in Los Angeles. Aboulafia DM 1991 Mar AIDS Res Hum Retroviruses 1682022 Expression of the immediate early gene c-fos in basal ganglia: induction by dopaminergic drugs. Robertson HA 1991 Aug Can J Neurol Sci 1725703 The molecular biology of addictive drugs. Mackler SA 1991 Spring Mol Neurobiol 1758988 Epidemiological perspectives on children of alcoholics. Dinwiddie SH 1991 Recent Dev Alcohol 1782144 Hepatitis C in deceased drug addicts. Trubner K 1991 Int J Legal Med 1832466 The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. Comings DE 1991 Oct 2 JAMA 1875992 Synaptic regulation of the enkephalin gene and transcription factors in vivo: possible roles in drug abuse. Uhl GR 1990 NIDA Res Monogr 1903698 Differential responsiveness of the pituitary-thyroid axis to thyrotropin-releasing hormone in mouse lines selected to differ in central nervous system sensitivity to ethanol. Erickson JD 1991 Jun Endocrinology 1941526 Diagnosis and differentiation of HTLV-I and HTLV-II infection by enzyme immunoassays using synthetic peptides. Viscidi RP 1991 J Acquir Immune Defic Syndr 1975640 Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Sunahara RK 1990 Sep 6 Nature 2063922 Clinical and genetic relationships between autism-pervasive developmental disorder and Tourette syndrome: a study of 19 cases. Comings DE 1991 May 1 Am J Med Genet 2065120 Use of recombinant inbred strains to assess vulnerability to drug abuse at the genetic level. Phillips TJ 1991 J Addict Dis 2118661 Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Graybiel AM 1990 Sep Proc Natl Acad Sci U S A 2365666 A controlled family history study of Tourette's syndrome, II: Alcoholism, drug abuse, and obesity. Comings DE 1990 Jul J Clin Psychiatry 2596529 Hypothesis: homozygosity in Tourette syndrome. Comings DE 1989 Nov Am J Med Genet 2840804 HIV receptor in brain and deduced peptides that block viral infectivity. Pert CB 1988 Adv Biochem Psychopharmacol 2974511 Cloning and expression of a rat D2 dopamine receptor cDNA. Bunzow JR 1988 Dec 22-29 Nature 3144275 Morphine activation of c-fos expression in rat brain. Chang SL 1988 Dec 15 Biochem Biophys Res Commun 3163359 Prognostic significance of adenosine deaminase determinations in subjects with the lymphoadenopathy syndrome. Casoli C 1988 Apr J Med Virol 3167377 The current age of youthful melancholia. Evidence for increase in depression among adolescents and young adults. Klerman GL 1988 Jan Br J Psychiatry 3417233 Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication. Chen PJ 1988 Sep-Oct Hepatology 3475243 [Acquired immunologic deficiency syndrome (AIDS). I. Biologic principles] Negele J 1987 Jun Fortschr Neurol Psychiatr 6455283 Genetic screening of compounds used in drug abuse treatment. II. Methadone. Brusick D 1981 Drug Chem Toxicol 7494469 Programmed cell death in bacteria: proteic plasmid stabilization systems. Jensen RB 1995 Jul Mol Microbiol 7494470 Comparison of ccd of F, parDE of RP4, and parD of R1 using a novel conditional replication control system of plasmid R1. Jensen RB 1995 Jul Mol Microbiol 7498314 Transgenic superoxide dismutase mice differ in opioid-induced analgesia. Elmer GI 1995 Sep 5 Eur J Pharmacol 7506420 Cellular adaptation to opiates alters ion-channel mRNA levels. Mackler SA 1994 Jan 4 Proc Natl Acad Sci U S A 7550364 Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Blum K 1995 Jun Pharmacogenetics 7573171 DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Adamson MD 1995 Jun 19 Am J Med Genet 7598467 Hepatitis C: an overview. Bhandari BN 1995 Annu Rev Med 7647164 Dopamine D2 receptor gene (DRD2) haplotypes and the defense style questionnaire in substance abuse, Tourette syndrome, and controls. Comings DE 1995 Jun 1 Biol Psychiatry 7647833 Tourette syndrome: a hereditary neuropsychiatric spectrum disorder. Comings DE 1994 Dec Ann Clin Psychiatry 7681236 Substance abuse vulnerability and D2 receptor genes. Uhl G 1993 Mar Trends Neurosci 7694454 Expression of the beta 1 chain (CD29) of integrins and CD45 in alcoholic liver disease. The VA Cooperative Study Group No. 275. Chedid A 1993 Nov Am J Gastroenterol 7724703 Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice. Miner LL 1995 Jan Psychopharmacology (Berl) 7752808 Chromosomal localization of opioid peptide and receptor genes in the mouse. Giros B 1995 Life Sci 7755894 NMDA and D1 receptors mediate induction of c-fos and junB genes in striatum following morphine administration: implications for studies of memory. Sharp FR 1995 Jan 23 Behav Brain Res 7756606 Decrease in CRE binding activity by chronic morphine administration in mouse brain. Ikemoto M 1995 Jan 26 Neuroreport 7774940 Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3. Patel A 1995 Jan 1 Genomics 7774949 Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD. Gregor P 1995 Jan 1 Genomics 7802105 Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders. Persico AM 1995 Jan Am J Psychiatry 7859110 Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus. Nestler EJ 1994 Brain Res Bull 7859833 Molecular subtypes of env sequences around V3 region of human immunodeficiency virus type 1 in Taiwan. Chang KS 1994 Jun Eur J Epidemiol 7881434 Dinucleotide repeat polymorphism in the human taurine transporter gene (TAUT). Gregor P 1994 Dec Hum Mol Genet 7891851 The dopamine transporter and dopamine D2 receptor messenger RNAs are differentially expressed in limbic- and motor-related subpopulations of human mesencephalic neurons. Hurd YL 1994 Nov Neuroscience 7913352 Association strategies in substance abuse. Uhl GR 1994 EXS 7932176 Genetic analysis of sensitization and tolerance to cocaine. Tolliver BK 1994 Sep J Pharmacol Exp Ther 7959416 [Molecular diversity and properties of brain nicotinic acetylcholine receptor] Nakayama H 1994 Sep Nippon Yakurigaku Zasshi 7959697 Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Gregor P 1994 Nov Hum Genet 7971989 Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Widnell KL 1994 Nov 8 Proc Natl Acad Sci U S A 8015373 Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration. Cerruti C 1994 Mar Brain Res Mol Brain Res 8026588 cDNA cloning of an orphan opiate receptor gene family member and its splice variant. Wang JB 1994 Jul 4 FEBS Lett 8033754 The dopamine D2 receptor gene: a genetic risk factor in substance abuse. Comings DE 1994 Feb Drug Alcohol Depend 8057783 'Choline/orphan V8-2-1/creatine transporter' mRNA is expressed in nervous, renal and gastrointestinal systems. Gonzalez AM 1994 May Brain Res Mol Brain Res 8071542 Polymerase chain reaction analysis of hepatitis B virus DNA in formalin-fixed, paraffin-embedded liver biopsies from alcoholics using a simplified and standardized amplification protocol. von Weizsacker F 1994 May J Hepatol 8075641 Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Berrettini WH 1994 May Nat Genet 8075641 Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Berrettini WH 1994 May Nat Genet 8078918 Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Liu J 1994 Aug 30 Proc Natl Acad Sci U S A 8082550 Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. I. Drug abuse. Comings DE 1994 Mar Drug Alcohol Depend 8082551 Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. II. Alcohol abuse. Comings DE 1994 Mar Drug Alcohol Depend 8096458 Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant: relevance for alcoholism and drug abuse. Persico AM 1993 Feb Drug Alcohol Depend 8104042 Comorbid psychopathy is not associated with increased D2 dopamine receptor TaqI A or B gene marker frequencies in incarcerated substance abusers. Smith SS 1993 Jun 1-15 Biol Psychiatry 8216280 Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism. George SR 1993 Oct 15 Biochem Biophys Res Commun 8234282 mu opiate receptor: cDNA cloning and expression. Wang JB 1993 Nov 1 Proc Natl Acad Sci U S A 8255186 Brain transcription factor expression: effects of acute and chronic amphetamine and injection stress. Persico AM 1993 Oct Brain Res Mol Brain Res 8260617 Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. Gregor P 1993 Sep 30 Neuroreport 8274284 Drug addiction: a model for the molecular basis of neural plasticity. Nestler EJ 1993 Dec Neuron 8309808 Differential diagnosis and psychopharmacology of dual disorders. Decker KP 1993 Dec Psychiatr Clin North Am 8328456 Anticipation in bipolar affective disorder. McInnis MG 1993 Aug Am J Hum Genet 8341369 Immediate early gene activation and long-term changes in neural function: a possible role in addiction? Robertson HA 1993 NIDA Res Monogr 8341370 Regulation of neural gene expression in opiate and cocaine addiction. Nestler EJ 1993 NIDA Res Monogr 8381898 Fos family member changes in nucleus caudalis neurons after primary afferent stimulation: enhancement of fos B and c-fos. Walther D 1993 Jan Brain Res Mol Brain Res 8385277 Second messenger and protein phosphorylation mechanisms underlying opiate addiction: studies in the rat locus coeruleus. Guitart X 1993 Jan Neurochem Res 8385579 Cellular responses to chronic treatment with drugs of abuse. Nestler EJ 1993 Crit Rev Neurobiol 8399824 Dopamine transporter gene polymorphisms are not associated with polysubstance abuse. Persico AM 1993 Aug 15 Biol Psychiatry 8411153 Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. Lehnherr H 1993 Oct 5 J Mol Biol 8413963 Genomic imprinting and anticipation in idiopathic torsion dystonia. LaBuda MC 1993 Oct Neurology 8445366 Molecular characterization of two isolates of human T cell leukaemia virus type II from Italian drug abusers and comparison of genome structure with other isolates. Zella D 1993 Mar J Gen Virol 8464923 Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans. Gregor P 1993 Apr 1 Proc Natl Acad Sci U S A 8477052 Ibogaine induces glial activation in parasagittal zones of the cerebellum. O'Hearn E 1993 Mar Neuroreport 8488955 DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Goldman D 1993 Apr Alcohol Clin Exp Res 8512534 Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice. Belknap JK 1993 Mar Behav Genet 8582088 Opioids and pain. Kanjhan R 1995 Jun-Jul Clin Exp Pharmacol Physiol 8602733 Transgenic mice: preproenkephalin and the mu opiate receptor. Donovan DM 1996 Mar 22 Ann N Y Acad Sci 8630246 Addiction to cocaine and amphetamine. Hyman SE 1996 May Neuron 8640219 Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice. Melo JA 1996 Jun Nat Genet 8645779 The D2 dopamine receptor gene, addiction, and personality: clinical correlates in cocaine abusers. Compton PA 1996 Feb 15 Biol Psychiatry 8650219 An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Aizenman E 1996 Jun 11 Proc Natl Acad Sci U S A 8661009 The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Primo-Parmo SL 1996 May 1 Genomics 8674469 [The dopamine transporter: characterization and physiopathologic implications] Thibaut F 1995 Nov-Dec Encephale 8698115 Experimental liver fibrosis induced in rats receiving high doses of alcohol and alternating between regular and vitamin-depleted diets. Hirano H 1996 Jul 15 Experientia 8702525 Autoregulation of the plasmid addiction operon of bacteriophage P1. Magnuson R 1996 Aug 2 J Biol Chem 8747144 Retained cocaine conditioned place preference in D1 receptor deficient mice. Miner LL 1995 Nov 27 Neuroreport 8750825 Increased expression of synapsin I mRNA in defined areas of the rat central nervous system following chronic morphine treatment. Matus-Leibovitch N 1995 Dec 28 Brain Res Mol Brain Res 8750881 Prenatal morphine exposure differentially alters expression of opioid peptides in striatum of newborns. Tempel A 1995 Nov Brain Res Mol Brain Res 8784854 Genetic factors in drug abuse and dependence. Comings DE 1996 NIDA Res Monogr 8794897 Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Alvaro JD 1996 Sep Mol Pharmacol 8807661 A study of the dopamine D2 receptor gene in pathological gambling. Comings DE 1996 Jun Pharmacogenetics 8825889 Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples. Gorwood P 1995 Dec 18 Am J Med Genet 8825897 Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders. Persico AM 1995 Dec 18 Am J Med Genet 8832655 Effects of chronic nicotine treatment on the expression of phospholipase C isozymes and the alpha subunit of Gq/11 protein in the rat brain. Pandey SC 1996 Jul 12 Neurosci Lett 8837980 Reduced dopaminergic function in alcoholics is related to severe dependence. Schmidt LG 1996 Feb 1 Biol Psychiatry 8843485 Individual and combined effects of ethanol and cocaine on intracellular signals and gene expression. Torres G 1996 May Prog Neuropsychopharmacol Biol Psychiatry 8845863 The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking. Comings DE 1996 Feb Pharmacogenetics 8859207 Understanding drug addiction: implications for treatment. Leshner AI 1996 Oct 15 Hosp Pract (Minneap) 8873216 Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Blum K 1996 Aug Pharmacogenetics 8874837 Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication. Comings DE 1996 Sep 1 Biol Psychiatry 8889398 Mating assortment and the liability to substance abuse. Vanyukov MM 1996 Sep Drug Alcohol Depend 8894071 D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. Persico AM 1996 Oct 15 Biol Psychiatry 8907305 Allele-specific PCR for simultaneous amplification of both alleles of a deletion polymorphism in intron 6 of the human dopamine 2 receptor gene (DRD2). Finckh U 1996 DNA Seq 8943583 Cocaine, dopamine and the endogenous opioid system. Kreek MJ 1996 J Addict Dis 8947327 Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Johnson EO 1996 Nov Alcohol Clin Exp Res 8959019 Novel transcription factors are induced by chronic cocaine treatment. Hope BT 1996 Oct 31 Ann N Y Acad Sci 8962158 Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Moratalla R 1996 Dec 10 Proc Natl Acad Sci U S A 8974318 Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Crabbe JC 1994 Alcohol Alcohol Suppl 8987796 Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. Grisel JE 1997 Jan 15 J Neurosci 9023306 Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects. Erwin VG 1997 Feb J Pharmacol Exp Ther 9024952 Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Sander T 1997 Feb 1 Biol Psychiatry 9044501 Transcription factors: potential roles in drug-induced neuroplasticity. Persico AM 1996 Oct-Dec Rev Neurosci 9067644 Immunoregulatory effects of morphine on human lymphocytes. Nair MP 1997 Mar Clin Diagn Lab Immunol 9075653 Distribution of hepatitis C virus genotypes in German patients with chronic hepatitis C: correlation with clinical and virological parameters. Berg T 1997 Mar J Hepatol 9095308 The formation and measurement of DNA neuroadduction in alcoholism. Case report. Steinberg JJ 1997 Mar Am J Forensic Med Pathol 9106242 Cannabinoid receptor gene (CNR1): association with i.v. drug use. Comings DE 1997 Mar Mol Psychiatry 9129716 D2 dopamine receptor polymorphism and brain regional glucose metabolism. Noble EP 1997 Apr 18 Am J Med Genet 9133412 Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. Buck KJ 1997 May 15 J Neurosci 9145787 The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia. Sora I 1997 Apr 18 Eur J Pharmacol 9152990 Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Kotler M 1997 May Mol Psychiatry 9197282 Nicotine regulates mRNA level of tyrosine hydroxylase gene but not that of nicotinic acetylcholine receptor genes in PC12 cells. Ishiguro H 1997 May 30 Neurosci Lett 9221795 rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitization. Wang XB 1997 Aug 1 J Neurosci 9259381 High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Vandenbergh DJ 1997 Jul 25 Am J Med Genet 9294222 FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Hiroi N 1997 Sep 16 Proc Natl Acad Sci U S A 9326303 Amino-terminal analysis of tryptophan hydroxylase: protein kinase phosphorylation occurs at serine-58. Kumer SC 1997 Oct J Neurochem 9328073 Dopaminergic genes and substance abuse. Uhl GR 1998 Adv Pharmacol 9371903 Gene locus FPD1 of the dystonic Mount-Reback type of autosomal-dominant paroxysmal choreoathetosis. Hofele K 1997 Nov Neurology 9380041 The dopamine transporter: a crucial component regulating dopamine transmission. Jaber M 1997 Sep Mov Disord 9384550 Molecular mechanisms of opiate and cocaine addiction. Nestler EJ 1997 Oct Curr Opin Neurobiol 9387858 Murine vesicular monoamine transporter 2: molecular cloning and genomic structure. Takahashi N 1997 Oct 3 Brain Res Mol Brain Res 9394128 Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring. Allan AM 1997 Nov Alcohol Clin Exp Res 9398650 Intronic sequences are involved in neural targeting of human dopamine transporter gene expression. Kouzmenko AP 1997 Nov 26 Biochem Biophys Res Commun 9399693 Genotypic selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse. McClearn GE 1997 Oct-Nov Mol Psychiatry 9426133 The poison-antidote stability system of the broad-host-range Thiobacillus ferrooxidans plasmid pTF-FC2. Smith AS 1997 Dec Mol Microbiol 9427251 Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Wang YM 1997 Dec Neuron 9473720 Subtracted differential display: genes with amphetamine-altered expression patterns include calcineurin. Wang XB 1998 Jan Brain Res Mol Brain Res 9489734 Chronic ethanol treatment decreases [3H]epibatidine and [3H]nicotine binding and differentially regulates mRNA levels of nicotinic acetylcholine receptor subunits expressed in M10 and SH-SY5Y neuroblastoma cells. Gorbounova O 1998 Mar J Neurochem 9491813 Correlation of length of VNTR alleles at the X-linked MAOA gene and phenotypic effect in Tourette syndrome and drug abuse. Gade R 1998 Jan Mol Psychiatry 9498485 Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. Spitz MR 1998 Mar 4 J Natl Cancer Inst 9500675 Genetic analysis of drug addiction: the role of cAMP response element binding protein. Blendy JA 1998 Feb J Mol Med 9548265 Hepatitis C virus genotypes: epidemiological and clinical associations. Benelux Study Group on Treatment of Chronic Hepatitis C. Kleter B 1998 Feb Liver 9560260 The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies. Ditzel HJ 1998 Apr 28 Proc Natl Acad Sci U S A 9583233 An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study. Vanyukov MM 1998 Mar Behav Genet 9600964 Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene. Gaveriaux-Ruff C 1998 May 26 Proc Natl Acad Sci U S A 9603521 Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Rocha BA 1998 May 14 Nature 9603606 Genome-wide search for genes affecting the risk for alcohol dependence. Reich T 1998 May 8 Am J Med Genet 9603607 Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Long JC 1998 May 8 Am J Med Genet 9639280 Differential regulation of the cloned kappa and mu opioid receptors. Tallent M 1998 Aug Neuroscience 9645967 Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain. Manzanares J 1998 Mar 30 Brain Res Mol Brain Res 9655868 Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. Crabbe JC 1998 Jul J Pharmacol Exp Ther 9660170 The human mu opioid receptor gene: 5' regulatory and intronic sequences. Wendel B 1998 Jun J Mol Med 9668659 Cocaine and the AP-1 transcription factor complex. Hope BT 1998 May 30 Ann N Y Acad Sci 9668662 Unraveling dopamine D3 receptor function in response to psychostimulants using a genetic approach. Xu M 1998 May 30 Ann N Y Acad Sci 9675304 Effect of nicotine use and withdrawal on brain preproenkephalin A mRNA. Houdi AA 1998 Jul 20 Brain Res 9677290 The entericidin locus of Escherichia coli and its implications for programmed bacterial cell death. Bishop RE 1998 Jul 24 J Mol Biol 9686001 [Dopamine control of neuroendocrine functions. New findings based on the study of transgenic animals] Jaber M 1997 Ann Endocrinol (Paris) 9689128 Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Bond C 1998 Aug 4 Proc Natl Acad Sci U S A 9691193 Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Drago J 1998 Dev Neurosci 9691338 [Rhabdomyolysis in carnitine palmitoyltransferase II deficiency: developments in pathophysiology, diagnosis and therapy] Imoberdorf R 1998 Jun 20 Schweiz Med Wochenschr 9693390 Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Lesch KP 1998 Aug 1 Biol Psychiatry 9698095 Lack of evidence of kappa2-selective activation of G-proteins: kappa opioid receptor stimulation of [35S] GTPgammaS binding in guinea pig brain. Childers SR 1998 Jul 1 Biochem Pharmacol 9702742 Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. Duaux E 1998 Jul Mol Psychiatry 9713903 Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia. Li T 1998 Jul 27 Schizophr Res 9716929 Relapse to drug-seeking: neural and molecular mechanisms. Self DW 1998 Jun-Jul Drug Alcohol Depend 9726281 Confirmation of quantitative trait loci for alcohol preference in mice. Tarantino LM 1998 Aug Alcohol Clin Exp Res 9754945 No heroin or morphine 6beta-glucuronide analgesia in mu-opioid receptor knockout mice. Kitanaka N 1998 Aug 14 Eur J Pharmacol 9756038 Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Risinger FO 1998 Sep Alcohol Clin Exp Res 9765582 Autoregulation of the pTF-FC2 proteic poison-antidote plasmid addiction system (pas) is essential for plasmid stabilization. Smith AS 1998 Oct J Bacteriol 9767878 [Transmission modes of hepatitis C virus] Karmochkine M 1998 May 16 Presse Med 9768834 Neuroscience of addiction. Koob GF 1998 Sep Neuron 9783838 Transgenic mice in drug dependence research. Pich EM 1998 Aug Ann Med 9789813 Neural substrate of nicotine addiction as defined by functional brain maps of gene expression. Pich EM 1998 Jun-Aug J Physiol Paris 9813289 Effects of long-term exposure to delta9-THC on expression of cannabinoid receptor (CB1) mRNA in different rat brain regions. Zhuang S 1998 Nov 20 Brain Res Mol Brain Res 9829946 Corepression of the P1 addiction operon by Phd and Doc. Magnuson R 1998 Dec J Bacteriol 9852605 Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. Numan S 1998 Dec 15 J Neurosci 9855288 CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats. Navarro M 1998 Oct 26 Neuroreport 9856954 Regulation of cocaine reward by CREB. Carlezon WA Jr 1998 Dec 18 Science 9860116 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice. Engel SR 1998 Nov Psychopharmacology (Berl) 9860994 rexB of bacteriophage lambda is an anti-cell death gene. Engelberg-Kulka H 1998 Dec 22 Proc Natl Acad Sci U S A 9862779 Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. Kreek MJ 1999 Jan J Pharmacol Exp Ther 9866829 [Structure and function of neural plasticity-related gene products] Yamagata K 1998 Aug Nihon Shinkei Seishin Yakurigaku Zasshi 9880575 Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. Demarest K 1999 Jan 15 J Neurosci 9880655 Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Gill K 1998 Dec Mamm Genome 9880656 Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Phillips TJ 1998 Dec Mamm Genome 9880657 A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Peirce JL 1998 Dec Mamm Genome 9880659 Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6J x DBA/2J F2 intercross. Hitzemann R 1998 Dec Mamm Genome 9888857 Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Ledent C 1999 Jan 15 Science 9925040 A genetic association for cigarette smoking behavior. Sabol SZ 1999 Jan Health Psychol 9929680 Apolipoprotein E status is associated with odor identification deficits in nondemented older persons. Murphy C 1998 Nov 30 Ann N Y Acad Sci 9930873 Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Ueki T 1999 Feb Nat Med 10023512 No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. Gelernter J 1999 Feb 1 Biol Psychiatry 10025686 A pharmacologic strategy for the treatment of nicotine addiction. Dewey SL 1999 Jan Synapse 10068276 Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Weinstein IB 1997 Dec Clin Cancer Res 10082218 [D-Ala2, D-Leu5]enkephalin blocks the methamphetamine-induced c-fos mRNA increase in mouse striatum. Hayashi T 1999 Feb 5 Eur J Pharmacol 10101608 [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation] Jaber M 1998 C R Seances Soc Biol Fil 10201639 Chronic treatment with CP-55,940 regulates corticotropin releasing factor and proopiomelanocortin gene expression in the hypothalamus and pituitary gland of the rat. Corchero J 1999 Life Sci 10208445 Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Straub RE 1999 Mar Mol Psychiatry 10213170 Cocaethylene synthesis in Drosophila. 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